Browsing by Author "Akanbi, O.B."

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    Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats.
    (Elsevier Group, Netherlands, 2021) Ojuade, F.I.; Olorundare, O.E.; Akanbi, O.B.; Afolabi, S.O.; Njan, A.A.
    Background Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. Methods Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. Results Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. Conclusions This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats.
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    Reproductive pathology of experimentally induced lead poisoning in Red Sokoto Buck: Protective effect of tiger nut (Cyperus esculentus).
    (Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., 2020) Adam, M; Esievo, K.A.N.; Bisalla, M.; Ayo, J.O.; Aliyu, A.I.; Akanbi, O.B.; Baba, A.Y.; Raji L.O.; Salleh, A.
    Tiger-nut (Cyperus esculentus) is a crop that belongs to family Cyperaceae which produces rhizome and tuber that are small spherical in shape. The tubers have aphrodisiac, carminative, diuretics and several health benefits. The aim of the present study was to investigate the influence of methanol extract of tiger nut on the male reproductive pathology of chronic lead poisoning in Red Sokoto buck. The tiger nut was extracted using 95% methanol by cold extraction method. Four adults Red Sokoto bucks (12 to 25 kg) were randomly grouped into four. Group I was administered distilled water (200 mL). Group II was administered lead acetate (200 mg/kg) only. Group III was administered methanol extract of tiger nut (200 mg/kg) and lead acetate (200 mg/kg). Group IV was administered tiger nut (200 mg/kg) only. Evaluation of semen characteristics (semen motility, semen concentration, ejaculate volume and semen pH) were determined by standard method. The serum testosterone changes were determined using commercial kits. The lead acetate (200 mg/kg) group II showed decreased semen characteristics parameters while tiger-nut (LA + TN) group III showed improved values of the semen characteristics. However, the semen characteristics values on the distilled water (DW) group I and sole tiger nut (TN) group IV showed a good semen characteristics values. In conclusion the methanol extract of tiger nut contained antioxidant properties that significantly influence a protective role in ameliorating the pathological effect of lead poisoning in male reproductive pathology in Red Sokoto goat.