Browsing by Author "Nafiu AB"

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    Low Glycaemic Index Foods, a Better Option for Pre-exercise Meals.
    (College of Medicine, Ambrose Alli University, Edo, Nigeria, 2017-12) Ojulari LS; Ayinde TO; Kadir RE,; Biliaminu SA; Nafiu AB; Ayinla MT; Abdulazeez FI; Jimoh-Abdulghaffaar HIidaayah Oluwamayowa; Imam-Fulani AO; Fatai RA
    Background: The glycaemic index (GI) of food ingested before exercise influences substrate utilization during exercise and may affect performance during exercise. Aim: This study determined the impact of low(LGI) and high GI (HGI) foods on post exercise blood glucose and lactate levels. Methods: 24 male subjects meeting defined requirements were recruited to participate in the experiment. Data from 17 individuals were finally analyzed following exclusion of ineligibility of 7 individuals. They were randomly selected into 3 groups; group 1- (Control n=5, distilled water), group 2 (n=6, 100 g of cooked brown beans), and group 3 (n=6, 100 g of white bread). Postprandial and post-exercise blood glucose level was measured by the glucose oxidase method and Blood lactate concentration was also determined. Data collected was analysed using statistical package for social sciences and results were expressed as mean and standard error of mean. Results: A significant increase (p<0.05) in postprandial blood glucose level before exercise in both LGI and HGI fed groups was recorded when compared to control. After exercise, blood glucose level was significantly increased (p<0.05) in LGI fed group when compared to control, with a significant decrease (p<0.05) in blood glucose in the HGI fed group when compared to group 2. Postprandial and post-exercise lactate levels were significantly increased in both groups. Conclusion: LGI food is capable of providing more energy (stored) which can later be utilised during later stage of a prolonged exercise, hence, consumption of such food is suggested to athletes involved in long duration exercises
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    Sub-chronic Use of Levonorgestrel Alters Tissue Lipid Profile, Liver Function and Selected Tissue Cytoarchitecture in Female Wistar Rats
    (Journal of Biomedical and Applied Sciences, 2022) Abdulrahim HA; Fatoki JO; Oyewo EB; Nafiu AB; Omeiza NA; Adekunle AS
    ABSTRACT Background and Objectives: Oral levonorgestrel is a post coitus contraceptive used to prevent unintended pregnancies. The uncontrolled availability of levonorgestrel over-the-counter for sexually active youth, as well as the increasing potential consequences of side effects with frequent use, necessitates research into the effects of repeated levonorgestrel use on selected tissues' cytoarchitectures and biomarkers in female Wistar rats. Methods: Twenty rats (140 ± 20 g) were randomized into four groups: control received 0.2 mL/kg normal saline while others were exposed to oral levonorgestrel at 0.002 mg/kg, 0.004 mg/kg and 0.008 mg/kg, 3 times weekly at 48-hour interval for six weeks. Results: Levonorgestrel increased hepatic total cholesterol, phospholipids and malondialdehyde; renal and cardiac total cholesterol were also found to be elevated in high dose (0.008 mg/kg) levonorgestrel treated rats. Regardless of administered dose, levonorgestrel has a varying effect on tissue triglycerides and GSH and increases serum AST and ALT.. Furthermore, levonorgestrel significantly altered the histoarchitecture of selected tissues in a dose-dependent manner, indicating hepatic karyorrhexis, renal congestion, loss of cortical glomeruli in the kidney, cardiac hypertrophy, endometrial epithelial hypoplasia, disruption of glycoprotein zona pellucida, and uterine glandular atrophy. Conclusion: These findings suggest that levonorgestrel is toxic at non-pharmacological doses by altering tissue lipid profiles and inducing cellular injuries through oxidative and non-oxidative mechanisms. Keywords: Levonorgestrel; Lipid Profile; Liver Function; Cellular Injuries; Oral Contraceptives.