Browsing by Author "Lawal Abubakar Zubair"

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    Antihypertensive Potential of Azadirachta indica Methanolic Leaf Extract in Salt-induced Hypertensive Rat Model
    (Anatomical Society of Nigeria, 2025-02-09) Lawal Abubakar Zubair; Ibrahim Munirudeen; Oluseyi Omotayo Divine; Olalekan Salaudeen Fatai; Saka Saheed Olanrewaju; Aina Kareem Mutiat; Olorukooba Halima Omolara; Oludele Oriire; Abdulraheem Hamzat; David Kehinde Busuyi; Folorunso Kolade Pelumi Idunnuoluwa; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa
    Hypertension is a condition arising from persistently elevated blood pressure, leading to severe complications, including death. Factors such as high salt consumption and family history predispose individuals to hypertension. Azadirachta indica (AI) has shown potential in reducing high blood pressure, irregular heart rhythms, and abnormal heartbeats. This study aimed to assess the antihypertensive effect of Azadirachta indica methanolic leaf extract (AIMLE) on salt-induced hypertension in albino rats. The study involved 25 healthy male albino rats (150 - 250g), divided into five groups (A-E, n=5). Group A received normal salt feed and water (vehicle), group B received high-salt feed (HSF), group C received HSF and 500 mg/kg AIMLE, group D received HSF and 1000 mg/kg AIMLE, and group E received HSF and 10 mg/kg Nifedipine. Systolic (SBP) and diastolic (DBP) blood pressures were measured using the tail cuff method. Antidiuretic hormone (ADH) and Angiotensin-Converting Enzyme (ACE) levels were analyzed using ELISA methods. Nitric Oxide, Potassium, Bicarbonate, and Sodium were assayed using the colorimetric method. Administration of HSF caused a significant (p <0.05) progressive increase in SBP and DBP after 8 weeks when compared with the normal control. However, treatment with the serial doses of AIMLE resulted in a significant (p <0.05) dose dependent decrease in SBP, DBP and serum nitric oxide concentrations as well as decrease in serum levels of ACE, ADH, potassium, bicarbonate, and sodium ions when compared with untreated HSF group, after 8 weeks. These findings suggest that Azadirachta indica leaf extract may offer a natural remedy for managing hypertension.
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    Depressive State Assessment of Pregnant Women Attending the Antenatal Clinic of University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria
    (Anatomical Society of Nigeria, 2025-02-09) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Gwadabe Sadiyah Musa; Jimoh Olanrewaju Saheed; Bello Sultan Adeola; Onwunali Maryprecious Nwakaego; Adeojo Ayomide Simidele; Gabriel Opeyemi Janet; Bamishe Gideon Adedotun; Alabi Miracle Tosin; Afolayan, Joshua Adeyinka; Abubakr Maimunat Kewukunmi; Okunnu Boluwatito Emmanuel; Isah Aaliyah Oiza; Lawal Abubakar Zubair; Lawal Rafiat Oluwatosin; Ayinla Maryam Tayo; Ojulari Lekan Sheriff
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS-16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.