Browsing by Author "Lewu, F. S."

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    Kolaviron ameliorates toxic effects of aluminum chloride on the hippocampus of fetal Wistar rats in utero: Biochemical and ultrastructural observations.
    (Jagadguru Sri Shivarathreeshwara University, Mysore., 2021-12-17) Lewu, F. S.; Enaibe, B. U.
    BACKGROUND: This study was designed to investigate the biochemical and ultrastructural effects of kolaviron (Kv) on the hippocampus of fetal Wistar rats exposed to aluminum chloride (AlCl3) toxicity in utero. MATERIALS AND METHODS: Fifty female Wistar rats were selected at random and mated. Following confirmation of mating, pregnant rats were assigned into five groups (n = 5). Controls: Group A received distilled water; Group B: 0.6 ml of corn oil; Group C: 200 mg/kg of Kv; Group D: 100 mg/ kg of AlCl3 and Group E 100 mg/kg of AlCl3 and 200 mg/kg of Kv. Administration was done from days 8-10 and 15-17 of gestation during the 2nd and 3rd weeks respectively. Biochemical analyses were investigated to assess oxidative stress levels, while transmission electron microscopy (TEM) examined ultrastructural changes. Pregnant animals were sacrificed on day 20 of gestation; fetuses, their brains, and hippocampi were excised, respectively. Hippocampal tissues of fetuses were homogenized in 0.25 M of sucrose solution for biochemical assay while some were fixed in 2.5% phosphate‑buffered saline‑based glutaraldehyde for TEM. RESULTS: Elevated levels of Al, malondialdehyde, nitric oxide, and interleukin 6 were observed in the hippocampi of fetuses whose mothers received AlCl3. TEM revealed loss of nuclear membrane and increased condensation of chromatin materials in the same group. However, significant reduction of these enzymes including improved ultrastructural alterations were observed in the fetal hippocampus of the AlCl3 + Kv‑treated group. CONCLUSION: This study showed that Kv significantly reduced neurodegenerative effects induced by AlCl3 in the hippocampii of fetal Wistar rats in utero probably owing to its antioxidant and anti‑inflammatory properties.
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    Muscle Tissues: In Histology Practical Manual
    (Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin., 2024-04) Lewu, F. S.; Ibiyeye, R. Y.; Danwahab, O. A.; Imam, A.; Jaji-Sulaimon, R.; Sulaimon, F. A.; Ajao, M. S.; Omotoso. G. O.
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    Radiological assessment of the calcaneal angles of Kwara populace: A retrospective study.
    (Publication of Journal of Jagadguru Sri Shivarathreeshwara University, Mysore., 2020) Alabi, A. S.; Mohammed, B. E.; Lewu, F. S.; Neku, O. R.; Kareem, S. B.; Oyewopo, A. O.; Adigun, F. M.
    INTRODUCTION: Estimation of sex from different dimensions has considerable forensic value, for the identification of human remains, in the estimation of sex at disaster sites and in corroborating reports from scientists. This study evaluated calcaneal angles of Kwara populace and estimated sex using X‑ray (Bohler’s angle [BA], crucial angle of Gissane [CG], Fowler–Philips angle [FPA], calcaneal inclination angle [CIA], and calcaneal compression angle [CCA]). MATERIALS AND METHODS: One hundred and ten lateral radiographs consisting of 59 males and 51 females (unilateral) were used in this study. The study was carried out on randomly collected lateral calcaneal radiographs of adults in several hospitals in Kwara state. Standard anthropometric methods were used to measure the right and left calcaneal angles: BA, GA, FPA, CIA, and CCA. Data were analyzed using SPSS version 23 (IBM® Armonk, New York, USA) statistical software. Confidence level was set at 95% as P ≤ 0.05 was considered statistically significant. RESULTS: For right and left calcaneus in both sexes, the calcaneal angles were not significant. The P value was >0.05 (P > 0.05), indicating a nonstatistically significant values for the calcaneal angles. This present study, following measurements of calcaneal parameters in determining the sex of the right and left foot, showed no significant statistical difference across all five parameters. CONCLUSION: The findings showed that the measured calcaneal parameters cannot be used for determining sex.