Browsing by Author "Ajibare, A. J."

Now showing 1 - 3 of 3
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    Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
    (Biomedical Communications Group, Ibadan, Nigeria, 2022-10) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Akintoye, O. O.; Ajibare, A. J.; Jimoh, O. S.; Owoyemi, J. O.; Ananias, E. N.; Ibiyeye, V. O.; Aboyeji, A. M.; Ojulari, L. S.
    Aqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (pĖ‚0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
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    Ficus exasperata leaves aqueous extract influences pathophysiologic mechanisms of diabetic peripheral neuropathy in a rat model.
    (Open Science Publishers LLP, 2023-09-04) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ajibare, A. J.; Akintoye, O. O.; Jimoh, O. S.; Ananias, E. N.; Owoyemi, J. O.; Ibiyeye, V. O.; Ojulari, L. S.
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    Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf2 up-regulation
    (Elsevier, 2022-10-20) Akintoye, O. O.; Ajibare, A. J.; Folawiyo, M. A.; Jimoh-Abdulghaffaar, H. O.; Asuku, A.; Owolabi, G. A.; Babalola, K. T.
    Sodium benzoate (SB) is a commonly-used food preservative, with a controversial report to its neurologicalbenefit and toxicity. Zinc (Zn) is a trace element that plays a crucial role in memory, inflammation and oxidativestress . This study was to investigate the effect of SB on rat cognition and memory and the possible modulatoryeffect of Zn supplement. Twenty four male Wistar rats were divided into four groups of six animals each. Animalsin groups 1ā€“4 were treated with normal saline 1 ml/kg, SB 200 mg/kg , zinc sulphate 10 ml/kg and SB 200 mg/kg+ zinc sulphate 10 ml/kg/day daily respectively for three weeks. After treatment, the animals were subjected todifferent behavioural tests, and then sacrificed. Their blood samples were collected for catalase(CAT), superoxidedismutase(SOD) and interleukin-1B(IL-1B) assay. Brain samples were also collected for nuclear factor-erythroid-related factor 2(Nrf2), and acetylcholinesterase (AchE) mRNA gene expression. The serum levels of CAT and SODwere (p < 0.0001; p < 0.0001) reduced in the SB only-treated group compared to the other groups. Nrf2 geneexpression was totally shut down in the SB only-treated group but, up-regulated in the Zn-treated groups(p < 0.0001). The serum level of IL-1B was higher in the SB only-treated group compared to the other groups. SB-treated group spent longer time in the close arm (p = <0.0001), shorter time in the open arm (p = <0.0001) andhad higher anxiety index (p = 0.0045) than the Zn-treated groups. Conclusively, Zinc improves memory deficit,has anxiolytic, anti-oxidant and anti-inflammatory properties.