Browsing by Author "Alabi, AS"
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Item Beneficial effects of low dose Musa paradisiaca on the semen quality of male Wistar rats.(Nigerian Medical Journal, 2013) Alabi, AS; Omotoso, Gabriel Olaiya; Enaibe, BU; Akinola, OB; Tagoe, CNBBackground: This study aimed at determining the effects of administration of mature green fruits of Musa paradisiaca on the semen quality of adult male Wistar rats. Materials and Methods: The animals used for the study were grouped into three: the control group, given 2 ml of double distilled water, a low dose group given 500 mg/kg/day and a high dose group given 1000 mg/kg/day of the plantain fruits, which was made into flour, and dissolved in 2 ml of double distilled water for easy oral administration. Results: Significant increment in the semen parameters was noticed in animals that received a lower dose of the plantain flour, but those animals who received the high dose had marked and very significant reduction in sperm cell concentration and percentage of morphologically normal spermatozoa. Conclusion: Musa paradisiaca should be consumed in moderate quantities in order to derive its beneficial effects of enhancing male reproductive functions.Item Central cholinergic markers and spartial memory performance in rats following administration of Rauwolfia vomitoria and chlorphromazine(Library and Publications Committee University of Ilorin, Ilorin, Nigeria, 2015) Ajao, MS; Imam, A; Adana, MY; kareem, SB; Alabi, AS; Olawepo, A; Okesina, AA; Kadri, RE; Oyewopo, AOItem Cytotoxic potentials of thiocyanate administration on the liver of male Wistar rats (Rattus norvegicus)(Anatomy Journal of Africa,, 2016) Alabi, AS; Nurudeen, MN; Omotoso, Gabriel Olaiya; Oyewopo, AO; Olawepo, A; Ajao, MSThe use of thiocyanate as an anti-sickling drug is currently on the increase among sickle cell disease (SCD) patients. The continuous use of this substance without sufficient toxicity data does not guaranty continuously functional and healthy internal organs among the SCD patients that are susceptible to multi-organ failure such as hepatic failure. Hence this study was performed to elucidate the consequence(s)of thiocyanate administration on the liver of adult male wistar rats. Twenty adult male wistar rats with an average weight of 234.5g were used. The rats were grouped into four (A, B, C & D) with five animals in each group. Group A represented the control and was given only 1ml of distilled water daily while B,C,&D received 1ml of thiocyanate solution at doses of 10mg/Kg/day, 20mg/Kg/day, & 30mg/Kg/day for twenty-eight (28) days. The administration was carefully done with the use of an oral cannula. Thereafter, the rats were sacrificed via cervical dislocation. The rats were dissected and blood samples were immediately collected from the apex of the heart for the analysis of serum total bilirubin. A fraction of the liver was cut to prepare homogenates for biochemical enzymes (alanine aminotransferase-ALT, aspartate aminotransferase-AST) analysis. Thereafter the animals were wholly perfused with normal saline and then fixed with 4% paraformaldehyde. The fixed liver tissues were then taken for histological assessments. The slide sections (H&E and PAS stains) in the treated groups showed varying degrees (mild to severe disruption of hepatocellular morphology plus prominence and widening of sinusoids) of thiocyanate-induced liver damage. But hepatocellular appearance was normal in the control group. Biochemical assays of serum total bilirubin and tissue AST increased fairly with increasing dose although this was not significant. The increase in tissue level of ALT in group B was also not significant with respect to the control. But increase in ALT level was found to be significant in groups C&D when compared with the control. Therefore, this study can be used to infer that SCN use in sickle cell disease management regimen can cause hepatocellular damage in wistar rats.Item Developmental changes in frontocortical morphology and neurochemistry of neonatal rats following gestational nicotine exposure.(Anatomy Journal of Africa,, 2017) Omotoso, Gabriel Olaiya; Alabi, AS; Akinola, OB; Enaibe, BUExposure of the embryo or foetus to nicotine during development results in some forms of neurological deficits later in life. The current study aimed at determining the effects of prenatal nicotine administration during the 1st and 2nd gestational weeks on the frontal cortex of neonatal Wistar rats. For each week of gestation, pregnant Wistar rats were assigned to 3 groups: a control group (1), and two treated groups (2 and 3), and were given intra-peritoneal nicotine at 6.88 mg/ kg and 13.76 mg/kg doses respectively. The weights of the litters were taken at birth and at postnatal day 4; the whole brain and frontal cortical weights were also assessed. Tissues for histological demonstration were fixed in freshly prepared formol calcium, while specimen for biochemical studies were homogenised and processed for the determination of alkaline phosphatase (ALP) and malondialdehyde (MDA) activities. Findings in the treated animals showed low birth weights, raised ALP but reduced MDA, with corresponding alterations in the cortical cytoarchitecture, which could explain some of the pathological basis for the neurobehavioural problems associated with offspring of women smokers.Item Effects of albendazole administration on the testicular histology of adult Wistar rats.