Browsing by Author "David, John Ohieku"

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    Antiretroviral drug adverse reactions among HIV-positive patients at a tertiary care hospital in North-Eastern Nigeria
    (Journal of Science and Practice of Pharmacy, 2020-12) Bello, Shakirat Iyabo; David, John Ohieku; Ikunaiye, Nasiru Y; Kida, Ibrahim M
    Purpose: The objective of this study was to evaluate the prevalence of adverse drug reactions (ADRs) among patients on antiretroviral drugs in a tertiary healthcare facility in Maiduguri, NorthEastern Nigeria. Methods: The study was conducted among HIVpositive participants using validated questionnaires and personal interviews to obtain information on ADRs. Participants’ case notes were used to capture data on socio-demographic characteristics, clinical variables, and treatment profiles. The data collected were analyzed with STATA 10 software using logistic regression and descriptive analyses. Results: The prevalence rate of ADRs was 26.6% among 134 patients. Gastrointestinal system disorders 40(8.0%), central and peripheral nervous system 38(7.5%), and systemic signs and symptoms 37(7.3%) were the most common clinical ADRs observed. Zidovudine/Lamivudine/Nevirapine combination therapy was mostly implicated for the ADRs. Logistic regression analysis showed that the occurrence of ADRs was associated with marital status, viral load, and Zidovudine/Lamivudine/Nevirapine therapy. Conclusion: The prevalence of ADRs reported in this study was low. Most of the patients with ADRs had mild effects. Marital status, viral load, and Zidovudine/Lamivudine/Nevirapine contributed to the development of the ADRs. There is a need to closely monitor HIV-infected patients by caregivers to further reduce the prevalence of ADRs and concomitant risks.