Browsing by Author "Kayode, Ezekiel Adewole"
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Item Antimalarial plants with potential male-factor antifertility properties(De Gruyter, 2019-09-17) Kayode, Ezekiel Adewole; Alfred, Francis AttahMalaria, caused mainly by Plasmodium falciparum among other Plasmodium species, is one of the main causes of death from parasitic diseases. Malaria is still a health problem mainly because of the cost of effective antimalarial drugs and the growing parasite resistance to conventional antimalarial drugs, making a great proportion of the people in malaria endemic countries dependent on plants for its treatment. Corollary, a large number of the rural populations consume antimalarial herbal preparations in large or excessive quantities despite the fact that it has been reported that some of them could cause male-factor infertility, a growing global health concern. Few studies have compiled information on the scientifically validated male-factor antifertility effects of these antimalarial plant remedies. The aim of this review therefore is to compile information on commonly used antimalarial plant remedies that have been experimentally validated as having male-factor antifertility effects. Thus, antimalarial plant remedies with experimentally confirmed male-factor antifertility potentials and compounds isolated from them are identified and discussed. The male-factor antifertility effects of these plants include reduction of sperm quality, regulation of reproductive hormone levels and induction of lipid peroxidation. Indiscriminate use of such antimalarial plants is discouraged when male contraception is not desired.Item Exploring phytotherapeutic approach in the management of valproic acid-induced toxicity(Online: Advances in Traditional Medicine, 2021-05-26) Kayode, Ezekiel Adewole; Alfred, Francis Attah; Sharon, Oluchi OsaweThe antiepileptic drug, valproic acid (VPA), also used for treating psychiatric disorders, is hampered by its toxicity. Its associated adverse effects include hepatotoxicity, nephrotoxicity, central nervous system (CNS) depression, respiratory failure, acute pancreatitis, thrombocytopenia, hyperammonaemia, bone marrow suppression, and teratogenicity. Currently, no antidotes exist for treating VPA toxicity and therapeutic management is majorly supportive while modifying drug disposition. The lack of effective treatment has prompted evaluating plant-derived products to manage this challenge since studies show their protective potential against drug-induced toxicities. This review investigates purported mechanisms and the protective capacity of plants products against VPA-induced toxicity. The compiled studies revealed that VPA causes hepatotoxicity, nephrotoxicity, ocular toxicity, teratogenicity and reproductive toxicity among others. Further findings highlighted the oxido-inflammatory and apoptotic pathway as crucial mechanisms of VPA-induced organ toxicities. Extracts of Apium graveolens L., Bacopa monniera, Green tea, Kaempferia parviflora, Korean red ginseng, Ocimum sanctum, Oryza sativa, Withania somnifera and plant-derived compounds, including diammonium glycyrrhizinate, sulforaphane, vitamin U, B6, E, diallyl trisulfide, curcumin, α-tocopherol, quercetin, piperine, resveratrol, hesperitin, thymoquinone, caffeic acid and asiatic acid exhibited protection against VPA-induced toxicities. From these observations, it is suggested that further studies should target evaluating more plant products as well as identifying and isolating specific compounds from such, and others demonstrating protective effect against toxicities induced by VPA.