Browsing by Author "Lukman Oladimeji Raji"

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    Anti-anaemic effects of leaf protein concentrate of Eremomastax speciosa (Hochst) Cufod. on some blood parameters of male Sprague-Dawley rats exposed to phenylhydrazine-induced anaemia
    (African Journals Online (AJOL), 2023-11-23) Chukwuemeka Onyekachi Nwaigwe; Chioma Uchenna Nwaigwe; Uchechukwu Chukwudi Obiekwe; Lukman Oladimeji Raji
    This study investigated the effects of leaf protein concentrate (LPC) of Eremomastax speciosa (Hochst.) Cufod on some haematological and serum profile of 45 male Sprague-Dawley rats divided into nine groups of five rats per group. The rats received fresh drinking water daily, with feed at 85% of ad-lib. The standard haematinic used was Ranferon-12®, at the dose of 0.3ml/kg body weight. The resultant groups were; Group1 (Positive control, received commercial feed) Group 2 (phenylhydrazine only or negative control), Group 3 (anaemia +haematinic), 4, 5 and 6 (anaemia +100 mg/kg, 200 mg/kg and 400 mg/kg of LPC respectively), Groups 7, 8, 9 (Untreated (or UT) +100 mg/kg, 200 mg/kg and 400 mg/kg of LPC respectively). The LPC was administered orally to the designated groups, while the controls received distilled water in place of the LPC. Anaemia was induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Samples for haematological and biochemical analysis were collected on days 9, 21 and 28 of the experiment. Results showed that the groups supplemented with LPC were better in terms of the haematology and serum biochemical values compared to the negative control, and this strongly supported the traditional use of E. speciosa leaf in the treatment of anaemia.
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    Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
    (Springer Science and Business Media LLC, 2020-09-25) Ganiu Jimoh Akorede; Suleiman Folorunsho Ambali; Mikail Garba Hudu; Mohammed M. Suleiman; Kolawole Yusuf Suleiman; Halimat Amin Abdulrahim; Lukman Oladimeji Raji; Isiaku AbdulMajeed
    Carbamazepine is an effective chemotherapeutic agent used to manage individual with epilepsy and trigeminal neuralgia. Chronic use of carbamazepine has been incriminated to cause reproductive disorders. The present study investigates the protective property of Moringa oleifera leaves methanolic extract on chronic carbamazepine-evoked reproductive toxicity in male Wistar rats. Forty male Wistar rats (150–260 g) were randomly separated into four groups with 10 rats, given distilled water (2 ml/kg), M. oleifera (200 mg/kg), carbamazepine (20 mg/kg) and M. oleifera accompanied with carbamazepine, after 30 min. The treatments were administered once in a day for 15 weeks via gavage. The pituitary and testis were evaluated for parameters measuring oxidative challenge, sperm characteristics and histological changes. Sex hormone concentrations were also evaluated from sera samples. The result of the phytochemical analysis shows that M. oleifera leaves extract contain total phenolics (7.8%) and flavonoids (22.23%), which are considered higher in the plant. The results also revealed that exposure to M. oleifera leaves mitigates the disruption in oxidative stress parameters, sex hormone concentration, sperm characteristics and histological changes. This study revealed that chronic carbamazepine administration evokes oxidative stress, partly involved in the alterations of concentration of sex hormones, sperm characteristics and histoarchitecture of pituitary gland and testes. Treatment with leaf extract of M. oleifera protects against the adverse reproductive consequences of long-term exposure to CBZ, due to its antioxidant property
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    Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
    (Accelerating the world's research., 2020) Ganiu Jimoh Akorede; Mikail Garba Hudu; Suleiman Folorunsho Ambali; Mohammed M. Suleiman; Kolawole Yusuf Suleiman; Abdulrahim Amin Halimat; Lukman Oladimeji Raji; Isiaku AbdulMajeed
    Carbamazepine is an effective chemotherapeutic agent used to manage individual with epilepsy and trigeminal neuralgia. Chronic use of carbamazepine has been incriminated to cause reproductive disorders. The present study investigates the protec- tive property of Moringa oleifera leaves methanolic extract on chronic carbamazepine-evoked reproductive toxicity in male Wistar rats. Forty male Wistar rats (150–260 g) were randomly separated into four groups with 10 rats, given distilled water (2 ml/kg), M. oleifera (200 mg/kg), carbamazepine (20 mg/kg) and M. oleifera accompanied with carbamazepine, after 30 min. The treatments were administered once in a day for 15 weeks via gavage. The pituitary and testis were evaluated for parameters measuring oxidative challenge, sperm characteristics and histological changes. Sex hormone concentrations were also evaluated from sera samples. The result of the phytochemical analysis shows that M. oleifera leaves extract contain total phenolics (7.8%) and flavonoids (22.23%), which are considered higher in the plant. The results also revealed that exposure to M. oleifera leaves mitigates the disruption in oxidative stress parameters, sex hormone concentration, sperm characteristics and histological chang- es. This study revealed that chronic carbamazepine administration evokes oxidative stress, partly involved in the alterations of concentration of sex hormones, sperm characteristics and histoarchitecture of pituitary gland and testes. Treatment with leaf extract of M. oleifera protects against the adverse reproductive consequences of long-term exposure to CBZ, due to its antioxidant property.
