Browsing by Author "Lawal, M."
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Item Artemether- Lumefantrine Mixed Ligand Complexes: Synthesis and In vitro Antiplasmodial activity Studies(Published by Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2018-12-25) Rajee, A. O.; Babamale, H. F.; Lawal, M.; Ayinla, S. O.; Lawal, A.; Obaleye, J. A.Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.Item Chelation, Characterization and Antimicrobial screening of Mixed Isoniazid - Vitamin C complexes(Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2017-05-04) Bamigboye, M. O.; Obaleye, J. A.; Lawal, A.; Babamale, H. F.; Ajibola, A. A.; Adimula, V. O.; Lawal, M.In this study, mixed Zn(II), Cu(II), Co(II) complexes of Isoniazid and vitamin C were synthesized and characterized by melting point, conductivity measurement, Fourier Transform Infra-red (FT-IR), Atomic Absorption Spectroscopy and elemental analyses. The bonding nature of the mixed parent ligands and the structure of the complexes were based on analytical and spectroscopic techniques. The complexes were proposed to have the formula [M1L1L2(Cl2)], [M2L1L2(SO4)], [M3L1L2(Cl2)] where M1 = Zn(II), M2 = Cu(II), M3= Co (II) L1= Isoniazid and L2 = Vitamin C. The infra-red data relate to the results of the most informative and indicative region. The result of spectra data confirmed that the two ligands were bidentate in their mode of coordination with the metal ions. The complexes are in octahedral geometry and the molar conductance was found to be non-electrolytic in nature. Antimicrobial test was carried out against four bacterial species namely Bacillus subtilus, Staphylococuss aureus, Escherichia coli and Pseudomonas aeroginosa. All the complexes showed higher antibacterial activity at the same concentration against the microorganisms used compared to the ligandsItem Preparation, Characterization and Biological Studies of Metal Complexes of Mixed Ligands of Nicotinamide and Metronidazole(Nigerian Society of Biochemistry and Molecular Biology, 2017-10-25) Lawal, A.; Ayanwale, P. A.; Rajee, A. O,; Bamigboye, M. O,; Saadu, H. O.; Lawal, M.; Babamale, H. F.; Nnabuike, G. G.; Yunus Issa, M. T.; Amolegbe, S. A.The Mn2+, Fe2+, Cu2+, Co2+, Zn2+ and Ni2+ complexes of mixed nicotinamide and metronidazole were prepared and characterized using solubility, melting point, conductivity measurement, CHNO (carbon, hydrogen, nitrogen, oxygen) elemental analysis, powder X-ray diffraction and infrared spectroscopy . The results of the physical and spectroscopic data confirm the formation of the complexes. For nicotinamide, coordination of the metal to the ligands occurred through the nitrogen of the pyrimidine group, while for mertonidazole, coordination took place through the nitrogen of the amine group. The antibacterial activity of the complexes was carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella spp, Escherichia coli and Candida spp. Only Cu(II) mixed complex had high inhibitory activity against all three bacteria species. The results of antifungal activity show that all the complexes have no inhibitory activity against the two fungi species compared with the corresponding ligandsItem Solvent Free Synthesis, Characterization and Antibacterial Studies of Urea and Thiourea Metal Complexes(Faculty of Pure and Applied Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria, 2016-10-25) Lawal, A.; Nnabuike, G. G.; Obaleye, J. A.; Bamigboye, M. O.; Lawal, M.Solvent-based synthesis as well as Liquid Assisted Grinding (LAG) synthesis of urea and thiourea complexes is described for comparison purposes. The resulting complexes of both methods of syntheses were characterized using melting points, conductivity values, spectroscopic data (IR, UV-Visible) and antibacterial activity study. Spectral data of the complexes synthesized by LAG method was found to be similar to those synthesized by conventional synthesis. All the ligands were found to be monodentate and all the complexes exhibited tetrahedral and square-planar geometry. The LAG method was carried out by introducing a few drops of solvent. The method is faster with a better yield compared to solvent- based method. The antimicrobial study of the ligands and the complexes was carried out against Gram-positive (Staphylococus aureus and Bacilius subtilis) and Gram-negative bacteria (Eschericia. coli). The antibacterial activity study of the complexes showed that they possessed higher inhibitory activity than their parent ligands at concentration of 200 μgml-1.