Browsing by Author "Jimoh Olanrewaju Saheed"

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    Anti-depressant Potentials of Some Bioactive Components of Basella alba Leaves in Chronic Unpredictable Stress Rat Model
    (Nigerian Journal of Neuroscience, 2023-04-20) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Areola Emmanuel Damilare; Jimoh Olanrewaju Saheed; Sodimu Ayobami Tobi; Adebosin Victor Tope; Bakare Azeez Olawale; Ipinmoroti Deborah Ifeoluwa; Olagbemi Oluwafisolami; Yousuph Sarah Olanike; Egwa Jessica Okache; Ojulari Lekan Sheriff
    Bioactive components of Basella alba leaves are responsible for their antidepressant-like activity. However, the component with the greatest anti-depressant activity is unknown. This study investigated the antidepressant-like activities of the bioactive components (phenols, flavonoids, and glycosides) in Basella alba leaves. Forty-two male Wistar rats weighing 50–200 g were randomly divided into six groups (n=7). All the groups, except for the control, were subjected to chronic unpredictable stress (CUS) for five weeks. The rats in the CUS groups were treated with normal saline (1 mL/kg), escitalopram (5 mg/kg), and each of the phenol-, flavonoid-, and glycoside-rich Basella alba extracts (200 mg/kg) orally for twenty-one days. The tail suspension, sucrose preference, light-dark box, and hole-board tests were carried out before and after the induction of depression. In the CUS groups, reduced mobility time on tail suspension, increased percentage sucrose consumption, frequency of head dips on the hole board, and line-cross frequency in the light-dark box were observed. The latency on the hole board was reduced with Basella alba components, while there was a significant (p<0.05) decrease in serum brain-derived neurotrophic factor and an increase in serum IL-6 in the CUS animals not treated with extracts. The phenol-rich Basella alba extract showed the most potent antidepressantlike activity, followed by the flavonoid-rich extract. The bioactive components of Basella alba, particularly phenols, were effective in ameliorating the depressive features of CUS and should be further studied for use as an adjunct or standalone antidepressant.
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    Assisted Reproductive Technology: The Perspectives of Religious Leaders in Ogun State, South-Western Nigeria
    (Wolters-Kluwer (MedKnow), 2023-09-06) Jimoh Olanrewaju Saheed; Ahmed AbdulMumin K.; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adeniyi Makinde A.; Egua Andrew I.; Animashaun Oladimeji A.; Gwadabe Sadiya M.; Ahmed Abdullahi
    Background: Infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Prevalence is about 30.3% in Africa. In Nigeria, it is associated with emotional crises and stigmatization. Consequently, couples seek orthodox and non-orthodox treatment including assisted reproductive technology (ART) to achieve conception. ARTs have helped with about 50% of infertility cases in the Western world. However, it is yet to achieve the same feat in Africa and this has been attributed to religious hindrances among other factors. The study aims to assess the awareness, knowledge, and beliefs of religious leaders on ART. Materials and Methods: A descriptive cross-sectional study using questionnaires was carried out among randomly selected religious leaders above the age of 18 years using a multistage sampling technique. Data from the questionnaires were analyzed using SPSS version 22.0. Level of statistical significance was set at P < 0.05. Results: The results showed that 77.7% agreed ART is used to manage infertility, 88.2% agreed that ART can sometimes fail, and 92.3% believed their faith permits ART. All the religious platforms accepted ART. The male respondents agreed to accept adults born through ART to lead prayers in churches, mosques, and traditional settings unlike their female counterparts. Conclusion: Majority of followers of Christianity, Islam, and traditional religions are aware of, and accept some, but not all ARTs, and will accept children born through ART into their congregations.
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    Atherogenic and Cardiovascular Risks of Women on Combined Oral Contraceptives: A Comparative Study
    (Wolters-Kluwer (MedKnow)., 2021-12) Jimoh Olanrewaju Saheed; Abdul Ishaq Funsho; Balogun Olayinka R; Biliaminu Sikiru A; Adeniran AS; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adesina Kikelomo T; Ahmed Abdullahi; Oladosu Wahab Olatunbosun
    Although combined oral contraceptive (COC) is commonly used in sub‑Saharan Africa, data on its cardiovascular disease risk remains scanty. The study aimed to determine serial serum lipid profiles and cardiovascular disease risks among COC‑users. Methods: This is a prospective, comparative multicentered study conducted at four health facilities in Nigeria. Participants were new users of contraceptives; 120 each of women initiating COCs (group I) and those initiating other forms of nonhormonal contraceptives (group II) were recruited and monitored over a 6‑month period. Serial lipid profile, blood pressure, and atherogenic risk for cardiovascular diseases were measured at recruitment (start) and scheduled follow‑up clinic visits at 3 months and 6 months for all participants. Statistical analysis was performed with SPSS (version 21.0) and P value < 0.05 was considered significant. Results: In all, 225 participants (111 COC‑users, 114 nonCOC‑users) that completed the study were aged 18 to 49 years. There was a statistically significant increase in the diastolic blood pressure (P = 0.001), Low Density Lipoprotein‑ Cholesterol (P = 0.038) and higher atherogenic risk (P = 0.001) among COC‑users compared to nonCOC‑users. The serial total serum cholesterol, triglyceride, High Density Lipoprotein, systolic blood pressure, and body mass index were higher among COC‑users but were not statistically significant compared to nonCOC‑users. Conclusion: Alterations in lipid profile and increased short‑term atherogenic risk for cardiovascular disease were reported among the COC‑users in this study. Serial lipid profile and atherogenic risk assessment for cardiovascular diseases are recommended for monitoring of COC‑users.
