Browsing by Author "Attah, F.A.U."

Now showing 1 - 3 of 3
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    Effects of UV, Red and Sun Light on the Stability of Phytochemicals, Antioxidant and Antimicrobial Activity in the Rhizomes of Zingiber Officinale(Zingiberacea)
    (Pharmaceutical Society of Kenya, 2020) Njinga, N.S.; Bakare-Odunola, M.T.; Abdullahi, S.T.; Abdulmajeed, F.F.; Bello, H.R.; Adediran, J.O.; Muhammad, Z.T.; Egharevba, G.O.; Shittu, A.O.; Attah, F.A.U.
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    Extractive Values and Diuretic Activity of Methanol Extract of Three Varieties of Hibiscus sabdariffa Linn (Malvaceae) in Wistar Albino Rats
    (Published by the Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, 2018) Usman, S.O.; Ayanniyi, R.O.; Abdullahi, A.A.; Musa, M.; Lawal, B.A.; Salawu, M.K.; Attah, F.A.U.
    Hibiscus sabdariffa Linn (Malvaceae) is widely cultivated in Nigeria as food and for medicinal purposes. The calyx is the most frequently used part of the plant and has been reported to have antioxidant, antihypertensive and diuretic activity. The aim of the present study is to determine the extractive values and diuretic activity of three varieties of H. sabdariffa. Aqueous, methanol, ethanol, chloroform and hexane soluble extractive values were determined. The effect of the extracts of H. sabdariffa on urine output was evaluated and the concentration of sodium and potassium in blood was also determined. The results showed that water extract had the highest extractive value (32.90%, 26.50% and 29.00%) for the three varieties (Dark red, Light red and Green) respectively. H. sabdariffa extract (100 mg/kg G) produced a significant (p<0.05) increase in urine output compared to the control. The diuretic activity of extract was comparable with the standard drug Hydrochlorothiazide (10 mg/kg). The other species of H. sabdariffa extract produced no significant increase in urine output. H. sabdariffa extract (200 mg/kg G) showed a significant (p<0.05) natriuretic activity compared to control. There was no significance difference in the serum potassium levels for all the three varieties at the doses employed. The study showed that water is the most suitable solvent for extraction of the calyx of H. sabdariffa and the green variety produced a significant increase in urine output with potassium sparing activity. _____________________________________________________________________
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    Phytochemical, antioxidant and antimicrobial studies of partitioned fractions of Lannea kerstingii Engl. And K. Krause (Anarcadiaceae)
    (West African College of Postgraduate Pharmacists, 2021) Njinga, N.S.; David, S.M.; Shittu A.O.; Lawal, B.A.; Bello, R.H.; Attah, F.A.U.; Usman, S.O.; Abdullahi, A.A.; Bakare-Odunola, M.T.
    Background: Antimicrobial resistance is a serious threat to global public health and requires actions like the development of new antimicrobial with significant activities over existing drugs. Objectives: This study aims at investigating the phytochemical, antioxidant and antimicrobial potentials of partitioned fractions of Lannea kerstingii. Methods: A quantitative phytochemistry of chloroform, ethyl acetate, acetone and methanol fractions of L. kerstingii for total flavonoid, phenol and alkaloid were done using standard method; antioxidant and antimicrobial activity were determined using 1,1-Diphenyl-2-picrylhydrazyl and agar diffusion method respectively. Results: The chloroform fraction contained only alkaloid (11%) and steroids while all the other fractions contained phenolic compounds in the range 0.43 to 0.67 mg/g garlic acid. The total flavonoid content ranged from 0.43 to 0.67 mg/g of quercetin. The total flavonoid in the ethyl acetate was significantly different from that of the methanol fraction but not with the acetone fraction. The acetone fraction showed highest antioxidant activity (60.4%) at 0.05 mg/mL though not as comparable to vitamin C. The ethyl acetate showed high antimicrobial activity as it was active against most of the organisms tested upon and zone of inhibition ranged from 13±0.02 to 29±0.1 mm. The acetone fraction was active only against T. mentagrophytes while the methanol fraction showed no activity. Conclusion: The antioxidant and antimicrobial activities may be due to the presence of flavonoids, as well to the presence of tannins and terpenoids present in the different fractions. This makes the ethyl acetate fraction a good source of antioxidant and antimicrobial agent.