Browsing by Author "Kadir, RE"

Now showing 1 - 2 of 2
  • Item
    Low glycaemic Index foods, a better option for pre-exercise meals
    (ANNALS OF MEDICAL RESEARCH, 2017) Ojulari, Sherif Lekan; Ayinde, Taofeeq O; Kadir, RE; Biliaminu, SA; Nafiu, AB; Ayinla, Maryam Tayo; Abdulazeez, FI; Jimoh-Abdulghaffaar, HO; Imam-Fulani, Aminat Omolola; Fatai, RA
  • Item
    Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats.
    (Research Journal of Health Sciences,, 2018) Omotoso, Gabriel Olaiya; Lewu, SF; Kadir, RE; Adunmo, GO; Ameen, MO
    Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats G.O. Omotoso, R.E. Kadir, S.F. Lewu, I.T. Gbadamosi, A.A. Akinlolu, G.O. Adunmo, R.M. Kolo, M.O. Lawal, M.O. Ameen Abstract Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.