Browsing by Author "Ayinde, Taofeek Olanrewaju"

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    Comparative analysis of handgrip strength and urine C-peptide creatinine ratio as biomarkers for glucose regulation in young adult females in the University of Ilorin: A cross-sectional study.
    (Nigerian Society for Experimental Biology., 2023) Ojulari, L.ekan Sheriff; Sulaiman, Swabirah E.; Ayinde, Taofeek Olanrewaju; Kadir, Eniola Riskat; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Sulaiman, H.
    Handgrip strength (HGS) is a robust biomarker predicting future disability, metabolic syndrome, and diabetes. Urinary C-peptide creatinine ratio (UCPCR) emerges as a novel, non-invasive tool under exploration for assessing beta cell function and glucose regulation. Despite their significance in gauging muscle strength, mass, and overall metabolic function, gaps remain in understanding the full extent of handgrip strength and UCPCR's efficiency. This study aimed to identify a better biomarker for glucose regulation by studying the relationship between handgrip strength, urine c-peptide creatinine ratio, and blood glucose levels in adult females. Using ELISA, the study measured handgrip strength, blood glucose levels, and urine samples. Social demographic data was obtained through standard questionnaires, and statistical analysis was done using IBM 25 SPSS software with Pearson's correlation, linear regression at P=< 0.05, and T-test. The study found that handgrip strength (HGS) had a slight non-significant positive correlation with fasting blood sugar (FBS) (P=0.386). However, there was a significant correlation between HGS and 2 hours postprandial glucose (2HPG) in both dominant and non-dominant hands (P= 0.045 vs P= 0.017). Additionally, the study found that handgrip strength in the dominant hand was significantly stronger than that in the non-dominant hand (P= 0.001). On the other hand, the urinary C-peptide creatinine ratio (UCPCR) had no significant correlations with FBS and 2HPG. Handgrip strength measurements provide an indicative approach for glucose regulation and are a better biomarker for blood glucose regulation than UCPCR
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    Effects of Melatonin and Ethanolic Extract of Cannabis Sativa leaves on Sexual Behaviour Parameters of Female Wistar Rats
    (Nigerian society for experimental biology, 2020) Oluwasola, Amuda; Olayaki, Lukmon Aribidesi; Ayinde, Taofeek Olanrewaju
    : Cannabis is the most commonly abused illicit drugs with medicinal values worldwide. However, there have neither been studies to explain the contribution of oxidative stress on cannabis-related female gonadotoxicity nor the possible ameliorative potential of melatonin on gonadotoxicity in females consuming cannabis. This study investigated the ameliorative property of melatonin on gonadotoxic effects of cannabis sativa in female rats. Twenty female rats (156g ± 1.05) and four male rats (192g ± 1.42) were assigned into four groups of six animals each (female to male ratio, 5:1), such that the rats in groups I, II, III and IV received orally 1mL of distilled water, 2mg/kg of ethanolic extract of cannabis sativa (EECS), 2mg/kg of EECS plus 4mg/kg of melatonin and 4mg/kg of melatonin, respectively. The female sexual behaviour parameters were monitored on days 7 and 14 respectively. Gonadotropin releasing hormone, Luteinizing hormone, follicle stimulating hormone, estradiol, progesterone and prolactin were determined. EECS significantly (p<0.05) reduced darting frequency, hopping frequency, lordosis frequency, licking behavior, GnRH, FSH, LH, estradiol, progesterone and prolactin respectively. However, it increased the darting latency, hopping latency and lordosis latency significantly (p<0.05). All these effects were significantly reduced (p<0.05) when combined with melatonin. The study revealed that EECS decreased sexual behaviour parameters which was ameliorated by melatonin.