Browsing by Author "Njinga, Stan"

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    Antifungal Screening of Ceiba petandra and Lannea kerstingii Stem Bark Extract Cream Formulations
    (Journal of Pharmaceutical Sciences and Pharmacy Practice, 2014) Kola-Mustapha, Adeola Tawakalitu; Aremu, Olusola; Njinga, Stan; Ayotunde, Hameedat
    Aim: Evaluation of the potential application of Ceiba petandra and Lannea kerstingii creams in the management of topical dermatophytic infections. Methodology: Antifungal activities of methanolic extract of Ceiba petandra, ethyl acetate extract of Lannea kerstingii stem barks, their combinations and their cream formulations were studied by the agar well diffusion method. Clinical isolates of Trichophyton rubrum and Trichophyton mentagrophytes were used as test organisms, while modified Aqueous Cream (BP) was used as the cream base. The extracts were incorporated into modified aqueous cream at concentrations 0.4, 0.8, 1.6, 2.4 and 3.2% w/w. Griseofulvin and ketoconazole cream were used as reference antifungal agents. Results: Extracts of Ceiba petandra, Lannea kerstingii and their combinations exhibited significant levels of antifungal activity (p < 0.05) against the test dermatophytes. Diameters of inhibition zones ranged from 11.00 ± 0.29 mm to 24.30 ± 0.02 mm for the extracts and 3.00 ± 0.82 mm to 26.33 ± 0.94 mm for the cream formulations, as extract concentrations increased from 0.4 to 3.2% w/w. More inhibitory activities were exerted against Trichophyton rubrum compared to Trichophyton mentagrophytes. Conclusion: Stem bark extracts of Ceiba petandra and Lannea kerstingii and their cream formulations possess useful antifungal activities against some causative agents of dermatophytoses.