Browsing by Author "Jimoh-Abdulghaffaar Hidaayah Oluwamayowa"

Now showing 1 - 8 of 8
  • Item
    Anti-depressant Potentials of Some Bioactive Components of Basella alba Leaves in Chronic Unpredictable Stress Rat Model
    (Nigerian Journal of Neuroscience, 2023-04-20) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Areola Emmanuel Damilare; Jimoh Olanrewaju Saheed; Sodimu Ayobami Tobi; Adebosin Victor Tope; Bakare Azeez Olawale; Ipinmoroti Deborah Ifeoluwa; Olagbemi Oluwafisolami; Yousuph Sarah Olanike; Egwa Jessica Okache; Ojulari Lekan Sheriff
    Bioactive components of Basella alba leaves are responsible for their antidepressant-like activity. However, the component with the greatest anti-depressant activity is unknown. This study investigated the antidepressant-like activities of the bioactive components (phenols, flavonoids, and glycosides) in Basella alba leaves. Forty-two male Wistar rats weighing 50–200 g were randomly divided into six groups (n=7). All the groups, except for the control, were subjected to chronic unpredictable stress (CUS) for five weeks. The rats in the CUS groups were treated with normal saline (1 mL/kg), escitalopram (5 mg/kg), and each of the phenol-, flavonoid-, and glycoside-rich Basella alba extracts (200 mg/kg) orally for twenty-one days. The tail suspension, sucrose preference, light-dark box, and hole-board tests were carried out before and after the induction of depression. In the CUS groups, reduced mobility time on tail suspension, increased percentage sucrose consumption, frequency of head dips on the hole board, and line-cross frequency in the light-dark box were observed. The latency on the hole board was reduced with Basella alba components, while there was a significant (p<0.05) decrease in serum brain-derived neurotrophic factor and an increase in serum IL-6 in the CUS animals not treated with extracts. The phenol-rich Basella alba extract showed the most potent antidepressantlike activity, followed by the flavonoid-rich extract. The bioactive components of Basella alba, particularly phenols, were effective in ameliorating the depressive features of CUS and should be further studied for use as an adjunct or standalone antidepressant.
  • Item
    Antihypertensive Potential of Azadirachta indica Methanolic Leaf Extract in Salt-induced Hypertensive Rat Model
    (Anatomical Society of Nigeria, 2025-02-09) Lawal Abubakar Zubair; Ibrahim Munirudeen; Oluseyi Omotayo Divine; Olalekan Salaudeen Fatai; Saka Saheed Olanrewaju; Aina Kareem Mutiat; Olorukooba Halima Omolara; Oludele Oriire; Abdulraheem Hamzat; David Kehinde Busuyi; Folorunso Kolade Pelumi Idunnuoluwa; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa
    Hypertension is a condition arising from persistently elevated blood pressure, leading to severe complications, including death. Factors such as high salt consumption and family history predispose individuals to hypertension. Azadirachta indica (AI) has shown potential in reducing high blood pressure, irregular heart rhythms, and abnormal heartbeats. This study aimed to assess the antihypertensive effect of Azadirachta indica methanolic leaf extract (AIMLE) on salt-induced hypertension in albino rats. The study involved 25 healthy male albino rats (150 - 250g), divided into five groups (A-E, n=5). Group A received normal salt feed and water (vehicle), group B received high-salt feed (HSF), group C received HSF and 500 mg/kg AIMLE, group D received HSF and 1000 mg/kg AIMLE, and group E received HSF and 10 mg/kg Nifedipine. Systolic (SBP) and diastolic (DBP) blood pressures were measured using the tail cuff method. Antidiuretic hormone (ADH) and Angiotensin-Converting Enzyme (ACE) levels were analyzed using ELISA methods. Nitric Oxide, Potassium, Bicarbonate, and Sodium were assayed using the colorimetric method. Administration of HSF caused a significant (p <0.05) progressive increase in SBP and DBP after 8 weeks when compared with the normal control. However, treatment with the serial doses of AIMLE resulted in a significant (p <0.05) dose dependent decrease in SBP, DBP and serum nitric oxide concentrations as well as decrease in serum levels of ACE, ADH, potassium, bicarbonate, and sodium ions when compared with untreated HSF group, after 8 weeks. These findings suggest that Azadirachta indica leaf extract may offer a natural remedy for managing hypertension.
