Browsing by Author "Ayinde Olarewaju Toafeek"

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    Favourable pregnancy outcome following gliclazide use throughout pregnancy in diabetic female Sprague-Dawley rats
    (Lagos State University College of Medicine, 2018) Ojulari Lekan Sheriff; Kadir Risikat Eniola; Abdulazeez Fatima I.; Ayinde Olarewaju Toafeek; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adegoke Olufeyisipe A.
    Objectives: The incidence of diabetes mellitus (DM) is associated with complications with reproduction. The effect of gliclazide on pregnancy hormones and fetal outcomes in diabetic female rats was determined in this study. Methods: There were four experimental groups (control, diabetic control, gliclazide-treated and diabetictreated) of 20 rats each. Studies were carried out on days 7, 14, 19 and at term, to ascertain implantation, gestation, fetal outcome and measurement of some plasma hormone levels. Values represent mean ± SD and were analyzed by two-tailed ANOVA followed by a Post-hoc test. Differences were considered significant at p<0.05. Results: There were increases inplasma estradiol in the gliclazide-treated non-diabetic [day 14 (55.80±1.0; p=0.01), day 19 (55.80±3.1;p=0.02)] and diabetic [day 14 (25.42±1.7); p=0.03] groups, and also in plasma progesterone in the treated diabetic group [day 14 (35.12±6.2) p=0.02] only. Plasma corticosterone and plasma CRP decreased in the gliclazide-treated [corticosterone day 14 (356.30±24.1) p=0.01; day 19 (308.30±17.6) p=0.01]; [CRP day 14 (0.13±0.05) p=0.01] and the diabetic-treated [corticosterone day 14 (400.50±21.5) p=0.01, day 19 (424.10±22.4) p=0.01; [CRP day 14 (0.14±0.13) p=0.01] groups. There were no significant changes in the plasma levels of β-hCG and no abnormalities were observed in litters from all groups. Conclusion: Gliclazide improved some reproductive complications in the diabetic state and in the nondiabetic state. Consideration should be given to its use in managing reproductive complications associated with DM.