Browsing by Author "Nnabuike, G. G."

Now showing 1 - 4 of 4
  • Item
    Mixed Isonicotinylhydrazide – pyridoxine Metal omplexes: Synthesis, Characterization and Antimicrobial activity
    (The Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2016-05-07) Lawal, M,; Obaleye, J. A.; Lawal, A.; Bamigboye, M. O.; Rajee, A. O.; Babamale, H. F.; Nnabuike, G. G.
    Some mixed metal complexes of isonicotinylhydrazide – pyridoxine have been synthesised and characterised by physical and spectroscopic studies such as melting point, conductivity measurement, TLC, FT-IR and UV-visible spectroscopy. The antimicrobial activities of the metal complexes were investigated against some clinical isolates of Eschericha Coli, Klebsiella Pneumonia, Pseudomonas aureginosa and Stapylococcus species using the agar well diffusion method. The result of the spectroscopic studies revealed that both isoniazid and pyridoxine behave as neutral bidentate ligands. The Isonicotinylhydrazide ligand coordinated through the carboxyl oxygen and amine nitrogen while pyridoxine coordinated through the oxygen of the hydroxyl group and nitrogen of the pyridine group. The result of antimicrobial activity shows that the metal complexes displayed higher inhibitory activity against the tested organisms than the parent ligands
  • Item
    Preparation, Characterization and Biological Studies of Metal Complexes of Mixed Ligands of Nicotinamide and Metronidazole
    (Nigerian Society of Biochemistry and Molecular Biology, 2017-10-25) Lawal, A.; Ayanwale, P. A.; Rajee, A. O,; Bamigboye, M. O,; Saadu, H. O.; Lawal, M.; Babamale, H. F.; Nnabuike, G. G.; Yunus Issa, M. T.; Amolegbe, S. A.
    The Mn2+, Fe2+, Cu2+, Co2+, Zn2+ and Ni2+ complexes of mixed nicotinamide and metronidazole were prepared and characterized using solubility, melting point, conductivity measurement, CHNO (carbon, hydrogen, nitrogen, oxygen) elemental analysis, powder X-ray diffraction and infrared spectroscopy . The results of the physical and spectroscopic data confirm the formation of the complexes. For nicotinamide, coordination of the metal to the ligands occurred through the nitrogen of the pyrimidine group, while for mertonidazole, coordination took place through the nitrogen of the amine group. The antibacterial activity of the complexes was carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella spp, Escherichia coli and Candida spp. Only Cu(II) mixed complex had high inhibitory activity against all three bacteria species. The results of antifungal activity show that all the complexes have no inhibitory activity against the two fungi species compared with the corresponding ligands
  • Item
    Solvent Free Synthesis, Characterization and Antibacterial Studies of Urea and Thiourea Metal Complexes
    (Faculty of Pure and Applied Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria, 2016-10-25) Lawal, A.; Nnabuike, G. G.; Obaleye, J. A.; Bamigboye, M. O.; Lawal, M.
    Solvent-based synthesis as well as Liquid Assisted Grinding (LAG) synthesis of urea and thiourea complexes is described for comparison purposes. The resulting complexes of both methods of syntheses were characterized using melting points, conductivity values, spectroscopic data (IR, UV-Visible) and antibacterial activity study. Spectral data of the complexes synthesized by LAG method was found to be similar to those synthesized by conventional synthesis. All the ligands were found to be monodentate and all the complexes exhibited tetrahedral and square-planar geometry. The LAG method was carried out by introducing a few drops of solvent. The method is faster with a better yield compared to solvent- based method. The antimicrobial study of the ligands and the complexes was carried out against Gram-positive (Staphylococus aureus and Bacilius subtilis) and Gram-negative bacteria (Eschericia. coli). The antibacterial activity study of the complexes showed that they possessed higher inhibitory activity than their parent ligands at concentration of 200 μgml-1.
  • Item
    Synthesis, Characterization and Biological activity of Metal Complexes Mixed Citric acid and Amodiaquine
    (Faculty of Science, Bayero University Kano. Nigeria, 2017-05-20) Lawal, A.; Olowude, S.; Bamigboye, M. O.; Sa`ad, H. O.; Nnabuike, G. G.; Yunus-Issa, M. T.; Amolegbe, S. A.
    A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been synthesized and characterised using microanalytical technique , elemental analysis, FT-IR spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data revealed that both amodiaquine and citric acid acted as bidentate ligands in the ir mode of coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry. Percentage composition and magnetic Bohr moment data indicated that all metal complexes were paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out against g(+)Pseudomonas aeruginosa, g(+)E. coli, g( +)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The citric acid and amodiaquine result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception of the Cu(II) complex having inhibitory zones ranging from 1-0-1. 3 , 0 . 7 - 0 . 9 at 200 ppm respectively. Moreover, the free ligands were found being less active compared with their mixed complexes.