Browsing by Author "Musa, K. Y."

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    ANTI-INFLAMMATORY AND ANALGESIC POTENTIALS OF THE ROOT BARK EXTRACT OF SABA COMORENSIS (BOJER) PICHON (APOCYNACEAE) USED IN NIGERIAN TRADITIONAL MEDICINE
    (Nigerian Journal of Pharmaceutical Sciences, 2020-03) Attah, F. A; Chukwudulue, U. M.; Diyaolu, O. A.; Njinga, N. S.; Abdullahi, A. A.; Agunu, A.; Musa, K. Y.
    Painful and inflammatory diseases such as arthritis, backache, headaches, asthma and peptic ulcer disease are widespread and highly prevalent. The existing drugs for these conditions are liable to sub-optimal efficacy, intolerable adverse effects, prohibitive costs or limited availability. This scenario calls for renewed search for additional anti-inflammatory and analgesic agents. Hence, in line with the Traditional uses of plants, this study investigated the ethanol extract of Saba comorensis (Bojer ex. A.DC.) Pichon, for its safety, anti-inflammatory and analgesic effects in rodents using standard experimental protocols. The LD50 (i.p.) for the ethanol extract obtained from the geometric mean of doses was 770 mg/kg. Compared with the negative controls, the ethanol extract exhibited significant (p<0.05) and dose-dependent anti-inflammatory, ulcerogenic and dose-independent analgesic effects, while the petroleum extract did not induce any significant ulcerogenic effects. These findings suggest Saba comorensis ethanol root extract may be relatively safe and possesses anti-inflammatory and analgesic properties and may justify its use as traditional remedy for painful and inflammatory conditions. There is the need to investigate the study plant further for anti-inflammatory and analgesic drug discovery