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    Changes in Semen, Hormonal profile and Testicular Morphology of West African Dwarf Goat Bucks treated with Danazol
    (Turkish Science and Technology Publishing (TURSTEP), 2020-12-26) Lukman Oladimeji Raji; Mohammed Babashani; Ganiyu Jimoh Akorede; Aishat O Olatunji; Fatima Sanusi; Yusuf Idris; Khalid Tahlia Biobaku
    This study was carried out to investigate the changes in semen characteristics, hormonal profile and testicular morphometry of West African Dwarf (WAD) goat bucks treated with danazol. For this purpose, eighteen matured WAD bucks average of about two years were randomly divided into groups A, B and C comprising of six bucks per group. Group A was the control while B and C bucks were given danazol at a dose rate of 20mg/kg body weight orally daily for four weeks. The group B bucks‘ testes were harvested thereafter for gross and histo-morphometric studies while those of group C were left intact but danazol treatment was withdrawn for four more weeks. The bucks‘ semen samples (collected by electro-ejaculation) and hormonal samples (taken via the jugular vein) were analyzed. The semen characteristics studied included color, volume, mass activity, motility, percentage normal live-dead ratio, morphology and concentration; while the hormones studied included testosterone, follicle stimulating hormone and luteinizing hormone. Results show that there were significant decreases in semen characteristics of group B and C bucks compared with those of group A in the first four weeks. The semen characteristics of the group C bucks were reversed to normal range (similar to those of group A bucks) two weeks after danazol treatment was withdrawn. Similar results were observed with the hormonal studies. In conclusion, danazol caused a reversed reduction in sperm cells characteristics suggesting its possible use as a contraceptive in WAD goat bucks.
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    Comparative Studies of Some Biochemical Characteristics of Seminal Plasma in Wild and Cultured Male Catfish (<em>Clarias gariepinus</em>), Burchell, 1822 Broodstock
    (Sri Lanka Journals Online (JOL), 2023-01-01) Olatunji Yusuf Yusuf; Wasiu Adeyemi Jimoh; Lukman Oladimeji Raji; Faidat Azeez
    Purpose: In aquaculture, the most important aspect to consider is ensuring the development of valuable offspring by using high-quality gametes from fish broodstock. This research aims to compare the biochemical constituents of seminal plasma in both wild and cultured Clarias gariepinus broodstock. Research Method: Apparently healthy adult male Clarias gariepinus (n=9, 900±300g mean weight per fish type (wild or cultured), 49±8.5cm mean total length) were collected from fishermen on the Oshin River, Nigeria for the wild samples and from a reputable fish farm in Ilorin and examined for some seminal plasma’s biochemical parameters following standard procedures. T-test statistics were used to compare the differences between classes. Findings: Higher values of most of the semen biochemical compositions were recorded among the cultured Clarias gariepinus with significant variations (p<0.05) recorded in the mean values of total cholesterol, high-density lipoprotein-cholesterol (HDL-Cholesterol), low-density lipoprotein-cholesterol (LDLCholesterol), uric acid, Aspartate Aminotransferase (AST), total bilirubin, albumin, potassium, chloride and urea. Creatinine, glucose, sodium, and triglycerides, on the other hand, did not vary significantly (p>0.05) between cultured and wild Clarias gariepinus semen. Originality/ Value: The current study’s findings on biochemical compositions could lead to more effective gamete management, higher yields, and improved semen suitability for short-term storage.
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    Scrotal Circumference as a Parameter of Breeding age for West African Dwarf Bucks.
    (Turkish Science and Technology Publishing (TURSTEP), 2015-08-10) Lukman Oladimeji Raji; Oluwatoyin Oluwasola Ajala
    This study evaluated the correlation between scrotal circumference (SC), body weight (BW) and body condition score (BCS) in relation to breeding age in West African Dwarf (WAD) bucks. A total of 320 WAD bucks from birth to 15 months of age from various farms in Ibadan, Nigeria, were studied. They were grouped as A-birth to 3, B-4 to 7, C-8 to 11 and D-12 to 15 months old respectively, comprising of 80 bucks per group. Semen was collected from 10 randomly selected bucks in each group and analysed. Results showed positive correlation between SC and age; SC increased with age; and at about 8 months of age and over, a consistent SC of 17 cm–18 cm was observed. BW also increased with age; BW significantly affected SC. Also, at 8 months of age and over, SC of 17 cm-18 cm was observed from 9 kg BW and above. However, the correlation between SC and BCS was low and not significant. Semen analysis revealed the best semen quality for groups C and D bucks. In conclusion, we suggest that WAD bucks of 8 months and above, with at least SC between 17 cm–18 cm and of over 9 kg BW, could be used to breed does successfully on the farm.
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    Scrotal Circumference as a Parameter of Breeding age for West African Dwarf Bucks.
    (Turkish Science and Technology Publishing (TURSTEP), 2015-08-10) Lukman Oladimeji Raji; Oluwatoyin Oluwasola Ajala
    This study evaluated the correlation between scrotal circumference (SC), body weight (BW) and body condition score (BCS) in relation to breeding age in West African Dwarf (WAD) bucks. A total of 320 WAD bucks from birth to 15 months of age from various farms in Ibadan, Nigeria, were studied. They were grouped as A-birth to 3, B-4 to 7, C-8 to 11 and D-12 to 15 months old respectively, comprising of 80 bucks per group. Semen was collected from 10 randomly selected bucks in each group and analysed. Results showed positive correlation between SC and age; SC increased with age; and at about 8 months of age and over, a consistent SC of 17 cm–18 cm was observed. BW also increased with age; BW significantly affected SC. Also, at 8 months of age and over, SC of 17 cm-18 cm was observed from 9 kg BW and above. However, the correlation between SC and BCS was low and not significant. Semen analysis revealed the best semen quality for groups C and D bucks. In conclusion, we suggest that WAD bucks of 8 months and above, with at least SC between 17 cm–18 cm and of over 9 kg BW, could be used to breed does successfully on the farm.