Browsing by Author "Akinlolu, AA"

Now showing 1 - 3 of 3
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    Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis.
    (Anatomy and Cell Biology,, 2018) Omotoso, Gabriel Olaiya; Gbadamosi, IT; Afolabi, TT; Abdulwahab, AB; Akinlolu, AA
    Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis. Moringa oleifera is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability of M. oleifera in cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone, M. oleifera and a combination of M. oleifera and cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration of M. oleifera significantly reversed the neuropathological deficits induced by cuprizone.
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    Identification of the anthropometric index that best correlates with fasting blood glucose and BMI in post-pubescent female Nigerians.
    (Anatomy Journal of Africa,, 2014) Akinola, OB; Omotoso, Gabriel Olaiya; Akinlolu, AA; Ayangbemi, KD
    The association between anthropometric indices and the incidence of metabolic disturbances varies between age groups and races. In this study, we report the relationship between fasting blood glucose (FBG) and some anthropometric markers of body mass and central obesity in a population of postpubescent female Nigerians (16-23 years). After obtaining written consent from each of the 178 subjects; and the completion of a questionnaire on individual demographics, we collected the following anthropometric data: waist circumference (WC), hip circumference (HC), height (H), and weight (W). We also estimated the body mass index (BMI), waist to hip ratio (WHR), and waist to height ratio (WHtR). Fasting blood glucose (FBG) was estimated using a glucometer. The mean FBG was 83.65 mg/dl and this was best positively and significantly correlated with BMI (r=0.15; P<0.05) in this population. Besides, among other obesity markers, WHtR was most strongly and significantly correlated with BMI (r=0.70; P<0.05). Our data shows that in young (post-pubescent) female Nigerians, the best anthropometric indicator of FBG (and thus of metabolic status), is the BMI, and this is most strongly correlated with WHtR in this particular population.
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    Moringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats.
    (International Journal of Morphology,, 2014) Akinlolu, AA; Ghazal, OK; Ameen, OM; Oyebanji, SC; Omotoso, Gabriel Olaiya
    SUMMARY: We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­ IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II ­ IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II ­ IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.