Browsing by Author "Imam A.,"

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    Morphometric Analysis of Sella Turcica in Nigerian Adult Cadaveric Dry and Wet Skulls
    (Department of Anatomy, Faculty of Basic Medical Sciences, 2025-06) Kareem S. B.,; Onigbolabi O. G.,; Imam A.,; Ibrahim A.,; Olawepo A,; Ajao M. S.
    Background and Aim: The sella turcica is a saddle-shaped area of bone in the middle cerebral fossa. This region's morphologic heterogeneity may be a sign of pathologic conditions before they show up clinically. The study aimed at comparing the dimensions of sella turcica in both dry and cadaveric skulls and determining the variability in its morphology using dry skulls. Methodology: Twenty-six (15 dry and 11 fresh cadaveric) adults males (16) and females (10) skulls identified as Nigerian by the University of Ilorin Teaching Hospital forensic pathologists, were used. The linear dimensions of the sella turcica were measured, and the shapes were traced out and compared. Social Statistical Package for Social Sciences version 20.0 and a glass prism were used to analyze the size of the sella turcica. Results: The linear measurements showed a statistically significant increase in the depth of the sella turcica of the wet skulls when compared to the dry skulls, but no statistically significant difference (p < 0.05) in other parameters. When the measurements were compared in both sexes, linear measurements had no statistically significant difference. The shapes of sella turcica in dry skulls were concave in 80% and irregular in 20%. Conclusion: Dry and wet skulls exhibited a notable difference in depth; the measurements of the sella turcica were comparable between both sexes. Using dry skulls, the shapes of sella turcica were concave in the majority. Its precise dimensions are helpful in the diagnosis, prognosis, and treatment of pituitary-related disorders.
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    Nigella Sativa Attenuates Trimethyltin-induced Histopathological Changes in Mice Hippocampi
    (ASSOCIATION OF SPECIALIST MEDICAL DOCTORS IN ACADEMICS (ASMeDA aka MEDSABAMS), 2022-06) Adana M.Y.,; Imam A.,; Kareem S.B.,; Ajao M.S.
    popular in agriculture and industry. Exposure to the compound is associated with several neurological symptoms which suggest neurotoxicity. The study was designed to investigate the antidotal effects of Nigella sativa (NS) on TMT-induced neurotoxicity on mice hippocamp. Materials and Methods: Seventy adult male mice weighing an average of 25g were randomly assigned into seven groups of ten animals each (Groups A- G). Animals in group A were administered single dose TMT (3mg/kg) and euthanized after 48 hours. Groups B, C, and D were given a single dose of TMT (3mg/kg), followed by a single weekly dose of NS (28ml/kg) for 1, 2, and 3 weeks respectively. Groups E, F, and G served as controls for trimethyltin (3mg/kg), Nigella sativa (28ml/kg), and saline (28ml/kg) respectively. NS. Results: The mice demonstrated tremors, aggressiveness and subtle seizures at the initial state in TMT administered groups with exophthalmos and pedal edema that subsides in the mice administered with TMT-NS. There were exudes of neuritic plaques, neurofibrillary tangles, and apoptotic cells on TMT-administered brains on histology. These observations were markedly reduced in the TMT-NS administered groups. Conclusion: The study concludes that the neurodestructive effects of TMT on the hippocampal neurons and its ability to negatively affect the neuro behavioral attitudes of the mice could be reversible following the administration of NS
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    Repeated acute oral exposure to Cannabis sativa impaired neurocognitive behavioural and corticohippocampal architectonics in wistar rats.
    (Physiological Society of Nigeria, 2016) Imam A.,; Ajao, M.S.,; Akinola, O.B.,; Ajibola, M.I.,; Ibrahim, A.,; Amin, A.,; Abdulmajeed, W.I.,; Lawal, Z.A.; Ali-Oluwafuyi, A.
    Summary: The most abused illicit drug in both the developing and the developed world is Cannabis disposing users to varying forms of personality disorders. However, the effects of cannabis on cortico-hippocampal architecture and cognitive behaviours still remain elusive. The present study investigated the neuro-cognitive implications of oral cannabis use in rats. Eighteen adult Wistar rats were randomly grouped to three. Saline was administered to the control rats, cannabis (20 mg/kg) to the experimental group I, while Scopolamine (1 mg/kg. ip) was administered to the last group as a standard measure for the cannabis induced cognitive impairment. All treatments lasted for seven consecutive days. Open Field Test (OFT) was used to assess locomotor activities, Elevated Plus Maze (EPM) for anxiety-like behaviour, and Y maze paradigm for spatial memory and data subjected to ANOVA and T test respectively. Thereafter, rats were sacrificed and brains removed for histopathological studies. Cannabis significantly reduced rearing frequencies in the OFT and EPM, and increased freezing period in the OFT. It also reduced percentage alternation similar to scopolamine in the Y maze, and these effects were coupled with alterations in the cortico-hippocampal neuronal architectures. These results point to the detrimental impacts of cannabis on cortico-hippocampal neuronal architecture and morphology, and consequently cognitive deficits.