Browsing by Author "Erah, Patrick O."

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    Long-Term Effect of HAART on Biochemical Profiles of HIV/AIDS Patients in a Tertiary Health Facility in Benin City, Nigeria
    (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria, 2014-11) Bello, Shakirat I.; Onunu, Abel N; Erah, Patrick O.
    Purpose: To assess the long-term effect of highly active antiretroviral therapy (HAART) on biochemical parameters of HIV-infected patients in University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. Methods: HIV/AIDS patients on HAART for 2 - 8 years (297), those who were not on HAART (112, positive control), and healthy subjects (103, negative control) were recruited in the Infectious Diseases Clinic (IDC) of UBTH. Their sera were assayed for biochemical parameters. WHOQoL bref instrument was used to assess patients’ Quality of life (QoL). Results: Patients who have been on HAART had significantly elevated ALT and AST levels (p < 0.001) but mild liver toxicity. QoL of these patients was not significantly different from that of the healthy controls. The levels of Na+ (133.4 ± 5.2 mmol/l), K+ (3.6 ± 0.4 mmol/l) and Cl- (101.3 ± 4.0 mmol/l) were significantly lower in patients on HAART than those of the positive (137.5 ± 5.1, 3.9 ± 0.5, 104.3 ± 5.7 mmol/l respectively, p < 0.001). Also, levels of creatinine (0.8 ± 0.2 mg/dl), TBil (0.5 ± 0.2 mg/dl), and CB (0.3 ± 0.5 mg/dl) were significantly higher in patients on HAART than those of either the positive (0.7 ± 0.3, 0.4 ± 0.2, 0.2 ± 0.1 mg/dl) or negative (0.7 ± 0.3, 0.3 ± 0.1, 0.2 ± 0.1 mg/dl) controls respectively (p < 0.001). Conclusion: Treatment with HAART for 2 - 8 years may not produce severe hepatotoxicity in HIV/AIDS patient though mild liver toxicity should be expected. The patients’ QoL was not negatively affected by the use of HAART for 2 - 8 years.
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    Pharmacist’s Intervention in the Control of Blood Sugar Levels in Randomised Diabetes Patients at a Primary Health Care Setting in Benin City
    (College of Medicine, University of Lagos, Nigeria., 2012) Bello, Shakirat I.; Ganiyu, Kehinde A.; Dakop, Y. O.; Erah, Patrick O.
    Background: The extended roles of pharmacists in Nigeria in the improvement of quality of health care at the primary health care (PHC) level is currently poorly executed even though pharmacists have been proven to be involved in interventional activities in health care delivery. Objective: To evaluate pharmacists' intervention in the control of blood sugar levels of diabetes patients in a PHC setting in Benin City, Nigeria. Methods: At baseline, the fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), body mass index (BMI) and blood pressure (BP) of randomly selected 170 diabetic patients in a primary health care centre were evaluated. This was followed-up with intervention by the pharmacists through counselling on lifestyle modification, selfmedication and drug adherence on monthly basis for three consecutive months after which the FBS, HbA1c, BMI and BP were re-evaluated. Results: indicated significant reduction in BMI, HbAlc and FBS from 27.1±4.2 kg/m2, 8.1±3.0% and 10.0±4.2 mmol/l to 23.5±3.5 kg/m2, 7.1±1.8% and 8.5±2.1 mmol/l, respectively (p<0.001) was observed following the intervention by the pharmacists. Conclusion: Direct involvement of pharmacists in the care of diabetic patients in PHC settings can significantly improve the quality of life provided to these patients and hence reduce mortality resulting from the disease. Recruitment of reasonable number of pharmacists should always be considered in health policies for PHC settings in developing countries.