Browsing by Author "Ibrahim Abdulmumin"

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    A Survey of knowledge and perception of surrogacy among health care providers in selected institutions in Ilorin
    (College of Health Sciences, University of Ilorin., 2025-04-05) Gwadabe Sadiya Musa; Olarinoye Adebunmi O; Omokanye Lukman Omotayo; Raji Hadijat Olaide; Adesina Kike Temini; Musa Muslimah Avushi; Ibrahim Abdulmumin; Abdulmussawri Oluwafuyi; Ijaiya Munidurdeen
    Background: Surrogacy is a type of Assisted Reproductive Technology (ART) whereby a third party carry a pregnancy on behalf of another couple, delivers a baby and hands the child to the commissioning parents at birth. Surrogacy is becoming increasingly popular in developed countries with a well-structured legislation and laws. However, surrogacy is a relatively new practice in Nigeria and no legislation are guiding any form of ART in Nigeria. This study aimed to assess the awareness, knowledge, perceptions and attitudes of health workers toward surrogacy. Materials and Methods: This was a cross-sectional survey of Health workers in University of Ilorin Teaching Hospital (UITH) and University of Ilorin Health Centre. A self administered questionnaire was used to obtain information on the knowledge of surrogacy, perception and attitudes toward surrogacy. Data was analysed using SPSS version 20. A total of 402 health workers of various categories participated in this study Results: Majority (85.5 %) of respondents had previous knowledge of surrogacy with the commonest source of information being the health facility (33.3%). Less than 20% of the respondents had previously seen a baby born through surrogacy. About two-thirds of respondents (66.7%) opined that the intended mother should be the legal mother of the child in full surrogacy, while 54 % supported the intended mother being the legal mother in partial surrogacy. Majority of respondents (79.4%) opined that the intended father should be the legal father of the child. Knowledge and awareness of surrogacy among the respondents was high. Conclusion/Recommendations: There is high level of awareness and knowledge of surrogacy among the respondents. The high level of knowledge and awareness did not reflect in the attitudes and perception toward surrogacy. There is also low acceptability of surrogacy as a means of assisted reproductive therapy among our respondents.
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    Dichlorvos Induced AChE Inhibition in Discrete Brain Regions and the Neuro-Cognitive Implications: Ameliorative Effect of Nigella Sativa
    (2018-05-13) Imam Aminu; Adebayo Muhammad; Abdulmajeed Wahab Imam; Alli-Oluwafuyi Abdulmusawir; Abdulbasit Amin; Ibrahim Abdulmumin; Gwadabe Sadiya; NiyiAbdulGafar Popoola
    Background: There has been a rise in accidental poisoning cases resulting from the indiscriminate use and exposure to Dichlorvos (DDVP), especially in developing countries, and no antidote with satisfactory efficacy is currently available. Thus, we investigated the AChE reactivation potential of Nigella sativa oil (NSO) following DDVP induced AChE inhibition patterns in the brain and the associated cognitive implications. Methods: Fourty Wistar rats were randomly divided into four groups of 10 each.; The controls were administered PBS (1 ml/kg); DDVP (8.8 mg/kg) was given to the experimental group I; while DDVP+NSO (8.8 mg/kg + 1 ml/kg) and NSO (1 ml/kg) was administered orally to the experimental groups II and III respectively. All treatments lasted for 14 consecutive days. Morris Water Maze (MWM) paradigm was used to assess the working memory, then rats were euthanized, the brain excised, three brains were fixed for histological examination (Nissl staining), and the other seven brains were homogenized for AChE activity and Ca2+ concentrations. Data were analyzed statistically, using ANOVA method and P values of ≤0.05 was considered as signi icant. Results: In this study, DDVP differentially inhibited AChE activities in various brain regions: cerebellum (86.1%), hippocampus (40.6%), frontal cortex (33.2%), medulla (21.5%), spinal cord (14.8%), and occipital cortex (8.9%). It reduced Ca2+ concentration, but had no effect on the delayed escape latency in the MWM, nor impaired the neuro architectures. NSO caused increased AChE activities, Ca2+ concentration and reduced escape latency, and improved histologic architectures. Conclusion: We concluded that NSO reactivated DDVP-induced AChE inhibition and improved memory indices, thus, it may serve as a potential treatment in the management of DDVP poisoning cases.