Browsing by Author "Busari, A.O.,"

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    Ethanolic Extract of Nauclea latifolia (African Peach) Protects Against Ethanol-Induced Gastric Mucosal Injury in Rats.
    (Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.; Abubakar, M.M
    Nauclea latifolia is widely used in folk medicine in Nigeria and some West African countries. In vivo study was conducted to investigate the gastroprotective effects of ethanolic leaf extract of N. latifolia (EENL) on ethanol-induced gastric ulcerated rats. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric secretion parameters and ulcerated areas were assessed. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal ulceration. Conclusion: The study suggests that EENL has a protective action against gastric ulcers induced by ethanol in Wistar rats. The protective effect might be mediated via antisecretory and cytoprotective mechanisms.
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    Evaluation of serum creatine kinase and lactate dehydrogenase activities in hypertensive patients attending General Hospital Ilorin, Kwara State, Nigeria,
    (Faculty of Health Sciences, Al-Hikmah University Ilorin, Nigeria, 2021) Busari, A.O.,; Onamadi, T.O.,; Ibrahim, M.,; Balogun, M.E.; Garba, W.O.,; Ogunwale, K.T.,; Adunmo, G.O.,; Ahmad, M.B.; Mohammed, I.Y.,; Nassar, S.A.,; Akinola, F.F.,; Popoola, A.N.,; Lawal, A.Z.,; Oyeniyi, M.G.; Eleha, S.
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    Histological Changes and Lipid Profile Analysis in Male Rats Exposed High Fat Diet
    (Society for Basic and Clinical Toxicology Nigeria, 2022) Ibrahim M.,; Lawal, A.Z.,; Ogunwale, K.A.,; Falusi, T.A.,; Garuba, W.O.,; Popoola, A.N.,; Adunmo, G.O.,; Suleiman, I.E.,; Busari, A.O.,; Balogun, M.O.,; Nuhu, A.
    Background: High Fat Diet (HFD) is associated with development of cardiovascular, metabolic, liver and central nervous system diseases. The study is aimed at evaluating the effects of high fat diets on lipid profile and selected organs in male wistar rats. Methodology: 24 rats were randomly assigned into 4 groups. Group A received Normal Rat Chow diet + Distilled Water (DW), Group B fed 25% HFD + DW, Group C fed with 50% HFD + DW and Group D fed 100% HFD + DW. Animal’s weights were measured pre and post-treatment. Rats were anaesthetized (diethylether) and sacrificed after 12 hours fast. The blood samples taken from the orbital sinus, centrifuged and serum obtained was used for the assay of lipoprotein A, Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). The brain, liver and heart were excised and processed for histology. Results: Result showed the presence of a significant dose dependent increase (p < 0. 0 5) in the body weight, concentrations of TC, TAG, LDL, lipoprotein A and decrease in the concentrations of HDL in HFD groups compared with the control. Histological results from HFD treated rats have showed no histological abnormalities of the liver, brain and heart tissues. Conclusion: Intake of high fat diets in this study altered serum lipid profile with significant weight gain - a risk factors for cardiovascular and metabolic diseases.
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    Nauclea Latifolia (African Peach) Attenuates Gastric Acid Secretion in Rats with Ethanol-Induced Ulceration
    (Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Umahi, G.O.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.,; Yusuf, R.O.; Ojulari, L.S
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    Selected liver function indices in Male farmers exposed pesticides.
    (Faculty of Health Sciences, Al-Hikma University., 2023) Lawal A.Z.,; Ibrahim M.,; Mohammed, Z, N,,; Ogunwale, K. A.,; Wasiu, O.G.,; Popoola, A.N.,; Adunmo, G.O.,; Suleiman, I.E.,; Busari, A.O.,; Balogun, M.O.,; Ibironke, E.,; Adekunle, C.,; Adedotun, M.; Nuhu, A.
    Introduction: Exposure to environmental toxins and ensuing liver health outcomes has attracted global attention. This study was aimed at assessing the liver function indices among farmers exposed to pesticides. Methodology: This research was carried out on 130 apparently healthy male participants aged 18 years and above. The participants were randomly selected for this comparative cross-sectional study. The participants were further divided into two groups; the Pesticide-exposed group and the control group (non-exposed). Demographic characteristics of the participants were obtained by standard methods. Five milliliters of fasting blood samples were collected from each participant after an overnight fast (8 to 12 hours). A portion of the blood sample was dispensed into plain tubes for the estimation of serum Aspartate aminotransferase, alanine aminotransferase, albumin, and total protein. Statistical Package for Social Science (SPSS) 25.0 software was used for statistical analysis. Results: The results from this study suggest that exposure to pesticides may have adverse effects on the liver as evidenced in the observed significant (p ≥ 0.05) increase in serum AST, ALT, and decreased Albumin and Total protein values in the pesticide-exposed group when compared with the normal control.