Browsing by Author "Biliaminu, Sikiru Abayomi"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Effects of Jatropha curcas seed extract on reproductive functions in female Wistar rats(Bangladesh Society of Physiologists (BSP), 2021) Ayinde, Taofeek, Olanrewaju; Adetokunbo, Azeez, Olaniyi; Biliaminu, Sikiru Abayomi; Ojulari, Sheriff Lekan; AbdulAzeez, M.I.; Faramade, Adeleke Alani; Maruf Eyitayo Balogun; Afodun, Adam Moyosore; Liadi, Muideen Tella; Belewu, Moshood AdewaleBackground: Jatropha curcas is a multipurpose plant with several industrial and medicinal importance. Its seeds contain many active compounds that are used as medicines with anti inflammatory, and antioxidant activity. Objective: The objective of this study is to evaluate the effects of extract of Jatropha curcas seed which is patronized locally in some communities as agent of preventing childbirth on reproductive functions in female Wistar rats. Methods: Twenty-four animals were randomly divided into four groups of 6 rats each. Group I was administered normal saline and served as control. Groups II, III and IV were given the seed extract orally at doses of 100mg/kg, 200mg/kg and 400mg/kg body weight respectively daily for 14days orally. The animals were euthanised and blood samples collected for oestrogen, progesterone, FSH and LH assay. Statistical analysis was done using statistical package for social sciences (SPSS). Differences in means was obtained using ANOVA test. All values reported in the study were expressed as mean ± SEM. Differences in mean was taken to be significant at P<0.05. Results: There was significant reduction (p<0.05) in levels of progesterone, LH and FSH in moderate and high doses of the extract. But estrogen level was significantly (p<0.05) decreased in both low and moderate doses, while the high dose showed significant (p<0.05) increase. Conclusion: There was alteration in reproductive hormones due to arrest of development of ovarian follicles. This gives it the propensity of exhibiting contraceptive activity.Item Prevalence of Hypertension and Relationship with Anthropometric Indices in Urban Dwellers in Kwara State, Nigeria(Medical Research Society, College of Health Sciences, Nnamdi Azikiwe University, Awka, Nigeria, 2023-03-01) Olanrewaju, Timothy Olusegun; Aderibigbe, Ademola; Popoola, Ademola; Buhari, Mikhail Olayinka; Adedoyin, Olanrewaju Timothy; Kuranga, Sulyman Alege; Biliaminu, Sikiru Abayomi; Chijioke, Adindu; Ajape, Abdulwahab Akanbi; Dada, Samuel Ayokunle; Obajolowo, OmotolaBackground: Hypertension is a growing public health concern with a rising prevalence and associated clinical outcomes, particularly in Nigeria. The association of hypertension with anthropometric indices is insufficiently described in Nigeria. Objectives: We aim to determine the prevalence of hypertension and its relationship with anthropometric indices. Materials and Methods: This is a cross-sectional study of adults in seven urban communities in Kwara State, Nigeria. The study was done during World Kidney Day over a seven year period (2007-2015). Blood pressure, body mass index, waist circumference, and hip circumference were measured. Hypertension was defined as blood pressure ≥ 140/90mmHg. Results: One thousand five hundred and six adults were recruited, with a mean age of 44 ± 14 years, and a female preponderance (55%). The prevalence of hypertension was 30%, (30.2%) in males and (29.8% in females). Hypertension correlates significantly with age (r = 0.416, P = 0.001), BMI (r = 0.301, P = 0.001), hip circumference (r = 0.219, P = 0.001), waist-hip ratio (r = 0.225, P = 0.005), and waist circumference (r = 0.063, P = 0.045). The identified predictors of hypertension were; waist circumference had about 17% increased risk for hypertension (OR = 1.169, CI = 1.021 – 1.340, P = 0.024), body mass index, 11% (OR = 1.113, CI = 1.059–1.170, P = 0.001), and age 5% (OR = 1.052, CI = 1.034 – 1.070, P = 0.001).Conclusion:The prevalence of hypertension is high in urban population of Kwara State, and is similar in men and women, but it increases with age, high body mass index, and waist circumference.