Browsing by Author "Jimoh-Abdulghaffaar, H. O."

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    Haemoglobin has no influence on pain perception of undergraduate students in Ilorin, North-Central, Nigeria
    (African Science Publications, 2024-10-21) Jimoh-Abdulghaffaar, H. O.; Olaniyan, O. E.; Jimoh, O. S.; Ananias, E. N.; Owoyele, B. V.
    Pain perception is influenced by various factors, including genetics, awareness, age, gender, and environmental factors (Hussain and Karim, 2019). This study aimed to determine if hemoglobin genotype variability affects human perception of pain. 208 participants aged 17-45 years from the University of Ilorin were recruited using purposive sampling. The participants were counselled and verbal consent was gotten from them before the procedure. Pain threshold and tolerance were assessed using the cold pressor test. 5mls of blood was drawn from antecubital vein and stored in Ethylenediamine tetraacetic acid (EDTA) bottles at 2⁰-6⁰C until hemoglobin electrophoresis was carried out. Data were analyzed using SPSS version 28.0 and presented as mean ± SD, median IQR, frequency as well as percentages and p-value < 0.05 was considered statistically significant. Sociodemographic results showed that 2.4% of participants were older than 35 years, 97.6% are unmarried and 85.6% are Yoruba. Hemoglobin electrophoresis revealed that 64% of participants were HbAA, 28.8% HbAS, 4.8% HbSS, and 2.4% HbAC. No significant variation was found in pain threshold between genotypes, though participants with the HbAS genotype had the highest pain threshold and the lowest pain tolerance, this warrants further investigation in larger sample. Higher pain threshold and tolerance may be conferred by HbS and HbC characteristics.
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    Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf2 up-regulation
    (Elsevier, 2022-10-20) Akintoye, O. O.; Ajibare, A. J.; Folawiyo, M. A.; Jimoh-Abdulghaffaar, H. O.; Asuku, A.; Owolabi, G. A.; Babalola, K. T.
    Sodium benzoate (SB) is a commonly-used food preservative, with a controversial report to its neurologicalbenefit and toxicity. Zinc (Zn) is a trace element that plays a crucial role in memory, inflammation and oxidativestress . This study was to investigate the effect of SB on rat cognition and memory and the possible modulatoryeffect of Zn supplement. Twenty four male Wistar rats were divided into four groups of six animals each. Animalsin groups 1–4 were treated with normal saline 1 ml/kg, SB 200 mg/kg , zinc sulphate 10 ml/kg and SB 200 mg/kg+ zinc sulphate 10 ml/kg/day daily respectively for three weeks. After treatment, the animals were subjected todifferent behavioural tests, and then sacrificed. Their blood samples were collected for catalase(CAT), superoxidedismutase(SOD) and interleukin-1B(IL-1B) assay. Brain samples were also collected for nuclear factor-erythroid-related factor 2(Nrf2), and acetylcholinesterase (AchE) mRNA gene expression. The serum levels of CAT and SODwere (p < 0.0001; p < 0.0001) reduced in the SB only-treated group compared to the other groups. Nrf2 geneexpression was totally shut down in the SB only-treated group but, up-regulated in the Zn-treated groups(p < 0.0001). The serum level of IL-1B was higher in the SB only-treated group compared to the other groups. SB-treated group spent longer time in the close arm (p = <0.0001), shorter time in the open arm (p = <0.0001) andhad higher anxiety index (p = 0.0045) than the Zn-treated groups. Conclusively, Zinc improves memory deficit,has anxiolytic, anti-oxidant and anti-inflammatory properties.