Browsing by Author "Hamid, A. A."
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Item Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.(University of Ilorin, 2015) Hamid, A. A.; Negi, A. S.; Zubair, M. F.; Oguntoye, S. O.; Aiyelaagbe, O. OEthyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines.Item Chemical Constituentss of Leaf Essential Oil of North-central Nigerian Grown Vitex Agnus-castus I(American-Eurasian Network for Scientific Information, 2010) Hamid, A. A.; Usman, L.A; Adebayo, S.A.; Zubair, M.F; Elaigwu, S.EPulverized leaf of vitex agnus-castus on hydrodistillation, afforded oil in the yield of 0.8%v/w. GC, GC/MS analyses of the oil revealed the abundance of hydrocarbon and oxygenated monoterpenes (53.2 and 24.5% respectively). The major constituents of the oil were; β-pinene (20.0%), viridiflorol (9.8%), α-pinene (9.1%), cis-ocimene (8.4%), 1,8-cineole (6.7%), β-farnesene (5.4%), terpinen-4-ol (4.2%), α-terpineol (4.1%) and β-phellandrene (4.1%).Item Preliminary Phytochemistry, Antibacterial and Antifungal Properties of extract of Asystasia gangetic Linn T. Anderson grown in Nigeria(Pelagia, 2011) Hamid, A. A.; Aiyelaagbe, O. O.; Ahmed, R. N.; Usman, L. A.; Adebayo, S. AThe hexane, ethylacetate and methanol extracts obtained from the whole plant of Asystasia gangetica were evaluated invitro to determine inhibition of human pathogenic microorganisms made up of six bacteria and six fungi. The crude extracts inhibited the growth of twelve test organisms to different degrees. All the bacteria strains were sensitive to all the extracts at concentration ranging from 50 to 200mg/mL using the agar diffusion pour plate method. The inhibition of these test organisms were concentration dependent, activity being higher at higher concentration of all the three extract. The extracts showed higher antifungal properties on Candida albicans, Penicillum notatum, Tricophyton rubrum and Epidermophyton floccosum with activity comparable to that of the reference drug. Tioconazole, Preliminary phytochemical investigation of the extracts revealed the presence of saponins, reducing sugar, steroids, glycosides, flavonoids and anthraquinones.