Browsing by Author "Mohammed M. Suleiman"

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    Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
    (Springer Science and Business Media LLC, 2020-09-25) Ganiu Jimoh Akorede; Suleiman Folorunsho Ambali; Mikail Garba Hudu; Mohammed M. Suleiman; Kolawole Yusuf Suleiman; Halimat Amin Abdulrahim; Lukman Oladimeji Raji; Isiaku AbdulMajeed
    Carbamazepine is an effective chemotherapeutic agent used to manage individual with epilepsy and trigeminal neuralgia. Chronic use of carbamazepine has been incriminated to cause reproductive disorders. The present study investigates the protective property of Moringa oleifera leaves methanolic extract on chronic carbamazepine-evoked reproductive toxicity in male Wistar rats. Forty male Wistar rats (150–260 g) were randomly separated into four groups with 10 rats, given distilled water (2 ml/kg), M. oleifera (200 mg/kg), carbamazepine (20 mg/kg) and M. oleifera accompanied with carbamazepine, after 30 min. The treatments were administered once in a day for 15 weeks via gavage. The pituitary and testis were evaluated for parameters measuring oxidative challenge, sperm characteristics and histological changes. Sex hormone concentrations were also evaluated from sera samples. The result of the phytochemical analysis shows that M. oleifera leaves extract contain total phenolics (7.8%) and flavonoids (22.23%), which are considered higher in the plant. The results also revealed that exposure to M. oleifera leaves mitigates the disruption in oxidative stress parameters, sex hormone concentration, sperm characteristics and histological changes. This study revealed that chronic carbamazepine administration evokes oxidative stress, partly involved in the alterations of concentration of sex hormones, sperm characteristics and histoarchitecture of pituitary gland and testes. Treatment with leaf extract of M. oleifera protects against the adverse reproductive consequences of long-term exposure to CBZ, due to its antioxidant property
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    Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
    (Accelerating the world's research., 2020) Ganiu Jimoh Akorede; Mikail Garba Hudu; Suleiman Folorunsho Ambali; Mohammed M. Suleiman; Kolawole Yusuf Suleiman; Abdulrahim Amin Halimat; Lukman Oladimeji Raji; Isiaku AbdulMajeed
    Carbamazepine is an effective chemotherapeutic agent used to manage individual with epilepsy and trigeminal neuralgia. Chronic use of carbamazepine has been incriminated to cause reproductive disorders. The present study investigates the protec- tive property of Moringa oleifera leaves methanolic extract on chronic carbamazepine-evoked reproductive toxicity in male Wistar rats. Forty male Wistar rats (150–260 g) were randomly separated into four groups with 10 rats, given distilled water (2 ml/kg), M. oleifera (200 mg/kg), carbamazepine (20 mg/kg) and M. oleifera accompanied with carbamazepine, after 30 min. The treatments were administered once in a day for 15 weeks via gavage. The pituitary and testis were evaluated for parameters measuring oxidative challenge, sperm characteristics and histological changes. Sex hormone concentrations were also evaluated from sera samples. The result of the phytochemical analysis shows that M. oleifera leaves extract contain total phenolics (7.8%) and flavonoids (22.23%), which are considered higher in the plant. The results also revealed that exposure to M. oleifera leaves mitigates the disruption in oxidative stress parameters, sex hormone concentration, sperm characteristics and histological chang- es. This study revealed that chronic carbamazepine administration evokes oxidative stress, partly involved in the alterations of concentration of sex hormones, sperm characteristics and histoarchitecture of pituitary gland and testes. Treatment with leaf extract of M. oleifera protects against the adverse reproductive consequences of long-term exposure to CBZ, due to its antioxidant property.
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    Effect of daflon-500®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats
    (Springer Science and Business Media LLC, 2022-01-10) Aishat O. Olatunji; Joseph O. Ayo; Mohammed M. Suleiman; Suleiman F. Ambali; Muftau Shittu; Ganiu J. Akorede; Lukman O. Raji; Jamila A. Atata; Khalid T. Biobaku; Mistura O. Azeez
    Alteration of redox status is one of the molecular pathways commonly associated with pesticide toxicity. Antioxidants, including those obtained from plant phenolics, have been shown to mitigate pesticide-induced cellular injury. The present study was aimed at evaluating the efect of dafon-500®, a favonoid compound on sub-chronic chlorpyriphos-evoked changes in antioxidant and biochemical parameters in the hypophysis and testes of adult male rats. Twenty-fve male albino rats were randomly divided into 5 groups of 5 animals each. Group I (DW) received distilled water (2 ml/kg); group II (SO) was dosed with soya oil (2 ml/kg); Group III (DAF) received dafon-500® at 1000 mg/kg ̴ 1/5th of LD50 (≥5000 mg/kg); group IV (CP) was administered chlorpyriphos at 7.74 mg/kg ̴ 1/10th of LD50 (77.4 mg/kg) while group V (DAF+CP) was previously treated with dafon-500® (1000 mg/kg) and then exposed to CP (7.74 mg/kg), 30 min later. Daily oral regimen administration was done for 60 days after which the animals were sacrifced by cervical venesection after light chloroform anesthesia. The hypophysis and testicular tissues were harvested, and their homogenates were analyzed for malondialdehyde, catalase and superoxide dismutase, and acetylcholinesterase levels. A signifcant increase in the hypophysis and testicular MDA concentrations, coupled with a decrease in the SOD, CAT, and AChE activities were observed in the CP group. The levels of these oxidative and biochemical parameters were alleviated in the group pretreated with Dafon-500®. Results of this study demonstrated that pre-treatment with Dafon-500® mitigated CP-induced alterations in oxidative and biochemical parameters apparently due to the antioxidant efect of the favonoid compound.