Browsing by Author "Madaki, F. M."

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    Differential spectrophotometric determination of levofloxacin in bulk and pharmaceutical formulations
    (The Nigerian Journal of Pharmacy, 2026) Abdullahi, S. T.; Dada, F. O.; Eniayewu, O. I.; Bamidele, O. D.; Soyinka, J. O.; Sanusi, A.; Madaki, F. M.
    Background: Levofloxacin, which is pharmaceutically available as a hemihydrate (C18H20FN3O4·1/2H2O), is the optical S-(-) isomer of ofloxacin. This study proposed and validated a differential ultraviolet spectrophotometric method for determining levofloxacin in bulk and pharmaceutical formulations, based on the principle that levofloxacin exhibits characteristic spectral shifts with changes in the pH of the assay solvents. Methods: Two solutions of levofloxacin in 0.1N HCl and 0.1N NaOH at the same concentration served as the test and reference solutions (∆D1), and as the reference and test solutions (∆D2). The amplitude values were calculated and plotted against concentrations. Results: Beer’s law was obeyed, and the calibration curves were found to be linear over the concentration range of 4–20 μg/mL, with an excellent correlation coefficient (r > 0.9999) for both scenarios at the observed absorption maxima and minima of 228 and 298 nm for ∆D1, and 257 and 348 nm for ∆D2. Accuracy studies showed recoveries close to 100% (100.17–100.35%) with low RSD values (≤1.78%), demonstrating excellent accuracy. Precision was also satisfactory, with intraday precision and robustness RSD values generally below 2%. Sandell’s sensitivity (0.0113–0.0166 µg·cm⁻²) indicated adequate analytical sensitivity. Conclusion: The results indicate that the proposed analytical method is accurate, specific, and precise, and can be used for routine analysis of levofloxacin hemihydrate in bulk and pharmaceutical formulations.
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    Differential spectrophotometric determination of levofloxacin in bulk and pharmaceutical formulations.
    (The Nigerian Journal of Pharmacy, 2026-04) Abdullahi, S. T.; Dada, F. O.; Eniayewu, O. I.; Bamidele, O. D.; Sanusi, A.; Madaki, F. M.; Soyinka, J. O.
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    Phytochemical, nutritional and antioxidant properties of pumpkin leaf and fruit (Cucurbita maxima) from Bosso-Niger State, Nigeria.
    (2024) Madaki, F. M.; Abdulkadir, A.; Abubakar, A.; Hamza, R. U.; Muhammad, H. K.; Abdullahi, S. T.; Tanimu, N. A.
    Cucurbita maxima commonly known as pumpkin, is widely cultivated throughout the world for use as vegetable as well as medicine plant. Phytochemical analysis, nutritional and antioxidant properties of Cucurbita maxima leaf and fruit methanol extracts were determined in this study. The phytochemical and proximate analysis were performed according to standard method. The antioxidant activity was carried out using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP). The qualitative phytochemical screening of Cucurbita maxima fruit and leaf revealed that Alkaloids (9.07±0.01), Tannins (4.32±0.01), and terpenoids (8.64±0.01) were found to have the highest concentration in the fruit while saponins (8.64±0.01), flavonoids (3.86±0.01) and steroids (3.86±0.01) were found to be higher in the leaf. The proximate composition of pumpkin leaf and fruit showed significant difference in moisture (10.65 ± 0.04) (8.07 ± 0.01), fibre (2.03 ± 0.03) (4.16 ± 0.03), ash contents (3.08 ± 0.08) (2.17 ± 0.05), fat (5.12 ± 0.20) (2.07 ± 0.20), (67.99± 0.03) (73.12± 0.01), and protein (10.580.06) (9.72± 0.07) of the pumpkin leaf and fruit respectively. Both extracts exhibited a dose dependent antioxidant activity in DPPH and FRAP assays. The Cucurbita maxima extracts exhibited significantly (p < 0.05) lower antioxidant activities compared to the standard (ascorbic acid). The results of mineral analysis of pumpkin shows that potassium (48.79±0.01 mg/g) and iron (33.60±0.00 mg/g) contents were higher in the pumpkin methanol fruit extract, followed by sodium (17.88±0.04 mg/g) while potassium (41.57±0.04 mg/g) and zinc (22.30±0.15 mg/g) was the most prominent element followed by iron (8.14±0.00 mg/g) in the pumpkin methanol leaf extract. These results suggest that Cucurbita maxima could serve as a valuable source of nutrients and antioxidants, particularly in resource-constrained communities. Keywords: Cucurbita maxima, Phytochemicals, Proximate composition, Antioxidant properties and Mineral analysis
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    Spectrophotometric determination of amodiaquine in amodiaquine-containing tablets.
    (The Nigeria Association of Pharmacy in Academia., 2025) Abdullahi, S. T., Ogunniyi, O. M., Eniayewu, O. I., Bamidele, O. D., Sanusi, A., Madaki, F. M., Njinga, N. S., & Bakare-Odunola, M. T.; Ogunniyi, O. M.; Eniayewu, O. I.; Bamidele, O. D.; Sanusi, A.; Madaki, F. M.; Njinga, N. S.; Bakare-Odunola, M. T.