Browsing by Author "Ananias, E. N."

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    Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
    (Biomedical Communications Group, Ibadan, Nigeria, 2022-10) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Akintoye, O. O.; Ajibare, A. J.; Jimoh, O. S.; Owoyemi, J. O.; Ananias, E. N.; Ibiyeye, V. O.; Aboyeji, A. M.; Ojulari, L. S.
    Aqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (p˂0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
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    Ficus exasperata leaves aqueous extract influences pathophysiologic mechanisms of diabetic peripheral neuropathy in a rat model.
    (Open Science Publishers LLP, 2023-09-04) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ajibare, A. J.; Akintoye, O. O.; Jimoh, O. S.; Ananias, E. N.; Owoyemi, J. O.; Ibiyeye, V. O.; Ojulari, L. S.
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    Haemoglobin has no influence on pain perception of undergraduate students in Ilorin, North-Central, Nigeria
    (African Science Publications, 2024-10-21) Jimoh-Abdulghaffaar, H. O.; Olaniyan, O. E.; Jimoh, O. S.; Ananias, E. N.; Owoyele, B. V.
    Pain perception is influenced by various factors, including genetics, awareness, age, gender, and environmental factors (Hussain and Karim, 2019). This study aimed to determine if hemoglobin genotype variability affects human perception of pain. 208 participants aged 17-45 years from the University of Ilorin were recruited using purposive sampling. The participants were counselled and verbal consent was gotten from them before the procedure. Pain threshold and tolerance were assessed using the cold pressor test. 5mls of blood was drawn from antecubital vein and stored in Ethylenediamine tetraacetic acid (EDTA) bottles at 2⁰-6⁰C until hemoglobin electrophoresis was carried out. Data were analyzed using SPSS version 28.0 and presented as mean ± SD, median IQR, frequency as well as percentages and p-value < 0.05 was considered statistically significant. Sociodemographic results showed that 2.4% of participants were older than 35 years, 97.6% are unmarried and 85.6% are Yoruba. Hemoglobin electrophoresis revealed that 64% of participants were HbAA, 28.8% HbAS, 4.8% HbSS, and 2.4% HbAC. No significant variation was found in pain threshold between genotypes, though participants with the HbAS genotype had the highest pain threshold and the lowest pain tolerance, this warrants further investigation in larger sample. Higher pain threshold and tolerance may be conferred by HbS and HbC characteristics.