Browsing by Author "Amuda, O.,"

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    Effect of garcina kola seed on plasma C-reactive protein in human subjects
    (The Nigerian Journal of Pure & Applied Sciences,, 2013) Owoyele, B. V.,; Oyewole, A.L.; Amuda, O.,; Abioye, A.; Biliaminu, S. A.
    Garcinia kola seed ( Garcinia afzelii; also called bitter kola seed) i s a common .Africa snack fruit from a species of flowering plant in the Guttiferae family. Over the years, Africa traditional medicine and ethino pharmacology have attached invaluable roles to Garcinia kola seed (GKS) as a potent anti­hepatotoxic, anti-diabetic. antioxidant and antilisterial. To consolidate these roles. we focus our study on the effect of GKS on C-reactive protein (CRP) in human subjects. Sixty students voluntccrs (n=60 30 female & 30 male) from Faculty of Basic Medical Sciences. U nivcrsl ty of I lorin. N igeria. were used for this study. The screened voluntccrs were subjected to an hour rest for acclitnatization. This was follow by collection of about 2.5 ml of blood through venc puncture. The subjects were then asked to ingest 100 mg/k g of GKS and after 6 hours, another 2.5 ml of blood sample was collected from each subject. The level of C'RP was assay in the two sets of blood samples. The result shows 66.31%, significant decrease in the mean level of basal CRP of the female (p< 0.05). Contrast to this, inmale, there is 72.2 7% signi ficant increase from the mean level of basal CRP (p < 0.05). In conclusion. this study shows GKS as a potent anti-in flammatory fruit for female suhjects but not for male subjects. GKS anti-inflammatory effects are thus gender based. With these observations. it can be said to be more beneficial to female but not to male subjects . Lastly. the clinical practse or using CRP level in the blood to predict the pathogenesis of a disease, track of a disease progress or measure of effcct iveness of a treatment will be mislcading in habitual GKS consuming pati ents.