Browsing by Author "Ayinla, M.T."

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    Antinociceptive effects of lead acetate in sciatic nerve chronic constriction injury model of peripheral neuropathy in male wistar rats.
    (Springer on behalf of German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT)., 2021) Owoyele, B.V.; Bakare, A.O.; Ayinla, M.T.; Adeshina, K.A.; Onietan, D.; Azeez, S.O.
    The toxicological effects of lead and its compounds have overshadowed its possible health beneficial effects. Currently, the success rate for treating neuropathic pain has been very low. This study investigated the antinociceptive effects of orally administered low dose lead acetate in sciatic nerve ligated Wistar rats. Thirty Wistar rats randomly divided into five groups were used for this study. Chronic constriction injury (CCI) was used to induce neuropathic pain in Wistar rats. Allodynic and hyperalgesic signs were investigated using von Frey filaments and hotplate, respectively. Morris water maze test was used to assess the memory functions of the rats. The study revealed that oral administration of low-dose lead acetate significantly (p < 0.05) increased pain thresholds of ligated rats. CCI enhanced memory function in Wistar rats which was significantly decreased following lead acetate administration. The findings suggest that lead acetate possesses antinociceptive effects in peripherally induced neuropathic pain model in Wistar rats.
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    Effect of Chronic Administration of Caffeine on Plasma Testosterone Level and Body Mass Index in Male Wistar R
    (Nigerian Society for Experimental Biology, 2021) Ayinde, T.O.; Balogun,M.E.; Afodun, A.M.; Ayinla, M.T.; Raji, A.O.; Liadi, M.T.; Belewu, M.A.
    Caffeine is one of the most frequently ingested pharmacological agents contained in several beverages and food items. With some positive biological effects on the body system, little knowledge is known on its effect on reproductive parameters. This present study therefore aimed to determine the effect of aqueous solution of caffeine on serum testosterone level and body mass index (BMI) in male Wistar rats. Twenty-one (21) male Wistar rats with average weight of 250 ± 20 g were obtained for this study and randomly grouped into three (3) of seven (7) rats each. Group A, served as the control and received 0.5 ml of normal saline while groups B and C served as test groups and received orally 0.38 mg/kg (low dose) and 1.14 mg/kg (high dose) of caffeine respectively, once daily for 14 days. There was significant increase (p<0.05) in body weight, BMI, and plasma testosterone levels of high dose (HD) and low dose (LD) compared to the control, while there was no significant (p>0.05) change in length of the animals compared to the control. Long time consumption of caffeine has potential to stimulate production of testosterone to possibly increase sex drive perhaps via hypothalamo-pituitary-testicular axis, and also increase BMI.