  • Item
    Assisted Reproductive Technology: The Perspectives of Religious Leaders in Ogun State, South-Western Nigeria
    (Wolters-Kluwer (MedKnow), 2023-09-06) Jimoh Olanrewaju Saheed; Ahmed AbdulMumin K.; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adeniyi Makinde A.; Egua Andrew I.; Animashaun Oladimeji A.; Gwadabe Sadiya M.; Ahmed Abdullahi
    Background: Infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Prevalence is about 30.3% in Africa. In Nigeria, it is associated with emotional crises and stigmatization. Consequently, couples seek orthodox and non-orthodox treatment including assisted reproductive technology (ART) to achieve conception. ARTs have helped with about 50% of infertility cases in the Western world. However, it is yet to achieve the same feat in Africa and this has been attributed to religious hindrances among other factors. The study aims to assess the awareness, knowledge, and beliefs of religious leaders on ART. Materials and Methods: A descriptive cross-sectional study using questionnaires was carried out among randomly selected religious leaders above the age of 18 years using a multistage sampling technique. Data from the questionnaires were analyzed using SPSS version 22.0. Level of statistical significance was set at P < 0.05. Results: The results showed that 77.7% agreed ART is used to manage infertility, 88.2% agreed that ART can sometimes fail, and 92.3% believed their faith permits ART. All the religious platforms accepted ART. The male respondents agreed to accept adults born through ART to lead prayers in churches, mosques, and traditional settings unlike their female counterparts. Conclusion: Majority of followers of Christianity, Islam, and traditional religions are aware of, and accept some, but not all ARTs, and will accept children born through ART into their congregations.
  • Item
    Atherogenic and Cardiovascular Risks of Women on Combined Oral Contraceptives: A Comparative Study
    (Wolters-Kluwer (MedKnow)., 2021-12) Jimoh Olanrewaju Saheed; Abdul Ishaq Funsho; Balogun Olayinka R; Biliaminu Sikiru A; Adeniran AS; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adesina Kikelomo T; Ahmed Abdullahi; Oladosu Wahab Olatunbosun
    Although combined oral contraceptive (COC) is commonly used in sub‑Saharan Africa, data on its cardiovascular disease risk remains scanty. The study aimed to determine serial serum lipid profiles and cardiovascular disease risks among COC‑users. Methods: This is a prospective, comparative multicentered study conducted at four health facilities in Nigeria. Participants were new users of contraceptives; 120 each of women initiating COCs (group I) and those initiating other forms of nonhormonal contraceptives (group II) were recruited and monitored over a 6‑month period. Serial lipid profile, blood pressure, and atherogenic risk for cardiovascular diseases were measured at recruitment (start) and scheduled follow‑up clinic visits at 3 months and 6 months for all participants. Statistical analysis was performed with SPSS (version 21.0) and P value < 0.05 was considered significant. Results: In all, 225 participants (111 COC‑users, 114 nonCOC‑users) that completed the study were aged 18 to 49 years. There was a statistically significant increase in the diastolic blood pressure (P = 0.001), Low Density Lipoprotein‑ Cholesterol (P = 0.038) and higher atherogenic risk (P = 0.001) among COC‑users compared to nonCOC‑users. The serial total serum cholesterol, triglyceride, High Density Lipoprotein, systolic blood pressure, and body mass index were higher among COC‑users but were not statistically significant compared to nonCOC‑users. Conclusion: Alterations in lipid profile and increased short‑term atherogenic risk for cardiovascular disease were reported among the COC‑users in this study. Serial lipid profile and atherogenic risk assessment for cardiovascular diseases are recommended for monitoring of COC‑users.
  • Item
    Depressive State Assessment of Pregnant Women Attending the Antenatal Clinic of University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria
    (Anatomical Society of Nigeria, 2025-02-09) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Gwadabe Sadiyah Musa; Jimoh Olanrewaju Saheed; Bello Sultan Adeola; Onwunali Maryprecious Nwakaego; Adeojo Ayomide Simidele; Gabriel Opeyemi Janet; Bamishe Gideon Adedotun; Alabi Miracle Tosin; Afolayan, Joshua Adeyinka; Abubakr Maimunat Kewukunmi; Okunnu Boluwatito Emmanuel; Isah Aaliyah Oiza; Lawal Abubakar Zubair; Lawal Rafiat Oluwatosin; Ayinla Maryam Tayo; Ojulari Lekan Sheriff
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS-16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.
  • Item
    Favourable pregnancy outcome following gliclazide use throughout pregnancy in diabetic female Sprague-Dawley rats
    (Lagos State University College of Medicine, 2018) Ojulari Lekan Sheriff; Kadir Risikat Eniola; Abdulazeez Fatima I.; Ayinde Olarewaju Toafeek; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adegoke Olufeyisipe A.
