Browsing by Author "Hassan, S."

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    Phytochemical and Anti-Inflammatory Studies of Ethanol Extract of Terminalia macroptera Guill. & Perr. (Combretaceae) Stem Bark in Rats and Mice
    (Nigerian Journal of Pharmaceutical Research, 2017) salawu, Kayode; Usman, S. O; Agunu, Abdulkarim; Atuwa, Soliu; Hassan, S.
    Abstract Background: Terminalia macroptera Guill. & Perr. (Combretaceae) is a flowering plant used traditionally for the treatment of various disease conditions including hepatitis, dysentery, piles, edema, fever, gastritis, as aphrodisiac, applied to sprains and as a cleanser for washing sores. The aim of the work was to evaluate the qualitative and quantitative phytochemical properties and anti-inflammatory activity of the ethanol extract of T. macroptera stem bark. Material and Methods: Preliminary phytochemical screening and quantification was carried out on the extract using standard phytochemical methods. The ethanol stem bark extract was screened using the carrageenan induced rat paw edema model, and xylene induced edema model in mice at doses of 50, 100, 200, and 400 mg/kg doses orally. Lorke’s method was used to study the acute oral toxicity effect. Results: Preliminary phytochemical screening revealed the presence of flavonoids, tannins, terpenoids, saponins, and alkaloids. The total phenolic and flavonoid content of the extract were 164.8±10.37 (GAE/g of dried extract mg/g) and 193.6±6.37 (QE mg/g) respectively. The result showed that the extract produced a significant (p<0.05) dose independent inhibition with the maximum inhibition (89.93%) observed at 30 minutes at 50 mg/kg in the carrageenan induced edema and (49.5%) at 400 mg/kg in xylene induced models. No toxic effect was observed at 4.0g/kg of the extract in rats. Conclusion: The study showed that the ethanol stem bark extract is a good source of various phytochemicals that could be responsible for the observed anti-inflammatory activity of the plant.
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    Phytochemical and Anti-Inflammatory Studies of Ethanol Extract of Terminalia macroptera Guill. & Perr. Combretaceae) Stem Bark in Rats and Mice
    (Nigerian Journal of Pharmaceutical Research, 2017-12) Usman, S.; Agunu, A.; Atunwa, S.; Hassan, S.; Sowemimo, A.; Salawu, K.
    Background: Terminalia macroptera Guill. & Perr. (Combretaceae) is a flowering plant used traditionally for the treatment of various disease conditions including hepatitis, dysentery, piles, edema, fever, gastritis, as aphrodisiac, applied to sprains and as a cleanser for washing sores. The aim of the work was to evaluate the qualitative and quantitative phytochemical properties and anti-inflammatory activity of the ethanol extract of T. macroptera stem bark. Material and Methods: Preliminary phytochemical screening and quantification was carried out on the extract using standard phytochemical methods. The ethanol stem bark extract was screened using the carrageenan induced rat paw edema model, and xylene induced edema model in mice at doses of 50, 100, 200, and 400 mg/kg doses orally. Lorke’s method was used to study the acute oral toxicity effect. Results: Preliminary phytochemical screening revealed the presence of flavonoids, tannins, terpenoids, saponins, and alkaloids. The total phenolic and flavonoid content of the extract were 164.8±10.37 (GAE/g of dried extract mg/g) and 193.6±6.37 (QE mg/g) respectively. The result showed that the extract produced a significant (p<0.05) dose independent inhibition with the maximum inhibition (89.93%) observed at 30 minutes at 50 mg/kg in the carrageenan induced edema and (49.5%) at 400 mg/kg in xylene induced models. No toxic effect was observed at 4.0g/kg of the extract in rats. Conclusion: The study showed that the ethanol stem bark extract is a good source of various phytochemicals that could be responsible for the observed anti-inflammatory activity of the plant. Keywords: Terminalia macroptera, Anti-inflammatory, Phytochemical, Carrageenan
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    The Socioeconomic Burden of Family Caregivers of Patients with End-Stage Renal Disease in A Tertiary Hospital in North West, Nigeria: A Mixed Methods Study.
    (Al-Hikmah University, Ilorin: Al-Hikmah Journal of Health Sciences, 2023) Anyebe, E.E.; Lawal, H.; Isa, A.; Hassan, S.; Bello, R.E.
    Kidney diseases constitute one of the non-communicable diseases with significant global burden. Each year, about 1.7 million people die of kidney-related diseases. Chronic kidney diseases present a significant socio-economic and psychological burden for family members, especially the family caregivers. This study examined the social and economic burdens of family caregivers of patients with end-stage renal diseases, to bring to limelight the burden experienced by caregivers for possible interventions and the needed support. A mixed research method was adopted for the study. Data was collected using the modified Zarit Burden Interview (ZBI) and in-depth interviews from all 21 consecutive family caregivers. Data was analysed using IBM SPSS 23.0 for the quantitative data and thematic analysis for the IDIs. Results show that respondents suffer a huge socio-economic burden ranging from loss of social life (85.7%) to financial hardship (85.7%). Overall, respondents rate their burden as between moderate to severe range in caring for their sick ones. It is concluded that that caregivers of patients with end-stage renal disease experience a variety of socio-economic burdens in their caring roles, that require support (socially and economically). It is recommended that caregivers be better prepared psychosocially to enable them to cope effectively with the caring role. Health insurance coverage should be made available to cover more cost of managing people with end-stage renal disease to relieve the burden on the caregivers.