Browsing by Author "Femi-Akinlosotu O."

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    Alterations in the levels of female sex hormones following administration of nicotine to Wistar rats
    (Library and Publications Committee, University of Ilorin, 2019) Omotoso G.O.; Kadir R.E.; Alabi A.S.; Olayaki L.A.; Femi-Akinlosotu O.
    The indiscriminate use of nicotine is a serious public health challenge worldwide. In this work, the effect of nicotine was studied on female sex hormones using adult female Wistar rats. Fifteen (15) animals were grouped into three equally as, Group A (Control, given 0.1 ml of normal saline), Group B (given 0.03 mg/kg nicotine), and Group C (received 0.06 mg/kg nicotine). All administration was via the intraperitoneal route, once daily for five (5) consecutive days. All the animals were sacrificed by cervical dislocation about 24 hours after the last treatment, and intracardial blood samples obtained. Using appropriate biochemical kits, the serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, oestrogen and progesterone were determined. The results showed a dose-dependent significant increase in serum levels of the gonadotropins and progesterone, and a marked increase in serum levels of oestrogen and prolactin in animals treated with low dose nicotine, but significantly low levels of these hormones were recorded in animals treated with higher dose of nicotine. Administration of nicotine affects the female sex hormones adversely, and this by extension could affect female reproductive activities.