Browsing by Author "Nwachukwu, I.D"
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Item Inhibitory properties of Bambara groundnut protein hydrolysate and peptide fractions against angiotensin converting enzymes, rennin and free radicals(Published by Society of Chemical Industry, 2016) Arise, A.K; Alashi, A.M; Nwachukwu, I.D; Malomo, S.A.; Aluko, R.E; Amonsou, E.OBACKGROUND:Anincreasedrateofhighbloodpressurehasledtocriticalhumanhypertensiveconditionsinmostnations.Inthepresentstudy,bambaraproteinhydrolysates(BPHs)obtainedusingthreedifferentproteases(alcalase,trypsinandpepsin)and theirpeptidefractions(molecularweight:10,5,3and1kDa)wereinvestigatedforantihypertensiveandantioxidantactivities. RESULTS:Alcalasehydrolysatecontainedthehighestamountoflowmolecularweight(LMW)peptidescomparedtopepsinand trypsinhydrolysates.LMWpeptidesfractions(<1kDa)exhibitedthehighestinhibitoryactivityagainstangiotensin-converting enzyme (ACE) for all the enzymes hydrolysates. For renin inhibition, alcalase hydrolysate showed the highest inhibition at 59%comparedtootherhydrolysatesandtheircorrespondingmembranefractions.Theantioxidantpowerofbambaraprotein hydrolysates and peptide fractions was evaluated through the inhibition of linoleic acid peroxidation and ABTS scavenging activity.Amongthehydrolysates,alcalaseexhibitedthehighestinhibitionoflinoleicacidoxidation.Furthermore,allBPHswere abletoscavengeABTS•+ to a three fold greater extent compared to the isolate. CONCLUSION: BPH and LMW peptide fractions could potentially serve as useful ingredients in the formulation of functional foods and nutraceuticals against high blood pressure and oxidative stress