Browsing by Author "Babamale, A.O"

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    Alterations in T-helper cell type 1 and blood cell parameters in malaria-infected patients
    (2017) Babamale, A.O; Abdulkareem, A.O; Opeyemi, O.A; Ugbomoiko, U.S
    Malaria is a global public health disease. Haematological and cytokine alterations are the major sources of its pathological conditions. Therefore, blood and serum of patients attending health centres were screened to investigate the effects of Plasmodium falciparum on the T-helper cell type 1 and blood cell parameters using Enzyme linked immunosorbent assay and automatic hematology analyzer respectively. Approximately 55% of malaria-infected patients with average parasitaemia of 2523.64 parasite/ll of blood concurrently suffered anaemia, thrombocytopenia, leucopenia, microcytosis and hypochromasia. However, thrombocytopenia and leucopenia were age-specific and their prevalences in children within 10 years were higher. These disease conditions significantly vary with severity of malaria infection (p < 0.05). Blood parameters with the exception of RBC and MCHC were significantly lower in the infected patients (p < 0.05) with 12.9% and 41.2% reduction in haemoglobin and platelet counts respectively. A high plasma concentration of IL-10, IL-12, INF-c and TNF-a, ratio of IL-10/TNF-a (1.86) and IL-10/INF-c (1.55) were recorded among the malaria-infected groups. This study revealed that unregulated interac tion of the parasite with host immune response has important consequences in disease progression and thus relevant for therapeutic and vaccine development.
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    Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients
    (2017-07-15) Babamale, A.O; Abdulkareem, A.O; Ahmed, A.O; Afolayan, A.M; Ugbomoiko, U.S
    Abstract Interaction between malaria, anaemia and mal nutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Sa haran Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorp tion spectrophotometer respectively. A total of 123 (55.2%) of our study population were positive of Plas modium falciparum. Infection was age-specific (p\0.0001), and a significant proportion (88.6%) of malaria infected patients were 28.5% mild, 45.5% moder ate and 14.6% severely anaemic. The severity of anaemia increases as parasite density increases. Analysis of serum micronutrients revealed a significant low level of iron (3.72 mg/l), copper (2.05 mg/l) and zinc (3.67 mg/l) in infected patients (p \ 0.0001); which further increased their anaemic condition. This study confirmed a significant relationship between severity of anaemia and nutritional deficiency in the pathogenesis of malaria infection. We therefore, recommend that immunomodulation potential of micronutrients may be essential in the management of malaria infection.