Browsing by Author "Amin, Abdulbasit"

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    Hippocampal-dependent spatial memory and histoarchitectural integrities of the ca regions of wistar rats following administration of rauwolfia vomitoria and chlorpromazine
    (Neuroscience Society of Nigeria, 2015) Ajao, Moyosore Saliu; Imam, Aminu; Ajibola, Musa Iyiola; Abdulmumin, Ibrahim; Amin, Abdulbasit; Adana, Misturah Yetunde; Olawepo, Ayokunle; Abdulmajeed, Wahab Imam
    Psychotic patients demonstrate poor spatial memory, ascribed to impaired hippocampal functions, and bodies of evidences have attributed cognitive impairments to the poor functional outcomes in psychosis management. The efficacy of chlorpromazine and Rauwolfia vomitoria on spatial memory performance and differential histoarchitecture of the hippocampi of adult Wistar rats was examined in this study. Twenty five adult male Wistar rats weighing between 200 - 230 g were randomly grouped to five (Normal, low and high dose chlorpromazine and low and high dose R. vomitoria) of five animals each. 2 ml of normal saline was given to Control animals daily, 5mg/kg of chlorpromazine was given as low dose, 10 mg/kg of chlorpromazine was given as moderate dose, 150 mg/kg of R. vomitoria was given as low dose and 300 mg/kg of R. vomitoria was given as high dose orally. All the medications were given daily for 21 days. A Y-maze apparatus was used to assess the spatial memory performance in the rats at days 14 and 21 of the experiment. All the animals were euthanized using 20 mg/kg of intramuscular ketamine, cardially perfused with 4% paraformaldehyde, the brains and the hippocampus removed for histological analysis. Results from this study show that Rauwolfia at 150 and 300 mg/kg improved the correct decision (right triplet alternation) and reduced wrong decision (wrong triplet alternation) in the treated rats at days 14 and 21 respectively with an unaltered hippocampal histoarchitecture. While chlorpromazine at 5 and 10 mg/kg induced an increased wrong decision (wrong triplet alternation) and reduced correct decision (right triplet alternation) across treatment periods and caused an apparent distortion in the hippocampus. In conclusion, R. vomitoria could be a better alternative agent with more therapeutic potential in the treatment of psychosis and could possibly remediate cognitive impairments in psychosis.
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    Oral Ingestion of Cannabis sativa: Risks, Benefits, and Effects on Malaria-Infected Hosts
    (Cannabis and Cannabinoid Research, 2018-11-22) Akinola, Olugbenga; Ogbeche, O.Elizabeth; Olumoh-Abdul, H.A; Alli-Oluwafuyi, O. Abdulmusawwir; Oyewole, L. Aboyeji; Amin, Abdulbasit; AbdulMajeed, I. Wahab; Olajide, J. Olayemi; Nafiu, B. Abdurrazaq; Njan, A. Anoka; Olorundare, E. Olufunke; Gbotosho, O. Grace
    Background: The emergence of a multidrug-resistant strain of Plasmodium falciparum (Pf Pailin) raises concern about malaria control strategies. Unfortunately, the role(s) of natural plants/remedies in curtailing malaria catas￾trophe remains uncertain. The claims of potential antimalarial activity of Cannabis sativa in vivo have not been well established nor the consequences defined. This study was, therefore, designed to evaluate the effects of whole cannabis consumption on malaria-infected host. Methods: Thirty mice were inoculated with dose of 1 · 107 chloroquine-resistant Plasmodium berghei ANKA￾infected erythrocyte and divided into six treatment groups. Cannabis diet formulations were prepared based on weighted percentages of dried cannabis and standard mice diet and the study animals were fed ad libitum. Chemosuppression of parasitemia, survival rates, parasite clearance, and recrudescence time were evaluated. His￾topathological studies were performed on the prefrontal cortex (PFC) and hippocampus of the animals after 14 days’ consumption of cannabis diet formulation by naive mice. Results: There was a significant difference ( p < 0.05) in the day-4 chemosuppression of parasitemia between the animals that were fed C. sativa and chloroquine relative to the untreated controls. There was also a significant difference in the survival rate ( p < 0.05) of animals fed C. sativa diet (40%, 20%, 10%, and 1%) in contrast to control animals on standard mice diet. A parasite clearance time of 2.18 – 0.4 was recorded in the chloroquine treatment group, whereas recrudescence in chloroquine group occurred on day 7. There were slight histomorphological changes in the PFC and cell densities of the dentate gyrus of the hippocampus of animals that were fed C. sativa. Conclusions: C. sativa displayed mild antimalarial activity in vivo. There was evident reduction in symptomatic man￾ifestation of malaria disease, though unrelated to levels of parasitemia. This disease tolerance status may be beneficial, but may also constitute a transmission burden through asymptomatic carriage of parasites by habitual cannabis users.