Browsing by Author "Bello, M.K."

Now showing 1 - 4 of 4
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    Acute and Sub-acute Toxicities of Defatted Ethanolic Extract of Moringa Oleifera seed in Albino Rats
    (West African Society for Pharmacology, 2015) Olorundare, O.E.; Bello, M.K.; Biliaminu, S.A.; Babatunde, A.S.; Ibrahim, O.O.K.; Anoka, A.A.
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    Phytochemical, elemental, antioxidant, antimicrobial and hypoglycemic studies of a mixed herbal product used for the management of diabetics
    (Faculty of Pharmaceutical Sciences, University of Jos, 2018) Bakare-Odunola, M.T.; Njinga, N.S.; Ayaniyi, R.O.; Bello, M.K.; Abdullahi, S.T.; Eniayewu, O.I.; Abdulmajeed, F.F.; Bello, H.R.
    Medicinal plants are important sources of disease-preventing compounds, which are important for the treatment of various health challenges such as diabetes. On an aqueous extract of a herbal product (HP) used for the management of diabetes, total phenolic and flavonoid contents were determined by Folin-Ciocalteu reagent and AlCl3 method respectively. Microbiological evaluation was done by determining the total viable, yeast, mould and coliform bacteria count. The elemental analysis was carried out using atomic absorption spectrometer. The acute toxicity was done using Organization for Economic Cooperation and Development guideline while the hypoglycemic activity was evaluated using alloxan-induced diabetic rats. Flavonoids, saponins, alkaloid, cardiac glycoside, steroids and terpenoids were detected in the HP. Total flavonoid and phenolic contents obtained was 1.58±0.001mg/g quercetin equivalent and 10.84±0.003 mg/g gallic acid equivalent respectively. Heavy metals Fe and Zn were present while Cu, Cd, Cr and Pb were absent. Na and K were also present at concentrations of 3.90 and 2.20mg·kg−1 respectively. The total viable and coliform counts were found to be 1.34 x 105and 9.0 x 104 cfu/g respectively while there was absence of mould and yeast in the HP. The LD50 of the HP was found to be above 5000 mg/kg. At dose of 125 mg/kg, the HP significantly (P<005) reduced glucose level to 143 mg/dL after 4 hours and to 123 mg/dL after 8 hours. The phytochemicals present, safety and the anti-diabetic activity justify the use of this HP in the management of diabetes.
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    Phytochemical, elemental, antioxidant, antimicrobial and hypoglycemic studies of a mixed herbal product used for the management of diabetics
    (Faculty of Pharmaceutical Sciences, University of Jos, 2018-08-24) Bakare-Odunola, M.T; Njinga, N.S; Ayanniyi, R.O; Bello, M.K.; Saad, S.T
    Medicinal plants are important sources of disease-preventing compounds, which are important for the treatment of various health challenges such as diabetes. On an aqueous extract of a herbal product (HP) used for the management of diabetes, total phenolic and flavonoid contents were determined by Folin-Ciocalteu reagent and AlCl3 method respectively. Microbiological evaluation was done by determining the total viable, yeast, mould and coliform bacteria count. The elemental analysis was carried out using atomic absorption spectrometer. The acute toxicity was done using Organization for Economic Cooperation and Development guideline while the hypoglycemic activity was evaluated using alloxan-induced diabetic rats. Flavonoids, saponins, alkaloid, cardiac glycoside, steroids and terpenoids were detected in the HP. Total flavonoid and phenolic contents obtained was 1.58±0.001mg/g quercetin equivalent and 10.84±0.003 mg/g gallic acid equivalent respectively. Heavy metals Fe and Zn were present while Cu, Cd, Cr and Pb were absent. Na and K were also present at concentrations of 3.90 and 2.20mg·kg−1 respectively. The total viable and coliform counts were found to be 1.34 x 105and 9.0 x 104 cfu/g respectively while there was absence of mould and yeast in the HP. The LD50 of the HP was found to be above 5000 mg/kg. At dose of 125 mg/kg, the HP significantly (P<005) reduced glucose level to 143 mg/dL after 4 hours and to 123 mg/dL after 8 hours. The phytochemicals present, safety and the anti-diabetic activity justify the use of this HP in the management of diabetes.
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    Sub-Acute Toxicological Evaluation of An Artemisia-Based Moringa Supplement (AMS)
    (Published by the College of Health Sciences, University of Ilorin, 2025) Afolabi, Saheed O.; Olorundare, O.E.,; Akanbi, O.B.,; Bello, M.K.; Folahan, J.T; Ibiyemi, S
    Background: In developing nations, several natural medicine practitioners explore the use of plant-based supplements and other forms of phytotherapies to combat viral infection via immune-boosting mechanisms. One such supplement is a locally compounded and consumed Moringa supplement containing and named, artemisia-based Moringa supplement (AMS). The aim of this study was to evaluate the effect of a subacute (30 days) administration of AMS on the toxicological indices in albino Wistar rats of both sexes. artemisia annua Results: There were no adverse hematological effects because of AMS treatment. Serum electrolytes levels were not affected across the doses of AMS administered for 30 days. Creatinine levels were not significantly altered, however a significant (p = 0.037) reduction in urea level was observed in the highest dose of 500 mg/kg. Liver function assays showed no significant alterations in the liver function enzymes, although, a significant decrease in the liver malonaldehyde (MDA, product of lipid peroxidation) level was observed. There was no adverse effect on kidney function parameters and serum lipid profile.