Browsing by Author "Kola-Mustapha Adeola T"
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Item An Evaluation of the Impact of Zinc and Copper Metal-Organic Frameworks (MOFs) on the Drug Release Profiles of Piroxicam(Journal of Pharmaceutical Research, Development and Practice, 2020-06) Kola-Mustapha Adeola T; Ayuba, Aisha A.; Amali, M.O; Atunwa S.A.; Ishola F.; Tella A.C.Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) poorly soluble in an aqueous medium with a slow and gradual dissolution in biological fluids resulting in sub-optimal efficacy in patients. In recent times, Metal-Organic Frameworks (MOFs), a new class of highly tenable hybrid porous materials with unique properties have been explored for usage as drug carriers and other biomedical applications. This study is aimed at studying the solubility, in vitro release profile and kinetics of piroxicam loaded Zinc and Copper Metal-Organic Frameworks. Piroxicam was loaded on Zinc and Copper MOFs and tested for its solubility, dissolution and drug release profile. The mechanisms of the release pattern of the drug from Zinc and Copper MOFs were analysed using kinetic models. At the end of the study, Piroxicam-loaded Zn MOFs had solubility of 161.34 ± 0.63 μg/mL, while that of Cu MOFs and pure piroxicam had solubility of 154.31 ± 1.27 μg/mL and 134.86 ± 0.48 μg/mL respectively. Within a period of 24 hours, Piroxicam had the highest release from Zn MOFs; with a drug release in the range of 43.70 to 99.10%. Piroxicam was released from the loaded Cu MOFs in the range of 41.20 to 78.3% while the release of pure Piroxicam was in the range of 37.50 to 49.0%. Mechanism of piroxicam release was by Fickian diffusion. Piroxicam was successfully loaded on Zinc and Copper MOFs. Zn MOFs demonstrated a better solubility and dissolution profile as compared to Cu MOFs. These study shows the drug delivery potentials of the Zinc and Copper MOFs in improving the solubility and drug release of piroxicam.Item Synergistic effect of polymer-drug self-assembly and hydrotropic complexation on the delivery of ibuprofen(Journal of Pharmaceutical Research, Development and Practice,, 2018-05) Kola-Mustapha Adeola T; Abioye Amos O.Drug-loaded polymeric nanoconjugate is a valuable drug delivery strategy to enhance the effectiveness of poorly soluble drugs. This study investigates the synergistic effect of polymer-drug self-assembly and hydrotropic complexation, on conjugation efficiency and in vitro dissolution kinetics of ibuprofen. Ternary Ibuprofen-DEAE-Dextran-Nicotinamide nanoconjugates were prepared by hydrotropic solubilization and characterized via particle size measurement, zeta potential, conjugation efficiency, Scanning Electron Microscopy (SEM), Fourier Transform InfraRed (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), dissolution and drug release kinetics. The formulation of ibuprofen-DEAE-Dextran conjugate reduced the size of ibuprofen (2.87 μm) significantly to 77.92 nm (272-fold) at 0.1% (2.0 x 10-3 mM) DEAE-Dextran concentration. The zeta potential values were relatively low (1.24 to +13.87 mV) indicating low repulsion stabilization. Conjugation efficiency increased to a maximum of 95.68% and particle size of nanoconjugates was in the range 77.92 ± 1.61 to 994.27 ± 91.85 nm. The surface morphologies were spherical. FTIR revealed the formation of an amide via electrostatic, hydrophobic and hydrogen bonding interaction between solubilized ibuprofen and the cationic polymer, DEAE-Dextran. DSC analysis showed that the nanoconjugates exhibited new broad and diffuse peaks. The TGA thermograms exhibited two steps degradation profile. Marked enhancement of drug release was achieved by this method. The mechanism of release was non-Fickian diffusion for lower concentrations of DEAE-Dextran, while super case II was exhibited by higher concentrations. This work shows the formulation of amorphous ibuprofen-DEAE-Dextran nanoconjugates via a combination of polymer-drug self-assembly and hydrotropic solubilization with the potential of improving the delivery of poorly soluble ibuprofen.