(Journal of Experimental and Clinical Anatomy, 2013) Omotoso, Gabriel Olaiya; Alabi, AS; Oyabambi, AOBackground: The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains. Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males.Item Gestational nicotine exposure alters oligodendrocyte morphology and axonal myelination in the lateral prefrontal cortex of young Wistar rats.(Nigerian Journal of Neuroscience,, 2015) Omotoso, Gabriel Olaiya; Alabi, AS; Femi-Akinlosotu, Omowumi; Akinola, OB; Enaibe, BU; Caxton-Martins, Ezekiel AdemolaPrenatal exposure of the foetus to chemical insults has implications on the overall growth and development of the baby before and after birth. This study examined the effects of prenatal exposure to nicotine on the morphology of oligodendrocytes which are responsible for the development of myelin in the central nervous system, and are critical in neurodevelopment. Twenty adult female Wistar rats were used for the study. Their oestrous cycle was determined by vaginal smearing, and subsequently exposed to male rats for mating. The female Wistar rats were thereafter grouped into two and each group was further subdivided into a saline-treated control and a nicotine-treated subgroup. Each treatment lasted 5 consecutive days between days 9-13 (Group A) and days 16-20 (Group B) of pregnancy. The pups were allowed to grow and, at postnatal day 15, were euthanized and perfusion-fixed transcardially. The lateral prefrontal cortex was processed for histochemical, immunohistochemical and electron microscopic studies. Findings indicated marked decrease in oligodendrocyte count, reduced expression of myelin basic protein (MBP), and impaired myelin formation. These changes can affect the normal growth and development of the brain with severe implications on cognitive and motor functions after birth.Item Lawsonia inermis leaf extract mitigates aluminium-induced testicular toxicity in wistar rats: Immunohistochemical study(Centre for Malaria Research & Phytomedicine, University of Port-Harcourt, 2018) Olawuyi, TS; Oladipo, GS; Alabi, AS; Oyewopo, AO; Omotoso, GOItem Lip Print Morphological Pattern in Relation to Nasal Index Among Adults of Egba, in Abeokuta, South-West Nigeria(Enugu State university of Science and technology, 2021-06) Alabi, AS; Omoge, OE; Kareem, SB; Imam-Fulani, AOItem Morphological pattern of lip print among adults of Ijesha Ethnic group, Osun State, Nigeria(Anatomical society of Nigeria, 2021) Alabi, AS; Abikan, LA; Kareem, SB; Odunnaike, OO; Adigun, FM; Imam-Fulani, AO; Abdulraheem, AMCheiloscopy is an investigational technique under forensic science that deals with study of uniqueness of lip prints among individuals. The aim of this work is to study the lip print patterns of Ijesa people in Osun state, Nigeria. The study group comprises of 205 males and 205 females within the age group of 18-65 years. The subjects were asked to clean their lips with the baby wipe and little quantity of lip gloss applied evenly on the sulci laborium of the upper and lower lips. The subjects were then made to stand/sit in a relaxed position and asked to keep the lip muscles relaxed and the jaw kept closed while the prints were being taken. A clear new microscopic glass slide was placed on the relaxed lips of the subject in a single motion tilting it slightly to the right and left. The lips were divided into six compartments and classified according to Suzuki and Tsuchuchashi's classification. Data were analyzed using SPSS version 20.0 software package. Chi-square Automatic Interaction Detective (CHAID) was used to analyze and compare the lip print pattern and the analyses were presented in tables and variables in categorical forms, thus it was presented as frequency, p-value was set at ? 0.05 to be significant. The result of this study with respect to sex shows that type I was dominant in male while type III was dominant in female. The predominant lip print pattern among Ijesa ethnic group was type III. In conclusion, there is a sexual dimorphism in the lip print pattern in Ijesha ethnic group and this can be used in personality identification in forensic anthropology.Item Regression equations for stature prediction in Nigerian Hausas, Igbos and Yorubas from toe length and toe-length ratios.(School of Anthropology, San Francisco State University, USA, 2017) Alabi, AS; Oladipo, GS; Didia, Bc; Aigbogun, EO