Browsing by Author "Jimoh, O. S."

Now showing 1 - 6 of 6
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    Applicability of lipid ratios in the prediction of atherogenic risks of women on combined oral contraceptive pills in North-central Nigeria
    (Wolters-Kluwer (MedKnow), 2023-06-05) Jimoh, O. S.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Bakare, T. Y.; Popoola, G. O.; Oladosu, W. O.; Grillo, E. O.; Ahmed, A.; Adeniran, A. S.
    Background: Combined Oral Contraceptive (COC) pill is associated with atherogenic and cardiovascular changes. Some service providers use individual lipid parameters to assess these changes unlike objective calculation using standard formulae. Objective: To determine and compare the atherogenic changes in women on COCs using six lipid ratios; coronary heart disease risk ratio, atherogenic index of plasma, atherogenic co-efficient, Cholesterol index, Castelli risk index I, and Castelli risk index II. Materials and Methods: A prospective, comparative study among new acceptors of contraceptives at four family planning clinics in Ilorin, North-Central Nigeria. Participants were categorized into COCs acceptors (group I, n=120) and acceptors of non-hormonal contraceptives (group II, n=120). Participants were followed up with serial lipid profiles at 0, 3 and 6 months after uptake. Atherogenic risks were calculated using six standard formulae; statistical analysis was with SPSS version 21.0 and Analysis of variance (ANOVA) was used to compare the differences of more than two means, Bonferroni Post Hoc test was used to test for specific significance within the group and p-value <0.05 was considered significant. Results: A total of 225 participants (111 COC users, 114 non-COC users) aged 19 to 48 years completed the study. Serum levels of Low-Density Lipoprotein showed a statistically significant rise among the COC users over the study period (p=0.038), especially between the third and sixth months. The lipid ratios were statistically increased using all six methods despite apparently normal lipid parameters. Conclusion: Atherogenic changes may occur in the presence of apparently normal lipid parameters among COC users; therefore, serial lipid ratio using standard method formulae is recommended.
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    Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
    (Biomedical Communications Group, Ibadan, Nigeria, 2022-10) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Akintoye, O. O.; Ajibare, A. J.; Jimoh, O. S.; Owoyemi, J. O.; Ananias, E. N.; Ibiyeye, V. O.; Aboyeji, A. M.; Ojulari, L. S.
    Aqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (p˂0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
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    Evaluating the effects of heavy metals on seminal fluid antioxidant status and semen parameters among males with infertility at a tertiary centre in Nigeria
    (Karnavati University, 2024-11-15) Oladosu, W. O.; Lawani, O. A.; Oyewo, R. A.; Oderinu, K. A.; Jimoh, O. S.; Motayo, B. O.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    investigative tool of male infertility, has become necessary that focus should be on elucidating the aetiopathogenic causes of male fertility. This includes the impact of environmental toxic products such as levels of heavy metals that have been proposed to impact both the sperm quality and seminal antioxidant status. The study assessed how the seminal concentrations of specific heavy metals such as cadmium, lead and Iron affect the seminal fluid analysis (SFA) parameters and seminal antioxidant status of males exhibiting abnormal parameters of sperm, analysing infertile male patients consecutively in a cross‑sectional manner, with at least one abnormal SFA parameter, at a tertiary health centre. Materials and Methods: One hundred and thirty consenting males who have one or several anomalies with sperm characteristics were selected as subjects. Semen samples were collected, processed and centrifuged. The supernatants were analysed for the heavy metals using Buck Scientific 210/211VGP Flame Atomic Absorption Spectrophotometers 220GF Graphite Furnace and 220AS Autosampler and seminal Vitamins C and E, using spectrophotometric method and glutathione peroxidase, whereas catalase was analysed using ELISA method. Results: Subjects’ seminal levels of Cd, Fe and Pb were notably greater than those of controls, respectively. In addition, individuals’ levels of seminal antioxidants were noticeably lower than controls. Seminal antioxidant status and Seminal Cd, Fe and Pb were positive and negative significantly correlated with sperm count and active motility, respectively. Conclusion: Laboratory quantification of the seminal concentrations of these heavy metals in the evaluation of males with infertility, especially those still regarded as idiopathic, because of limitations of investigative tools and biomarkers, will be of clinical utility, in both the management and prevention of sperm quality deterioration
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    Ficus exasperata leaves aqueous extract influences pathophysiologic mechanisms of diabetic peripheral neuropathy in a rat model.
