Browsing by Author "Akinwumi, O.O."
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Item Changing pattern of haematological malignancies in Ilorin, Nigeria: A 10 year retrospective review of 181 cases(Ambrose Alli University, 2016) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Akinwumi, O.O.Abstract The global burden of cancer has been reported to be on the increase and haematological malignancies (HM) are not exceptions to this observed trend. The aim of this study was to carry out a retrospective analysis of all cases of HM seen at the University of Ilorin Teaching Hospital, Ilorin and document the current pattern of HM and compare with previous reports from Nigeria and elsewhere. Materials used for the study were obtained from the Records Cancer Registry of the University of Ilorin Teaching Hospital. A total of 181 cases of HM were diagnosed and managed within the study period constituting 8.1% of all cancer cases and 0.2% of all hospital admissions. The ages of patients with HM ranged from 7 months to 80 years. There were 116 (64.1%) males and 65 (35.9%) females. The various HM recorded in the study were: ALL 17(9.4%), AML 23(12.7%), CLL 33(18.2%), CML 46(25.4%), NHL 33(18.2%), HL 7(3.9%), BL 2(1.1%) and MM 20(11.0%). CML was the commonest HM observed in this study. NHL was the commonest lymphoma encountered constituting 82.5% of all the lymphoma cases. This study demonstrated that haematological malignancies are common in this environment. Availability of improved diagnostic facilities, improved blood transfusion services, early presentation and better referral system from other health facilities to our centre may have contributed to the improved mean survival of patients with HM observed in this study.Item Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria(Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.