Browsing by Author "Alabi A.S."
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Item Alterations in the levels of female sex hormones following administration of nicotine to Wistar rats(Library and Publications Committee, University of Ilorin, 2019) Omotoso G.O.; Kadir R.E.; Alabi A.S.; Olayaki L.A.; Femi-Akinlosotu O.The indiscriminate use of nicotine is a serious public health challenge worldwide. In this work, the effect of nicotine was studied on female sex hormones using adult female Wistar rats. Fifteen (15) animals were grouped into three equally as, Group A (Control, given 0.1 ml of normal saline), Group B (given 0.03 mg/kg nicotine), and Group C (received 0.06 mg/kg nicotine). All administration was via the intraperitoneal route, once daily for five (5) consecutive days. All the animals were sacrificed by cervical dislocation about 24 hours after the last treatment, and intracardial blood samples obtained. Using appropriate biochemical kits, the serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, oestrogen and progesterone were determined. The results showed a dose-dependent significant increase in serum levels of the gonadotropins and progesterone, and a marked increase in serum levels of oestrogen and prolactin in animals treated with low dose nicotine, but significantly low levels of these hormones were recorded in animals treated with higher dose of nicotine. Administration of nicotine affects the female sex hormones adversely, and this by extension could affect female reproductive activities.Item Central Cholinergic Markers and Spatial memory Performance in rats following administration of Rauwolfia Vomitoria and Chlorpromazine(Centre Point Journal (Science Edition). Published by Library and Publication Committee, University of Ilorin, 2015) Ajao M.S.; Imam A.; Adana M.Y.; Kareem S.B.; Alabi A.S.; Olawepo A.; Okesina A.; Kadir R.E.; Oyewopo A.O.The study was designed to compare the effects of Rauwolfia vomitoria and chlorpromazine on metabolic activities, spatial memory performance, central cholinergic markers, oxidative stress markers and neurohistoarchitecture in the brain of adult wistar rats. Twenty five adult male wister rats weighing between 200 - 230 g were divided into five groups (A-E) of five rats each. Group A (control) received 2mls of normal saline daily, Group B received 5mg/kg of chlorpromazine, Group C received 10 mg/kg of chlorpromazine, Group D received 150 mg/kg of R. vomitoria and Group E received 300 mg/kg of R. vomitoria orally. All the medications were given daily for 21 days. Body weights were taken weekly and recorded. A y-maze apparatus was used to assess the spatial memory performance in the rats at days 14 and 21 of the experiment. All the animals were euthanized using 20mg/kgbw of intramuscular ketamine, cardially perfused with 4% paraformaldehyde and the brains were removed, some were homogenised for analysis of central cholinergic markers and others for histological analysis. Low doses of chlorpromazine increase body weight and Rauwolfia vomitoria increase central cholinergic markers. The findings of the study show that R.vomitoria and chlorpromazine exert differential and dosage dependent effects on body weight, central cholinergic neurons and learning performance. The conclusion from the study indicates that R. vomitoria could be a better alternative drug in the treatment of psychosis with lesser metabolic and central nervous system side effects.Item Central cholinergic markers and spatial performance in rats following administration of rauwolfia vomitoria and chlorpromazine(Center Point Journal (Science Edition). The Official Journal of the Library and Publications Committee, University of Ilorin, Ilorin., 2015) Ajao M.S.; Imam A.; Adana M.Y.; Kareem S.B.; Alabi A.S.; Olawepo A.; Okesina A.A.; Kadir R.E.; Oyewopo A.O.The study was designed to compare the effects of Rauwolfia vomitoria and chlorpromazine on metabolic activities, spatial memory performance, central cholinergic markers, oxidative stress markers and neurohistoarchitecture in the brain of adult wistar rats. Twenty five adult male wister rats weighing between 200 - 230 g were divided into five groups (A-E) of five rats each. Group A (control) received 2mls of normal saline daily, Group B received 5mg/kg of chlorpromazine, Group C received 10 mg/kg of chlorpromazine, Group D received 150 mg/kg of R. vomitoria and Group E received 300 mg/kg of R. vomitoria orally. All the medications were given daily for 21 days. Body weights were taken weekly and recorded. A y-maze apparatus was used to assess the spatial memory performance in the rats at days 14 and 21 of the experiment. All the animals were euthanized using 20mg/kgbw of intramuscular ketamine, cardially perfused with 4% paraformaldehyde and the brains were removed, some were homogenised for analysis of central cholinergic markers and others for histological analysis. Low doses of chlorpromazine increase body weight and Rauwolfia vomitoria increase central cholinergic markers. The findings of the study show that R.vomitoria and chlorpromazine exert differential and dosage dependent effects on body weight, central cholinergic neurons and learning performance. The conclusion from the study indicates that R. vomitoria could be a better alternative drug in the treatment of psychosis with lesser metabolic and central nervous system side effects.Item DETERMINATION OF SEX FROM OCCIPITOFRONTAL CIRCUMFERENCE, BIRTH WEIGHT AND PLACENTA WEIGHT OF NEONATES IN SELECTED PRIVATE HOSPITALS IN ILORIN METROPOLIS IN NIGERIA(KJHS, 2023) Alabi A.S.; Abioye O.D; Salako A.O; Adumo G.O.; Babatunde E.O.; Amasiatu V.C.; Aigbogun Jr. E.O; Usman I.M.The aim of the study is to determine the sex of neonates from the occipitofrontal circumference, weight of neonate, and weight of placenta in selected private hospitals in the Ilorin metropolis. The sample study comprised 244 subjects (122 males and 122 females) having no birth deformities. The occipitofrontal circumference was taken using an infant head circumference tape. The weight of birth and the weight of the placenta was measured using an analogue baby weighing scale. Pearson’s Chi square and Chi-square Automatic Interaction Detector (CHAID) decision tree analysis were used to analyze the data. 𝑃 < 0.05 was considered significant. The result showed that birth weight, placental weight and occipitofrontal circumference did not determine the sex of neonates. There were no significant relationships between each of the neonatal parameters and the sex of neonates. An increase in the birth weight led a significant increase in the placental weight. Also, the placental weight was significantly different in terms of the mode of delivery; it being higher in neonates born via C/S. Keywords: Neonates, Placental weight, Birth weight, Occipitofrontal circumferenceItem Reproductive System and Perineum(Department of Anatomy, University of Ilorin., 2024) Kadir E.R.; Oyewopo A.O.; Alabi A.S.