Browsing by Author "Biobaku, K.T"

Now showing 1 - 3 of 3
  • Item
    Haemato-biochemical changes following inhalational exposure to commercial grade pyrethroid mixture in male Wistar rats
    (Faculty of Veterinary Medicine, University of Ilorin, 2018-02) Okediran, B.S; Ajayi, O.V; Suleiman, R; Adah, A.S; Biobaku, K.T; Adam, M; Suleiman, K.Y; Sanusi, F
    Introduction: Pyrethroid insecticides are widely used for control of insects such as ticks and flies which may act as disease vectors. During usage, these pyrethroids are absorbed not only by the target parasites but also by the host. We investigated the haematological and some biochemical changes that may occur as a result of daily exposure to pyrethroids via inhalation for seven days in male Wistar rats at varying concentrations. Methods: A total of sixteen male Wistar rats used for this investigation were divided into four groups: A-D. Group A served as the control unexposed while groups B-D were exposed to 0.04; 0.08 and 0.16mg/ml of pyrethroid (0.05% imiprothrin, 0.05% prallethrin and 0.015% cyfluthrin) respectively daily for seven days. Results: The results showed a significant reduction in packed cell volume, mean corpuscular haemoglobin and haemoglobin concentrations, while there was also a significant increase (p < 0.05) in activities of aspartate aminotransferase and alanine aminotransferase while protein, creatinine and urea concentrations were equally elevated. Significance: Repeated exposure to pyrethroid continuously over a period of seven days resulted in alteration of haematological and biochemical parameters predisposing the rats to microcytic hypochromic anaemia and perturbation of protein metabolism.
  • Item
    Haematological and antioxidant enzyme response to lead toxicity in male wistar rats
    (University of Peradeniya, 2017) Okediran, B.S; Biobaku, K.T; Olaifa, Folashade Helen; Atata, A.J
    The study evaluated the haematological and some antioxidant enzymes response to lead toxicity in male Wistar rats. Twenty male Wistar rats were divided into four groups viz., A, B, C and D. Group A served as the control while groups B, C and D were treated with 200, 300 and 400 ppm of lead (Pb) as lead acetate, respectively. Doses were orally administered in divided doses by intubation to ensure that each rat had the specified doses, after which they have access to water and feed. At the end of two weeks of treatment, blood samples were collected via the median canthus into heparinised tubes for blood lead determination and haematological analysis after which the remaining blood was centrifuged to obtain the plasma for determination of malonydialdehyde, catalase, superoxide dismutase and peroxidase levels. There was a significant increase in blood lead concentrations ranging from 2.15±0.10 μg/dl to 9.21±0.05 μg/dl which was dose dependent while decreases in packed cell volume and the red blood cell counts ranging from 32-53% and 15-52%,respectively. At the highest dose of 400 ppm of lead there was significant decrease in the neutrophils and lymphocytes. There was significant (P<0.05) dose dependent increases in malondialdehyde while the activities of catalase, peroxidase and superoxide dismutase were significantly (P<0.05) reduced. In conclusion, lead disrupts the haematological system leading to generation of free radicals that overwhelm the antioxidant enzymes thus leading to oxidative stress.
  • Item
    Potentials of Honey: Fertility Booster and Garnish of Semen Quality in Bucks (West African Dwarf) Goat.
    (Published by the Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri., 2017) Raji, L.O.; Iliyasu, D; Jubril, A.T.; Biobaku, K.T; Ameen, S.A.; Azeez, M.O.; Aremu, A.; Basiru, A.; Akorede, G.J.; Maina, A.V.
    This study was designed to investigate the value of honey as a potential fertility booster in west african dwarf bucks. 12 WAD bucks were divided into groups A and B i.e treated and untreated groups respectively. Findings suggest honey is a potential fertility booster in WAD bucks. We therefore recommend its inclusion in the diet of WAD bucks for breeding programme.