    (Open Science Publishers LLP, 2023-09-04) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ajibare, A. J.; Akintoye, O. O.; Jimoh, O. S.; Ananias, E. N.; Owoyemi, J. O.; Ibiyeye, V. O.; Ojulari, L. S.
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    Haemoglobin has no influence on pain perception of undergraduate students in Ilorin, North-Central, Nigeria
    (African Science Publications, 2024-10-21) Jimoh-Abdulghaffaar, H. O.; Olaniyan, O. E.; Jimoh, O. S.; Ananias, E. N.; Owoyele, B. V.
    Pain perception is influenced by various factors, including genetics, awareness, age, gender, and environmental factors (Hussain and Karim, 2019). This study aimed to determine if hemoglobin genotype variability affects human perception of pain. 208 participants aged 17-45 years from the University of Ilorin were recruited using purposive sampling. The participants were counselled and verbal consent was gotten from them before the procedure. Pain threshold and tolerance were assessed using the cold pressor test. 5mls of blood was drawn from antecubital vein and stored in Ethylenediamine tetraacetic acid (EDTA) bottles at 2⁰-6⁰C until hemoglobin electrophoresis was carried out. Data were analyzed using SPSS version 28.0 and presented as mean ± SD, median IQR, frequency as well as percentages and p-value < 0.05 was considered statistically significant. Sociodemographic results showed that 2.4% of participants were older than 35 years, 97.6% are unmarried and 85.6% are Yoruba. Hemoglobin electrophoresis revealed that 64% of participants were HbAA, 28.8% HbAS, 4.8% HbSS, and 2.4% HbAC. No significant variation was found in pain threshold between genotypes, though participants with the HbAS genotype had the highest pain threshold and the lowest pain tolerance, this warrants further investigation in larger sample. Higher pain threshold and tolerance may be conferred by HbS and HbC characteristics.
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    Patterns and predictors of contraceptive uptake among women attending family planning clinic in a tertiary health facility in South-west Nigeria: a 10-year review
    (Wolters-Kluwer-Medknow., 2024-04) Jimoh, O. S.; Vaughan, T. A.; Adebayo, M. A.; Ahmed, A. K.; Sule-Odu, I. O.; Badmaasi-Abdulraheem, T. M.; Lawal, B. O.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    Introduction: Contraception is a cost-effective way of reducing maternal morbidity and mortality in Sub-Saharan Africa, where its utilisation is still significantly low despite the alarming rate of unemployment and economic downturn. The choice and acceptability of different contraceptives depend on myriad factors. The study aimed to determine the patterns and predictors of contraceptive uptake among women attending a family planning clinic in a tertiary health facility in South-West Nigeria. Methods: This was a 10-year retrospective, descriptive study of the women who sought contraceptive services at the family planning clinic of Federal Medical Centre, Abeokuta, from 1 January 2011 to 31 December 2020. Relevant data were collected from the available records, coded, and analysed with the Statistical Package for Social Sciences (SPSS) version 25.0. Descriptive statistics were computed for all data, and the results were presented in tables and charts. Chi-square was used to test for significance, and a p-value < 0.05 was considered statistically significant. Results: A total number of 3,023 women accessed contraceptive services during the study period with clients between the ages of 17 and 56 years, and the highest percentage (36.3%) of contraceptive usage was between 30- 34 years, whereas 8.2% of women below the age of 25 years utilised contraceptive care services. The most common method of contraception used was implants, whereas the least common method was Bilateral Tubal Ligation (BTL). The relationship between age, parity, and level of education with the preferred methods of contraception was statistically significant (p=0.000). The lowest uptakes of contraception were recorded in 2011 and 2020. Information about contraception predominantly (71.6%) emanated from clinical personnel. Conclusion: The acceptability of different contraceptive methods is multifactorial, and the relevant stakeholders should be apprised of these critical determinants in policy formulation and implementation.