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    Depressive State Assessment of Pregnant Women Attending the Antenatal Clinic of University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria
    (Anatomical Society of Nigeria, 2025-02-09) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Gwadabe Sadiyah Musa; Jimoh Olanrewaju Saheed; Bello Sultan Adeola; Onwunali Maryprecious Nwakaego; Adeojo Ayomide Simidele; Gabriel Opeyemi Janet; Bamishe Gideon Adedotun; Alabi Miracle Tosin; Afolayan, Joshua Adeyinka; Abubakr Maimunat Kewukunmi; Okunnu Boluwatito Emmanuel; Isah Aaliyah Oiza; Lawal Abubakar Zubair; Lawal Rafiat Oluwatosin; Ayinla Maryam Tayo; Ojulari Lekan Sheriff
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS-16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.
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    HONEY IMPROVES RADIOGRAPHIC FEATURES OF MONOSODIUM IODOACETATE-INDUCED STIFLE (KNEE) JOINT OSTEOARTHRITIS IN A RAT MODEL
    (2022-06) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Obalowu Abdulrauf M.; Aliyu Abdullahi; Jimoh Olanrewaju Saheed; Owoyele Bamidele Victor
    Osteoarthritis (OA) is the most common form of joint disease with over half of all people older than 65 years demonstrating radiographic changes of osteoarthritis in the knees. Honey is known to contain bioactive compounds that exert chondroprotective effects by counteracting the homeostatic dysregulation of the joint. However, its effect on the radiographic features of osteoarthritis has not been proven. This study was carried out to evaluate the effect of honey on radiographic features of monosodium iodoacetate (MIA)- induced knee osteoarthritis in female Wistar rats. Thirty female Wistar rats were randomly divided into five groups of six animals each. Animals in group one were healthy (control) rats, while animals in groups two to five were subjected to experimental osteoarthritis of the right knee joint induced by a single intra-articular injection of 1mg of MIA. The animals in groups two, three, four, and five were treated with normal saline (1ml/kg b. w.), arthocare (glucosamine/chondroitin sulfate 6.67/8.33mg/kg b. w.), low dose honey (250mg/kg b. w.) and high dose honey (1,000mg/kg b. w.) respectively. All treatments were administered orally once daily using an oral cannula for twenty-one days. All animals were subjected to radiographic assessment of the right knee joint before and after induction of OA, and after treatment. High and low-dose honey reversed the loss of joint space; sclerosis of the tibial plateau, medial, and lateral femoral condyles, when compared to the arthocare-treated and untreated groups. In conclusion, honey improved radiographic features of knee osteoarthritis in a rat model induced by monosodium iodoacetate.
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    Sex influences genetic susceptibility to depression-like behaviours in chronic unpredictable mild stress-exposed Wistar rats
    (Springer Nature, 2024-07-16) Jimoh‑Abdulghaffaar Hidaayah Oluwamayowa; Joel Ireoluwa Yinka; Jimoh Olanrewaju Saheed; Ganiyu Kaosara Oyinola; Alatiba Temidayo Micheal; Ogunyomi Victory Oluwaseyi; Adebayo Muhammed Salaudeen; Awoliyi Victoria Tolulope; Agaka Adamah Olamide; Oyedeji Aminat Bolatito; Kolade Ifeoluwa A.; Ojulari Lekan Sheriff
    Abstract Depression is one of the most common mood disorders among psychiatric diseases. It affects about 10% of the adult population. However, its etiopathogenesis remains poorly understood. Exploring the dynamics of stress-susceptibility and resilience will help in understanding the molecular and biological mechanisms underlying the etiopathogenesis of depression. This study aimed to determine the differences and/or similarities in factors responsible for susceptibility to depression-like behaviors in male and female Wistar rats subjected to chronic unpredictable mild stress (CUMS). Sixty Wistar rats (30 male and 30 female) weighing between 120 and 150 g were used for this study. The rats were divided into two sub-groups: control (10) and test (20) groups. Rats in the test groups were subjected to CUMS. Depression-like behaviors were assessed using light–dark box, sucrose preference, and tail suspension tests. Rats that showed depression-like behaviors following the behavioral tests (CUMS-susceptible group) were sacrificed, and their hippocampi were excised. Genomic deoxyribonucleic acid (gDNA) was purified from the hippocampal samples. Purified gDNA was subjected to whole genome sequencing (WGS). Base-calling of sequence reads from raw sequencing signal (FAST5) files was carried out, and variants were called from alignment BAM files. The corresponding VCF files generated from the variant calling experiment were filtered. Genes were identified, their impacts estimated, and variants annotated. Functional enrichment analysis was then carried out. Approximately 41% of the male and 49% of the female rats subjected to CUMS showed significant (p < 0.05) depression-like behaviors following assessment on behavioral tests. WGS of the hippocampal DNA revealed 289,839 single nucleotide polymorphisms variant types, 7002 insertions, and 34,459 deletions in males, and 1,570,186 single nucleotide polymorphisms variant types, 109,860 insertions, and 597,241 deletions in female Wistar rats. Three genes with high-impact variants were identified in male and 22 in female Wistar rats, respectively. In conclusion, female Wistar rats are more susceptible to depression-like behaviors after exposure to CUMS than males. They also have more gene variants (especially high-impact variants) than male Wistar rats.