Browsing by Author "Eniayewu, O. I."

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    DETERMINANTS OF HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN ADULT PATIENTS UNDERGOING ANTI-MALARIAL TREATMENT AT A SECONDARY HEALTHCARE FACILITY IN ILORIN, NIGERIA
    (Nigerian Journal of Pharmaceutical Sciences, 2025-09) Giwa, H. B.; Shittu, H. D.; Babatunde, M. O.; Jamiu, O. M.; Aiyelero, O. M.; Eniayewu, O. I.; Giwa, A.; Abdul, A.; Atunwa, S. A.; Giwa, F. S
    ABSTRACT This study aimed to evaluate the health-related quality of life (HRQoL) and related factors among patients receiving antimalarial treatment at a General hospital Ilorin (GHI). Participants were drawn after a sample size of 291 participants were calculated. An EQ-5D-5L, EQ-VAS instrument was used to collect the data (from July to September 2023). Informed consent was obtained from all participants, and Ethical approval was obtained from Ministry of Health Ethical Research Committee (ERC) and Ethical Review and Research Committee of General Hospital Ilorin (GHI) with assigned number: ERC/MOH/2023/07/130 and GHI/ADM/134/VOL.I/081 respectively. Of the 291 participants included, 182 (62.5%) were female, and 109 (37.5%) were male. Most of the participants were aged 18–24 years (93; 32%), had tertiary education (195; 67%), and had low incomes, earning less than ₦3,000 (126; 43.3%). Also, a significant majority lacked health insurance (211; 72.5%). The most commonly used treatment was Artemether/Lumefantrine (281; 96.6%). The mean EQ-5D utility scores and EQ-VAS scores were 0.74 ±0.152 and 67.17±19.48 respectively. The EQ-5D descriptive system had 11111 as the health state of majority of participants 89(30.6%) followed by 11121 (19)6.5%, both states having utilities of 0.9 and 0.646 respectively. Sixty-three-point six percent of participants had problem in the pain and discomfort domain. The results of multivariate regression analysis showed marital status (p=0.005) and family history (p= 0.004) of any disease correlated with EQ-5D-5L index score (Health state). These variables contributed approximately 58.93% and 41.07% respectively to the EQ-5D index score of patients. The findings indicate that malaria patients in this study generally reported a good health-related quality of life. Most participants experienced minimal problems across domains except for pain/discomfort Socio-demographic factors such as marital status and family history of disease had significant influence on HRQoL, suggesting that social support and underlying health vulnerabilities play crucial roles in patients’ well-being. Overall, malaria’s impact on HRQoL extends beyond clinical symptoms, underscoring the need for patient-centered care that addresses both physical and psychosocial factors. Keywords: EQ-5D-5L, EQ-VAS, HRQoL, Malaria fever, Nigeria, Quality of life
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    Evaluation of heavy metal impurities in metformin tablet brands marketed in Ilorin, Nigeria
    (Faculty of Pharmaceutical Sciences, University of Ilorin, 2022-01) Bamidele, O. D.; Eniayewu, O. I.; Adegbola, A. J.; Salawu, K. M.; Njinga, N. S.; Abdullahi, S. T.
    The safety and quality of pharmaceutical products are important considerations for optimal therapeutic outcomes. Periodic assessment of heavy metals impurities in pharmaceutical products used for long- term treatment of chronic diseases is important to safeguard the health and well-being of patients. This study investigated the levels of manganese (Mn), copper (Cu), zinc (Zn), cadmium (Cd) and lead (Pb) in brands of metformin tablets commonly prescribed in Ilorin, Nigeria, for the management of diabetes. Five brands of commonly prescribed metformin tablets were randomly purchased from pharmacies in Ilorin, North-central Nigeria. Metal concentrations in the acid digested samples were profiled using Atomic Absorption Spectrophotometry (AAS) method. Method validation results showed excellent linearity (r2=0.9921(Mn), 0.9995 (Cu), 0.9998 (Zn), 0.9996(Cd), 0.9913(Pb)), with limits of detection (0.001, 0.001, 0.002, 0.002 and 0.025 mg/L for Mn, Cu, Zn, Cd and Pb respectively) and limits of quantification (0.003, 0.003, 0.006, 0.006 and 0.076 mg/L for Mn, Cu, Zn, Cd and Pb respectively) in the concentration ranges of 2– 10, 0.2–1.6, 0.2–1.6, 1–4 and 1–4 mg/L for Mn, Cu, Zn, Cd and Pb respectively. Mn, Cu, and Zn were detectable in varying concentrations in all the five brands of metformin evaluated in this study while none of the brands contained Cd and Pb at detectable levels. The levels of Mn, Cu and Zn ranged between 0.031-0.062, 0.085-0.112 and 0.040-0.130 mg/mL respectively across the brands. The highest concentrations of Mn, Cu and Zn were 0.062(0.001), 0.112(0.001) and 0.130(0.001) mg/L respectively. Similarly, maximum daily ingestible amounts for Mn, Cu and Zn ranges between 0.84-1.75, 2.17-3.03 and 6.12-20.7 μg/day respectively, which were below permissible daily exposure (PDE). These results indicate that all the metformin brands evaluated could be safely administered orally to the patients without fear of any of the metal’s toxicity consequences.