Browsing by Author "Odeigha, L.O."

Now showing 1 - 4 of 4
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    Adherence to prescribed drug therapy among adult patients of General Out-Patient Department of a Tertiary Hospital in Nigeria
    (Research Journal of Health Sciences, 2018-06-30) Salaudeen, A.G.; Akande, T.M.; Ologe, M.; Odeigha, L.O.; Medubi, G.F.
    Background: The widespread problems of adherence to medication denied substantial number of patients the maximum benefits of medical treatment, resulting in poor health outcomes, lower quality of life and increased health care costs. The objective of this study was to determine the extent of drug adherence among patients seen in a tertiary hospital in Nigeria. Methods: The study was a descriptive cross-sectional survey carried out among 381 patients attending the General Out-Patient Department (GOPD) of a Teaching Hospital in Nigeria. Interviewer administered questionnaire was used as the research tool and case notes of the patients were used to obtain information on drug adherence. Results: About half of the patients 194 (50.9%) adhered fully with doctor's prescription on the use of drugs for diseases they presented to the hospital. More than three quarters (78.0%) of patients aged 56 years and above adhered fully with prescription compared with 11.1% in the age group 15-25 years. The older patients had better adherence to medication than the younger patients with a statistically significant difference (p = 0.001). Many of the patients with no formal education (69.0%) adhered fully with prescription compared with 28.6% with post secondary education p = 0.001. Conclusion: Health education intervention and active role of health care providers in patients'-provider communication towards addressing the determinants of non-adherence will play a major role in improving adherence to medication
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    Evaluation of CD4+ T Cells in HIV Patients presenting with Malaria at the University of Ilorin Teaching Hospital, Nigeria
    (Mainz University, Germany, 2010) Agbede, O.O.; Ajiboye, T.O.; Kolawole, O.M.; Babatunde, S.A.; Odeigha, L.O.
    ABSTRACT CD4 count is an important immunological marker of disease progression in HIV seropositive patients. This study was carried out to determine the effect of malaria or fever of unknown origin on the population of CD4+ T lymphocytes of HIV seropositive patients attending the highly active antiretroviral therapy (HAART) clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 36 subjects were selected for this study. Ongoing history of fever was used as a case definition for malaria and malaria was confirmed from microscopic examination of thick and thin film of blood sample obtained from the patients during presentation with fever. The CD4 count was evaluated during presentation of fever and post-fever using flow cytometry. There was significant decrease in CD4 count of the patients. However, upon classifying the patients into 2 groups – those that returned to the clinic after a week and those that returned after a month; a significant increase in CD4 count was noticed in the group that returned after a week, while a significant decrease was noticed in the group that returned after a month (at p value of 95 %). Further classification of the patients based on presence of malaria parasite, and body temperature resulted in varying effects on CD4 count post-fever (in the general group, 27 were positive for malaria parasites). Of these 27, there was an increase in CD4 count in 9 (33.3 %). However in the group that returned after a week, all 6 (100 %) that were positive for malaria parasites showed increase in CD4 count. Five (26.3 %) of the 19 patients that had body temperature within the range of 35.5-37.4 °C showed an increase in CD4 count, while 7 (41.2 %) of the 17 patients that had body temperature of 37.5 °C and above showed an increase in CD4 count. The results led to the conclusion that while some components of the immune response to malaria could strengthen the immune system of HIV seropositive patients by increasing their CD4 count, other components will suppress their immunity by decreasing their CD4 count, accelerating the progression to AIDS.
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    Otologic and Audiologic Evaluation among HIV Patients in Ilorin, Nigeria.
    (Nigerian Quarterly Journal of Hospital Medicine. Published by University of Lagos. Medical Society, Lagos, Nigeria., 2013) Alabi, B.S.; Salami, A.K.; Afolabi, O.A.; Aremu, S.K.; Olawumi, H.O.; Odeigha, L.O.; Akande, H.J.
    BACKGROUND: HIV infection is the highest cause of death worldwide and presenting eventually with ENT regions. OBJECTIVE: This study is to determine the prevalence of hearing loss and hearing patterns among adults Nigerians with HIV and causal relationships between CD4+ counts with the degree of hearing impairments. METHODS: This prospective study was carried out among all consecutive HIV positive patients attending the clinic at the University of Ilorin teaching hospital (U.I.T.H.), Ilorin, Nigeria between January and July, 2008. They all had audiological assessments with a pure tone audiometer within the frequency range 250 to 8,000 Hz to determine their hearing thresholds together with their CD+ counts estimations. RESULTS: 89 were evaluated in the age range of 18 to 56 years (Mean 36.4 years, SD of 8.82) and the modal age group was 21-39 years (59.6%), 40-56 years (38.2%).There were 51 males (57.3%) and 38 females (42.7%) with a male/female ratio of 1.3:1.0. Otological symptoms included tinnitus (15.7%), vertigo (15.7%), otalgia (14.6%) and hard of hearing (10%). Examinations showed bilateral serous Otitis media (glue ear) in 58 patients (65.1%) with no affectation of the facial nerves. PTA showed mixed, conductive and SNHL in 32 patients (36%), 20 patients (22.5%), 9 patients (10.1%) respectively and only 15(16.9%) had normal hearing thresholds. The CD4+ counts ranged between 12 to 616. CD4 counts with hearing loss mostly < 300mm3. CONCLUSION: The prevalence of hearing loss is 87% among HIV infected patients, mostly mixed HLwith causal relationships between reduced CD4+ counts of less than 300/mm3 with severity of hearing loss. The hearing loss can interfere with the communication and specific knowledge vital to the development of best practices towards ensuring the inclusion of hearing impaired in HIV/AIDS prevention and treatment programmes.
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    Profile and Outcome of Unilateral Tuberculous Lung Destruction in Ilorin, Nigeria
    (WEST AFRICAN JOURNAL OF MEDICINE, 2011) Fawibe, A. E.; Salami, A. K.; Oluboyo, P. O.; Desalu, O. O.; Odeigha, L.O.
    BACKGROUND: Unilateral tuberculous lung destruction is a serious chronically disabling and often fatal complication of pulmonary tuberculosis. A few previous studies have dealt with some aspects of this entity among Nigerians with pulmonary tuberculosis but these studies may not truly reflect its current trends. OBJECTIVE: To describe the presenting profiles and outcome of unilateral tuberculous lung destruction among patients with pulmonary tuberculosis. METHODS: The study was a chart review of the medical records of adult patients with pulmonary tuberculosis complicated by unilateral lung destruction seen between January 1999– December 2008. Data extracted included demographic, and outcome of treatment. The clinical features, sputum results and illustrative cases are presented. RESULTS: Unilateral lung destruction complicated 74(1.3%) of 5,926 pulmonary tuberculosis cases seen over the review period. Most cases occurred in males [45(60.8%)] and they were predominantly [51(68.9%)] below 40 years of age. Most of them [52(70.2%)] presented after six months of symptoms. Forty-seven (63.5%) of them had had previous exposure to antituberculosis drugs. The left lung was affected in 49 (66.2%) patients. Only 25 (33.8%) of them were cured while the adjusted mortality rate was 25.5%. Male gender, presence of dyspnoea on mild exertion and right ventricular failure were significantly associated with increased mortality. CONCLUSION: Unilateral tuberculous lung destruction has unacceptably high mortality rate which can be prevented by patient presenting early to the hospital, prompt diagnosis and strict adherence to the standard treatment. WAJM 2011; 30(2): 130–135.