Browsing by Author "Kola-Mustapha Adeola T."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Evaluation of Zingiber officinale Rosc. and Ocimum basilicum L. Essential Oils-Loaded Gel Base for the Treatment of Oral Candidiasis(Tropical Journal of Natural Product Research, 2020-10) Kola-Mustapha Adeola T.; Jaiyeola E. T.; Olufadi-Ahmed H. Y.; Ayotunde H. T.; Ghazali Y. O.Oral candidiasis is an opportunistic infection that affects the oral cavity and could worsen the severity of an underlying disease. This research is focused on the formulation of an oral herbal gel from essential oils of Zingiber officinale Rosc. (ZO) and Ocimum basilicum L. (OB) for the potential use in the management of oral candidiasis. Antifungal activities of the oil extracts were evaluated against ten clinical isolates of Candida albicans using the agar well diffusion method and measurement of minimum inhibitory/fungicidal concentration (MIC/MFC). The oils were tested individually and subsequently combined at predetermined ratios. The oils were formulated into carbopol-based gels, the antifungal activity and physico-chemical properties of the gels were assessed. Nystatin was used as a positive control. Sensitivity test showed that Candida albicans isolates were sensitive to each of the essential oil extracts at a concentration of 10%v/v. The essential oil extracts combination of 25:75 (ZO:OB) yielded the highest zones of inhibition which ranged from 28.00 ± 0.65 to 39.00 ± 1.45 mm. The results were higher than that obtained for the nystatin control (26.00 ± 1.20 to 30.00 ± 1.05 mm). Five batches of gels incorporated with the essential oils exhibited good physicochemical characteristics. However, the herbal gels exhibited lower antifungal activity than the essential oils against Candida albicans isolates. These outcomes demonstrate the antifungal activity of the herbal gels and thus its potential for use in the management of oral candidiasis.Item The COVID-19 response in Nigeria: Adequate protection of a fragile healthcare delivery system.(The Nigerian Journal of Pharmacy, 2021-03-31) Kola-Mustapha Adeola T.; Ubani-Ukoma, U; Ilomuanya, M.O; Nnamani, P.O.The COVID-19 pandemic has impacted the healthcare system in Nigeria. The response of the government has been one that places the health and well-being of the people at its highest priority. This was evidenced by the instituted lockdown of the country soon after the first cases emerged. Specific information on appropriate hygiene, safety, and security was provided through the Nigeria Centre for Disease Control (NCDC) and several health-based organizations. This provided a clear direction on what actions the citizens should take when they start to feel ill especially if they showed the classic symptoms of the disease. Reviewing and implementing new human resource policies in response to these changing circumstances and regulations is continually required. Continuous monitoring of the COVID-19 situation and understanding what guidance is being offered will be essential to the crisis management leadership team (task force) dedicated to leading the effort in Nigeria