    Objectives: The incidence of diabetes mellitus (DM) is associated with complications with reproduction. The effect of gliclazide on pregnancy hormones and fetal outcomes in diabetic female rats was determined in this study. Methods: There were four experimental groups (control, diabetic control, gliclazide-treated and diabetictreated) of 20 rats each. Studies were carried out on days 7, 14, 19 and at term, to ascertain implantation, gestation, fetal outcome and measurement of some plasma hormone levels. Values represent mean ± SD and were analyzed by two-tailed ANOVA followed by a Post-hoc test. Differences were considered significant at p<0.05. Results: There were increases inplasma estradiol in the gliclazide-treated non-diabetic [day 14 (55.80±1.0; p=0.01), day 19 (55.80±3.1;p=0.02)] and diabetic [day 14 (25.42±1.7); p=0.03] groups, and also in plasma progesterone in the treated diabetic group [day 14 (35.12±6.2) p=0.02] only. Plasma corticosterone and plasma CRP decreased in the gliclazide-treated [corticosterone day 14 (356.30±24.1) p=0.01; day 19 (308.30±17.6) p=0.01]; [CRP day 14 (0.13±0.05) p=0.01] and the diabetic-treated [corticosterone day 14 (400.50±21.5) p=0.01, day 19 (424.10±22.4) p=0.01; [CRP day 14 (0.14±0.13) p=0.01] groups. There were no significant changes in the plasma levels of β-hCG and no abnormalities were observed in litters from all groups. Conclusion: Gliclazide improved some reproductive complications in the diabetic state and in the nondiabetic state. Consideration should be given to its use in managing reproductive complications associated with DM.
  • Item
    HONEY IMPROVES RADIOGRAPHIC FEATURES OF MONOSODIUM IODOACETATE-INDUCED STIFLE (KNEE) JOINT OSTEOARTHRITIS IN A RAT MODEL
    (2022-06) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Obalowu Abdulrauf M.; Aliyu Abdullahi; Jimoh Olanrewaju Saheed; Owoyele Bamidele Victor
    Osteoarthritis (OA) is the most common form of joint disease with over half of all people older than 65 years demonstrating radiographic changes of osteoarthritis in the knees. Honey is known to contain bioactive compounds that exert chondroprotective effects by counteracting the homeostatic dysregulation of the joint. However, its effect on the radiographic features of osteoarthritis has not been proven. This study was carried out to evaluate the effect of honey on radiographic features of monosodium iodoacetate (MIA)- induced knee osteoarthritis in female Wistar rats. Thirty female Wistar rats were randomly divided into five groups of six animals each. Animals in group one were healthy (control) rats, while animals in groups two to five were subjected to experimental osteoarthritis of the right knee joint induced by a single intra-articular injection of 1mg of MIA. The animals in groups two, three, four, and five were treated with normal saline (1ml/kg b. w.), arthocare (glucosamine/chondroitin sulfate 6.67/8.33mg/kg b. w.), low dose honey (250mg/kg b. w.) and high dose honey (1,000mg/kg b. w.) respectively. All treatments were administered orally once daily using an oral cannula for twenty-one days. All animals were subjected to radiographic assessment of the right knee joint before and after induction of OA, and after treatment. High and low-dose honey reversed the loss of joint space; sclerosis of the tibial plateau, medial, and lateral femoral condyles, when compared to the arthocare-treated and untreated groups. In conclusion, honey improved radiographic features of knee osteoarthritis in a rat model induced by monosodium iodoacetate.
  • Item
    Meeting Review on the ISN Neuroscience School, Ondo 2024 Themed: “Gene-Environment Interactions in NeurologicalDisorders: A Contemporary Update”
    (Company of Biologists, 2025-04-21) Anadu Victor Ebube; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Gilbert Taidinda Tashara; Aneke Oluoma Vivian; Arietarhire Leviticus Oghenevurinrin; Chukwuyenum Patrick Ichipi-Ifukor; Abdullahi Abiodun Mohammed; Yadang Adeline Fanta; Oritsetimeyin Blessing Ugemuge; Oyerinde Toheeb Olalekan; Okah Leonard Sunday; Sulaimon Fatimo Ajoke; Gbayisomore Tolulope Judah; Olajide Tobiloba Samuel; Oyeniran David Anuoluwapo; Omotosho Omolabake Ifeoluwa; Oria Rademene; Ijomone Olayemi Kafilat
    Short summer courses focusing on the nervous system, mostly commonly called Neuroscience Schools are great venues for advancing training globally, particularly in low-middle income countries (LMICs). The ISN Neuroscience School, Ondo 2024, like other such neuroscience schools across the globe, attracted graduate students, postdoctoral fellows, early career researchers, and seasoned neuroscientists. The school was sponsored by the International Society for Neurochemistry (ISN) with additional support from the Company of Biologists (CoB). The school, which was held between August 11th and 16th, 2024 at the University of Medical Science, Ondo, Nigeria had the theme “Contemporary Update on Gene-Environment Interactions in Neurological Disorders”. Leading authorities in the field gave a series of talks during the event, summarizing the most recent findings on how environmental variables and genetic predispositions interact to affect the development and course of neurological illnesses. Through hands-on activities during practical sessions, participants gained a deeper knowledge of the approaches used to examine these interactions. Student pitches also promoted multidisciplinary cooperation and critical thinking by showcasing creative concepts and research ideas. The study of gene-environment interactions has several implications for the diagnosis, treatment, and prevention of neurological disorders. In this meeting report, we summarize and discuss relevance of the school’s activities while also highlighting prospects in this field in the African region. All in all, the occasion provided a lively forum for information sharing.