Browsing by Author "Egharevba, G. O.,"

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    Effects of Ultra-Violet, Red and Sun Light on the Stability of Phytochemicals, Antiradical and Antimicrobial Activity of Ocimum gratissimum Linn. (Lamiaceae).
    (East and Central African Journal of Pharmaceutical Sciences., 2020-04-01) Njinga, N. S.,; Bakare-Odunola, M. T.,; Abdullahi, S. T.,; Abdulmajeed, F. F.,; Bello, R. H.,; Saadu, R. A.,; Aliyu, M.,; Egharevba, G. O.,; David, B. O. and; Shittu, A. O
    The content and stability of phenols, flavonoids, saponins and alkaloids in Ocimum gratissimum upon exposure to sunlight, red and ultra-violet (UV) radiation over a period of 168 h was investigated as well as the effect of irradiation on its antiradical and antimicrobial activities. Total phenolic, flavonoids, saponins and alkaloid contents were determined using standard methods while antiradical and antimicrobial analyses were determined using 1,1-diphenyl-2-picrylhydrazyl and agar diffusion methods, respectively. Exposure to sunlight significantly increased (p<0.05) the total phenolic and alkaloid contents. Ultra-violet and sun light significantly decreased the total flavonoid and saponin content, while all the three forms of radiation significantly increased antiradical activity as well as antimicrobial activity against Staphylococcus aureus. Red and UV light significantly increased the activity against S. aureus while UV light increased activity against Escherichia coli. These findings suggest photochemical instability with increased antiradical and antimicrobial activities of the methanol extracts of O. gratissimum after irradiation.