Browsing by Author "Bello, A."

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    Inhibition of dipeptidyl peptidase-4 averts Free Fatty acids deposition in the hearts of oral estrogen-progestin contraceptive-induced hyperinsulinemic female rats.
    (Canadian Science Publishing., 2021) Adegoke, T.E.; Sabinari, I.W.; Areola, E.D.; Ajao, F.O.; Asafa, O.O.; Soluoku, T.K.; Bello, A.; Adesanmi, A.M.; Yusuf, S.O.; Omoleye, A.O.; Ayinla M.T; Olatunji, L.A.
    Free fatty acid (FFA) deposition in non-adipose tissues such as the heart is a characteristic of insulin resistant states which feature hyperinsulinemia and dipeptidyl peptidase-4 (DPP-4) activation. Estrogen–progestin oral contraceptives (OC) treatment reportedly increased DPP-4 activity in rat tissue, and DPP-4 inhibitors have anti-diabetic and anti-inflammatory properties. This study aims to investigate the effects of DPP-4 inhibition on cardiac FFA deposition in estrogen–progestin-treated female rats. From our data, estrogen–progestin OC exposure in female rats led to elevated plasma insulin, cardiac DPP-4 activity, FFA and triglyceride (TG) accumulation, TG/high-density lipoprotein cholesterol (TG/HDL-C) ratio, adenosine deaminase/xanthine oxidase/uric acid pathway (ADA/XO/UA), lipid peroxidation, glycogen synthase activity, and alanine phosphatase; whereas cardiac glucose-6-phosphate dehydrogenase, Na+/K+-ATPase and nitric oxide (NO) were decreased. However, DPP-4 inhibition resulted in decreased plasma insulin, cardiac DPP-4 activity, FFA, TG, TG/HDL-C ratio, and alkaline phosphatase. These were accompanied by reduced ADA/XO/UA pathway, lipid peroxidation, and augmented NO and Na+/K+-ATPase in estrogen–progestin OC-treated rats. DPP-4 inhibition attenuated cardiac lipid deposition accompanied by reduced activity in the ADA/XO/UA pathway in estrogen–progestin OC-treated female rats. DPP-4 is therefore a plausible therapeutic target in cardiometabolic disorders.
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    Knowledge of the Predisposing Factors of Ascariasis Disease among Primary Teacher in Kwara State
    (The Department of Health Promotion and Environmental Health Education, 2019-01) Ologele, I; Bello, A.; Jidda, K. A.; Abdullahi, M. B.; Stephen, J. A.
    Ascariasis (roundworm) is an important health issue that is affecting people mostly in less developed countries which It has been associated with causing stunting growth, body weakness, nutritional disturbances, morbidity, mortality and low educational achievement among school children and even in adults The objectives of the study were to investigate whether poor knowledge of personal hygiene and food hygiene were predisposing factors of ascariasis among public primary school teachers in Kwara State. The study adopted a descriptive research design of the survey type. The population of the study comprised of all the public primary school teachers in Kwara State (11.963) Multistage sampling techniques of cluster. proportionate, purposive proportionate, and simple random sampling techniques were used to select 470 public primary schools teachers in Kwara state as a sample for the study. The Research instrument adopted for the study was researchers structured questionnaire which had been validated by three experts in the Department of Health Promotion and Environmental Health Education. University of Ilorin to ensure both face and content validity. Reliability of the instrument used for the study was established through a split-half method. Twenty (20) copies of the questionnaire administered on twenty public primary school teachers outside the study area and their responses analysed using Cronbach alpha. The correlation coefficient of 0.71r was obtained. The result of the reliability indicated that the instrument was reliable. The result of data collected analysed using frequency counts and percentages. The finding of the study revealed that primary school teachers in the study area know that poor personal hygiene and poor food hygiene are a predisposing factor for ascariasis. It was recommended that the Kwara State Universal Basic Education (KWSUBE) should carry out an educative programme that will enlight both primary school pupils and teachers on the need for them to always wash their hands with soap and water after visit toilet and before handling or eating food to protect them against ascariasis