Browsing by Author "Durotoye, Idayat"
Now showing 1 - 5 of 5
Results Per Page
Sort Options
Item An Evaluation of Inflammatory and Nutritional Status of Breast Cancer Outpatients in a Tertiary Hospital in Nigeria(Journal of Nutrition and Cancer., 2021-01-07) Izuegbuna, Ogochukwu O.; Olawumi, Hannah O.; Olatoke, Samuel A.; Durotoye, IdayatAim: To assess the relationship between nutritional status and inflammatory markers of breast cancer patients, and to identify predictors of malnutrition in these patients. Methods: This is a cross-sectional study of 45 patients with breast cancer assessed between January and June 2018. Nutritional status was evaluated by objective and subject- ive methods. The inflammatory markers and inflammation-based scores evaluated were C- reactive protein (CRP), albumin, erythrocyte sedimentation rate (ESR), Glasgow Prognostic Score (GPS), CRP/albumin ratio, and Albumin/CRP ratio. Results: A total of 45 patients were evaluated. Majority of the patients have high levels of both CRP and ESR (73.3% and 86.7% respectively). More than 70% of the patients were well nourished. There was no significant association between CRP (P¼0.067), ESR (P¼0.094) and SGA (Subjective Global Assessment) categories. Albumin (P<0.001), Albumin/CRP ratio (P¼0.002), CRP/albumin ratio (P ¼ < 0.001), and GPS (P<0.001) were significantly associ- ated with SGA categories. On multivariate analysis, albumin (P<0.001), Albumin/CRP ratio (P¼0.004), CRP/albumin ratio (P¼0.009), GPS (P¼0.01), and ECOG (P¼0.009) were the only markers independently related to malnutrition. Conclusion: The inflammation-based scores were significantly associated with malnutrition and can be used as biochemical nutritional assessment tools in cancer patients.Item Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria(2018) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat MBackground: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.Item IMMUNE THROMBOCYTOPAENIC PURPURA IN PREGNANCY: A CASE OF NEAR MISS MORTALITY IN A NIGERIAN.(SOGON, 2013-04) Adesina, Kikelomo; Fawole, Adegboyega; Durotoye, Idayat; Aboyeji, Abiodun; Musa, Omoyine; Olarinoye, Adebunmi; Eno, Enang; Adepoju, AyodejiThrombocytopenia occurs in pregnancy like in the non-pregnant state and can be due to immune thrombocytopaenic purpura (ITP). The hyperoestrogenic state of pregnancy has been identified as a precipitating factor. This is a case report of a thirty year old Nigerian lady, who at a gestational age of 26 weeks developed ITP as a near miss mortality. Although, most literatures reported that the perinatal outcome is usually favourable in this condition, we report a case managed in our facility that had intrauterine death and non- remission until delivery; despite corticosteroid therapy and transfusion of eleven (11) units of blood. This report is relevant in a developing world where a rare condition almost caused a maternal death in spite of the high maternal mortality rates from other conditions. Baseline full blood count is advocated at booking to identify and monitor rare haematological disorders like this in pregnancy.Item PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria(2016) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola S; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat M; Ogunfemi, Mutiat KObjectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is underreported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM®SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of preeclampsia.Item Pertinent Roles of African Higher Institutions in The COVID-19 Pandemic Response: The University of Ilorin, Ilorin, Nigeria; An African Model(Wiley-Blackwell, USA., 2020) Durotoye, Idayat; Odunola, R; Adeyemi, Oluwapelumi Olufemi; Akanmu, A; Bolarinwa, O; Adeboye, O; Abdullahi, A; Bolajoko, Z; Durosinmi, W; Adebisi, G; Aduloju, V