Browsing by Author "Biliaminu, Sikiru A"
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Item Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria(2018) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat MBackground: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.Item PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria(2016) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola S; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat M; Ogunfemi, Mutiat KObjectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is underreported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM®SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of preeclampsia.Item Relationship between serum zinc levels and socio-demographic features in Nigerian children with acute lower respiratory infections.(2020-11) Ibraheem, Rasheedat M; Johnson, Abdul-Wahab BR; Gobir, Aisha A; Biliaminu, Sikiru A; Adedoyin, Olanrewaju TBackground: Acute Lower Respiratory Infections (ALRI) are a major cause of Paediatric morbidity for which several risk factors have been identified. Among these factors are socio-demographic and nutritional factors including micronutrients such as zinc and Vitamin A. The current study was carried out in Ilorin, Nigeria to determine the relationship between serum zinc levels and some socio-demographic characteristics in children with ALRI. Method: This was a descriptive cross-sectional study involving children aged two months up to 60 months with ALRI. Socio-demographic and clinical data were obtained via a semi-structured questionnaire. Blood samples were collected for determining the serum zinc level. The serum zinc was analyzed with a Jenway™ spectrophotometer after initial preparation with the QuantiChrom™ zinc assay kit. The data collected was analysed with SPSS 16 software package. Results: Of the 120 children recruited, 73(60.8%) were males and 47(39.2%) females. The mean (SD) age of the children with ALRI was 20.8(17.6) months. Nine (7.5%) children had bronchiolitis, 16(13.3%) had lobar pneumonia and 95(79.2%) bronchopneumonia. Children from monogamous families had mean (SD) serum zinc level of 19.6(12.2) µg/dl which was significantly higher than the corresponding value of 13.1(7.7) µg/dl recorded in those from polygamous homes, p=0.031. After a stepwise linear regression analysis, the family type remained significant with an F value of 4.244; p=0.042; 95%C.I.(-12.4 - -0.3). Conclusion: Children with ALRI from polygamous homes have low serum zinc levels. The family type is a predictor of serum zinc level in children with ALRI.Item Urinary iodine levels of primary school children in Ilorin, Nigeria(2020) Olasinde, Yetunde T; Adesiyun, Omotayo O; Olaosebikan, Rasak R; Olasinde, Adeola; Ibraheem, Rasheedat M; Biliaminu, Sikiru A; Areola, Emmanuel D; Ernest, Samuel KBackground: Iodine deficiency is one of the commonest micronutrient deficiencies. Globally, it is the commonest cause of preventable mental retardation and also associated with impaired physical growth. The current iodine nutrition of school children in Ilorin, North-Central Nigeria is not known. Objective: The study aimed to determine the urinary iodine levels (UIL) of school children in Ilorin and explored the relationship with socio-demographic variables. Methods: This cross-sectional study was carried out among primary schools children in Ilorin, Nigeria. We recruited school children aged 6-12 years through a multi-staged sampling method. Relevant data including socio-demograhic variables were obtained with a pretested study proforma. The recruited school children had urinary iodine determined using the Sandell-Kolthoff method. Data analysis was with Statistical Package for Social Sciences version 20.0. Results: The median with interquartile range (IQR) of urinary iodine level was 117.2 (99.6-148.6) g/L. Of the 480 recruited children, 336 (70.0%) had normal urinary iodine levels while 144 (25%) had mild iodine deficiency and two (0.4%) had excess urinary iodine levels. Pupils with iodine deficiency was higher among public schools than those in private schools (33.3% vs 23.6%, 2= 150.149, p < 0.022). The median UIL of the age-group 6-9 years was higher than the 10-12year age group (p = 0.026). However, the median UIL values were comparable across gender, socioeconomic strata and mother’s educational level. Conclusions: This study showed that a quarter of the children still had mild iodine deficiency despite salt